Search Results - "Savulescu, Dana"

Nicotinamide pathways as the root cause of sepsis – an evolutionary perspective on macrophage energetic shifts by Suchard, Melinda S., Savulescu, Dana M.

“…Divergent pathways of macrophage metabolism occur during infection, notably switching between oxidative phosphorylation and aerobic glycolysis (Warburg‐like…”
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Evolutionary Views of Tuberculosis: Indoleamine 2,3-Dioxygenase Catalyzed Nicotinamide Synthesis Reflects Shifts in Macrophage Metabolism: Indoleamine 2,3-Dioxygenase Reflects Altered Macrophage Metabolism During Tuberculosis Pathogenesis by Suchard, Melinda S, Adu-Gyamfi, Clement G, Cumming, Bridgette M, Savulescu, Dana M

“…Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting enzyme in conversion of tryptophan to kynurenines, feeding de novo nicotinamide synthesis. IDO…”
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Indoleamine 2, 3-Dioxygenase-Mediated Tryptophan Catabolism: A Leading Star or Supporting Act in the Tuberculosis and HIV Pas-de-Deux? by Adu-Gyamfi, Clement Gascua, Savulescu, Dana, George, Jaya Anna, Suchard, Melinda Shelley

“…Progression from latency to active Tuberculosis (TB) disease is mediated by incompletely understood host immune factors. The definitive characteristic of…”
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HLA antibody repertoire in infants suggests selectivity in transplacental crossing by Savulescu, Dana M., Groome, Michelle, Malfeld, Susan C. K., Madhi, Shabir, Koen, Anthonet, Jones, Stephanie, Duxbury, Vania, Scheuermaier, Karine, De Assis Rosa, Debbie, Suchard, Melinda

“…Problem Late in pregnancy, women produce and transfer high amounts of antibodies to the foetus. During gestation, women produce antibodies against human…”
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Alloimmunity to Class 2 Human Leucocyte Antigens May Reduce HIV-1 Acquisition - A Nested Case-Control Study in HIV-1 Serodiscordant Couples by Suchard, Melinda S, Martinson, Neil, Malfeld, Susan, de Assis Rosa, Debbie, Mackelprang, Romel D, Lingappa, Jairam, Hou, Xuanlin, Rees, Helen, Delany-Moretlwe, Sinead, Goldfein, Hadassa, Ranchod, Heena, Coetzee, David, Otwombe, Kennedy, Morris, Lynn, Tiemessen, Caroline T, Savulescu, Dana M

“…Enveloped viruses, including the Human Immunodeficiency Virus-1 (HIV), incorporate host proteins such as human leucocyte antigens (HLA) into their envelope…”
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Diagnostic accuracy of plasma kynurenine/tryptophan ratio, measured by enzyme-linked immunosorbent assay, for pulmonary tuberculosis by Adu-Gyamfi, Clement Gascua, Snyman, Tracy, Makhathini, Lillian, Otwombe, Kennedy, Darboe, Fatoumatta, Penn-Nicholson, Adam, Fisher, Michelle, Savulescu, Dana, Hoffmann, Christopher, Chaisson, Richard, Martinson, Neil, Scriba, Thomas Jens, George, Jaya Anna, Suchard, Melinda Shelley

“…•Despite the availability of several TB diagnostics, there is an urgent need for a non-sputum-based test capable of detecting active TB.•Plasma…”
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Description of non-polio enteroviruses identified in two national surveillance programmes in South Africa by Howard, Wayne, Savulescu, Dana, Berrie, Leigh, Puren, Adrian J

“…Abstract only…”
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Plasma Kynurenine-to-Tryptophan Ratio, a Highly Sensitive Blood-Based Diagnostic Tool for Tuberculosis in Pregnant Women Living With Human Immunodeficiency Virus (HIV) by Adu-Gyamfi, Clement, Savulescu, Dana, Mikhathani, Lillian, Otwombe, Kennedy, Salazar-Austin, Nicole, Chaisson, Richard, Martinson, Neil, George, Jaya, Suchard, Melinda

“…For pregnant women living with human immunodeficiency virus (HIV), concurrent active tuberculosis (TB) disease increases the risk of maternal mortality and…”
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Evolutionary Views of Tuberculosis: Indoleamine 2,3‐Dioxygenase Catalyzed Nicotinamide Synthesis Reflects Shifts in Macrophage Metabolism by Suchard, Melinda S., Adu‐Gyamfi, Clement G., Cumming, Bridgette M., Savulescu, Dana M.

“…Indoleamine 2,3‐dioxygenase (IDO) is the rate‐limiting enzyme in conversion of tryptophan to kynurenines, feeding de novo nicotinamide synthesis. IDO…”
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Oxidative stress, metalloproteinase and LDH in children with intractable and non-intractable epilepsy as reflected in salivary analysis by Shahar, Eli, Attias, Uri, Savulescu, Dana, Genizin, Jacob, Gavish, Moshe, Nagler, Rafael

“…Highlights • Mean salivary LDH and MMP9 concentration decrease in epilepsy patients. • Mean salivary peroxidase, SOD activity and carbonyls increase in…”
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Gonadotropin-Releasing Hormone-Regulated Prohibitin Mediates Apoptosis of the Gonadotrope Cells by Savulescu, Dana, Feng, Jiajun, Ping, Yueh Shyang, Mai, Oliver, Boehm, Ulrich, He, Bin, O'Malley, Bert W, Melamed, Philippa

“…GnRH regulates circulating levels of the gonadotropins but has also been implicated in establishing the gonadotrope cell population. Consistent with this, GnRH…”
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Salivary antioxidants and metalloproteinases in juvenile idiopathic arthritis by Brik, Riva, Rosen, Irit, Savulescu, Dana, Borovoi, Iris, Gavish, Moshe, Nagler, Rafael

“…Juvenile idiopathic arthritis (JIA) is the most common autoimmune inflammatory disease in children; joint inflammation is the hallmark of the disease…”
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Oral cancer, cigarette smoke and mitochondrial 18kDa translocator protein (TSPO) - In vitro, in vivo, salivary analysis by Nagler, Rafael, Ben-Izhak, Ofer, Savulescu, Dana, Krayzler, Ella, Akrish, Sharon, Leschiner, Svetlana, Otradnov, Irina, Zeno, Sivan, Veenman, Leo, Gavish, Moshe

“…Oral cancer features high rates of mortality and morbidity, and is in dire need for new approaches. In the present study we analyzed 18 kDa translocator…”
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Oral cancer, cigarette smoke and mitochondrial 18 kDa translocator protein (TSPO) — In vitro, in vivo, salivary analysis by Nagler, Rafael, Ben-Izhak, Ofer, Savulescu, Dana, Krayzler, Ella, Akrish, Sharon, Leschiner, Svetlana, Otradnov, Irina, Zeno, Sivan, Veenman, Leo, Gavish, Moshe

“…Oral cancer features high rates of mortality and morbidity, and is in dire need for new approaches. In the present study we analyzed 18 kDa translocator…”
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Salivary monitoring related to major surgery by Ullmann, Yehuda, Klein, Yuval, Savulescu, Dana, Borovoi, Iris, Egozi, Dana, Gavish, Moshe, Nagler, Rafael

“…Eur J Clin Invest 2010; 40 (12): 1074–1080 Background  Prolonged surgical procedures involving stress, extended general anaesthesia and a long pre‐surgical…”
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Penicillamine as a potent protector against injurious effects of cigarette smoke in aerodigestive tract cancer by Nagler, Rafael, Cohen, Shiri, Savulescu, Dana, Leschiner, Svetlana, Otradnov, Irina, Gavish, Moshe

“…Cigarette smoke (CS) is the major risk factor for aerodigestive tract cancers such as lung and oral cancers. In in vitro models of lung and oral cancers, we…”
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