An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis

•Immune response gene polymorphisms may be associated with risk of various diseases.•TLR and TREM-1 gene polymorphisms may be associated with IE risk.•TLR6 gene rs3775073 polymorphism may be associated with 2-fold decrease of IE risk.•Other investigated SNPs within TLR and TREM-1 genes are not assoc...

Full description

Saved in:

Bibliographic Details
Published in:	Cytokine (Philadelphia, Pa.) Vol. 71; no. 1; pp. 16 - 21
Main Authors:	Golovkin, Alexey S., Ponasenko, Anastasia V., Yuzhalin, Arseniy E., Salakhov, Ramil R., Khutornaya, Maria V., Kutikhin, Anton G., Rutkovskaya, Natalia V., Savostyanova, Yulia Yu, Barbarash, Leonid S.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-01-2015
Subjects:	Alleles Endocarditis - genetics Endocarditis - immunology Endocarditis - mortality Female Genetic Association Studies - statistics & numerical data Genetic Predisposition to Disease Genotype Healthy Volunteers Humans Immunity, Innate - genetics Infective endocarditis Innate immunity Male Membrane Glycoproteins - genetics Middle Aged Odds Ratio Polymorphism, Single Nucleotide Receptors, Immunologic - genetics Single nucleotide polymorphisms Toll-Like Receptor 6 - genetics Toll-like receptors Toll-Like Receptors - genetics TREM-1 Triggering Receptor Expressed on Myeloid Cells-1 TREM TREM-1 SNP Infective endocarditis Toll-like receptors Innate immunity TLR Single nucleotide polymorphisms IE
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	•Immune response gene polymorphisms may be associated with risk of various diseases.•TLR and TREM-1 gene polymorphisms may be associated with IE risk.•TLR6 gene rs3775073 polymorphism may be associated with 2-fold decrease of IE risk.•Other investigated SNPs within TLR and TREM-1 genes are not associated with IE.•There is no age/gender dependence on association of TLR and TREM-1 SNPs with IE. Infective endocarditis (IE) is an inflammatory condition of the lining of the heart chambers and valves, which is generally caused by bacteria. Toll-like receptors (TLRs) and Triggering receptor expressed on myeloid cells (TREMs) are key effectors of the innate system that play a significant role in the recognition of infectious agents, particularly, bacteria. We hypothesised that inherited variation in TLR and TREM-1 genes may affect individual susceptibility to IE. The distribution of genotypes and alleles of the TLR1 (rs5743551, rs5743611), TLR2 (rs3804099, rs5743708), TLR4 (rs4986790, rs4986791), TLR6 (rs3775073, rs5743810), and TREM-1 (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535, rs2234237) gene polymorphisms was investigated in 110 Caucasian (Russian) subjects with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors. Odds ratios with 95% confidence intervals were calculated. We found that C/C genotype of the rs3775073 polymorphism within TLR6 gene was associated with a decreased risk of IE (OR=0.51, 95% CI=0.26–0.97, P=0.032) according to the recessive model; however, we observed no association between the other investigated SNPs within TLR and TREM-1 genes and IE. Further in-depth investigations in this field are necessary to shed the light on the impact of inherited variation within innate immune response genes on the development of IE.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1043-4666 1096-0023
DOI:	10.1016/j.cyto.2014.08.001