Search Results - "Savoldo, B"

Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity by Liu, E, Tong, Y, Dotti, G, Shaim, H, Savoldo, B, Mukherjee, M, Orange, J, Wan, X, Lu, X, Reynolds, A, Gagea, M, Banerjee, P, Cai, R, Bdaiwi, M H, Basar, R, Muftuoglu, M, Li, L, Marin, D, Wierda, W, Keating, M, Champlin, R, Shpall, E, Rezvani, K

“…Chimeric antigen receptors (CARs) have been used to redirect the specificity of autologous T cells against leukemia and lymphoma with promising clinical…”
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Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma leukemia effects and safety by Hoyos, V, Savoldo, B, Quintarelli, C, Mahendravada, A, Zhang, M, Vera, J, Heslop, H E, Rooney, C M, Brenner, M K, Dotti, G

“…T lymphocytes expressing a chimeric antigen receptor (CAR) targeting the CD19 antigen (CAR.19) may be of value for the therapy of B-cell malignancies. Because…”
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Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant by Weber, G, Gerdemann, U, Caruana, I, Savoldo, B, Hensel, N F, Rabin, K R, Shpall, E J, Melenhorst, J J, Leen, A M, Barrett, A J, Bollard, C M

“…Adoptive immunotherapy with ex vivo expanded T cells is a promising approach to prevent or treat leukemia. Myeloid leukemias express tumor-associated antigens…”
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Immunotherapy in the Treatment of Human Solid Tumors: Basic and Translational Aspects by Olive, D., Savoldo, B., Pastorino, F., Castriconi, R.

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The immunogenicity of virus-derived 2A sequences in immunocompetent individuals by Arber, C, Abhyankar, H, Heslop, H E, Brenner, M K, Liu, H, Dotti, G, Savoldo, B

“…Genetic engineering of T cells for adoptive immunotherapy in cancer patients has shown significant promise. To ensure optimal antitumor activity and safety,…”
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CD30‐CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS FOR THERAPY OF HODGKIN LYMPHOMA (HL) by Ramos, C.A., Torrano, V., Bilgi, M., Gerken, C., Dakhova, O., Mei, Z., Wu, M., Grilley, B., Gee, A.P., Rooney, C.M., Dotti, G., Savoldo, B., Heslop, H.E., Brenner, M.K.

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Direct comparison of in vivo fate of second and third-generation CD19-specific chimeric antigen receptor (CAR)-T cells in patients with b cell non-hodgkin lymphoma (B-NHL): Reversal of toxicity from tonic signaling by Gomes da Silva, D, Mukherjee, M, Madhuwanti, S, Dakhova, O, Liu, H, Grilley, B, Gee, A, Neelapu, S.S, Rooney, C, Heslop, H, Savoldo, B, Dotti, G, Brenner, M, Mamonkin, M, Ramos, C.A

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Late donor cardiectomy after paediatric heterotopic cardiac transplantation by Tsang, V, FRCS, Yacoub, M, Prof, Sridharan, S, Burch, M, FRCP, Radley-Smith, R, FRCP, Khaghani, A, FRCS, Savoldo, B, MD, Amrolia, PJ, FRCP

“…Summary Background Cardiac transplantation is a life-saving procedure in infants and children with advanced cardiomyopathy. However, it is greatly limited by…”
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Chimeric Antigen Receptor Gene-Modified Virus-Specific T-Cell Expanded in Patients with Reactivated Epstein-Barr Virus Post Allogeneic Stem Cell Transplant by Lapteva, N, Gilbert, M, Hiregange, M, Diaconu, I, Dakhova, O, Rouce, R, Rollins, L, Liu, H, Savoldo, B, Durett, A, Krance, R.A, Heslop, H, Gee, A, Ramos, C, Rooney, C

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Generation and administration of autologous T cells transduced with a 3rd generation GD2 chimeric antigen receptor for patients with relapsed or refractory neuroblastoma by Louis, C.U, Savoldo, B, Heczey, A, Yvon, E, Gee, A, Rooney, C, Heslop, H, Dotti, G, Brenner, M.K

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Selective elimination of a chemoresistant side population of B-CLL cells by cytotoxic T lymphocytes in subjects receiving an autologous hCD40L IL-2 tumor vaccine by Foster, A E, Okur, F V, Biagi, E, Lu, A, Dotti, G, Yvon, E, Savoldo, B, Carrum, G, Goodell, M A, Heslop, H E, Brenner, M K

“…Side-population (SP) analysis identifies precursor cells in normal and malignant tissues. Cells with this phenotype have increased resistance to many cytotoxic…”
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Generation of EBV-Specific CD4+ Cytotoxic T Cells from Virus Naive Individuals by Savoldo, Barbara, Cubbage, Michael L, Durett, April G, Goss, John, Huls, M. Helen, Liu, Zhensheng, Teresita, Lopez, Gee, Adrian P, Ling, Paul D, Brenner, Malcolm K, Heslop, Helen E, Rooney, Cliona M

“…Adoptive immunotherapy with EBV-specific CTL (EBV-CTL) effectively prevents and treats EBV-driven lymphoproliferation in immunocompromised hosts…”
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Improving immune reconstitution after cord blood transplantation using ex vivo expanded virus-specific T cells: a phase I clinical study by Hanley, P.J, Martinez, C, Cruz, R, Lam, S, Savoldo, B, Dotti, G, Brenner, M, Rooney, C, Heslop, H, Krance, R, Shpall, E.J, Bollard, C.M

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Ultra low-dose IL-2 mediated expansion of regulatory T cells as GvHD prophylaxis for recipients of allogeneic hematopoietic stem cells by Ku, S, Kennedy-Nasser, A.A, Hazrat, Y, Melenhorst, J, Barrett, A, Ito, S, Durett, A.G, Foster, A, Savoldo, B, Yvon, E, Heslop, H.E, Carrum, G, Kamble, R.T, Brenner, M.K, Krance, R.A, Bollard, C.M

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Naïve T-cell-derived CTL recognize atypical epitopes of CMVpp65 with higher avidity than CMV-seropositive donor-derived CTL - a basis for treatment of post-transplant viral infection by adoptive transfer of T-Cells from virus-naïve donors by Hanley, P.J, Cruz, R.Y, Melenhorst, J, Scheinberg, P, Blaney, J, Savoldo, B, Dotti, G, Heslop, H, Rooney, C, Shpall, E.J, Barrett, J.A, Rodgers, J, Bollard, C.M

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Infusion of CD19-directed/multivirus specific-cytotoxic T lymphocytes after allogeneic hematopoietic stem cell transplantation for B cell malignancies by Cruz, C.R, Micklethwaite, K.P, Savoldo, B, Lam, S, Ku, S, Krance, R.A, Diouf, O, Leen, A.M, Kamble, R.T, Kennedy-Nasser, A, Barrett, J, Shpall, E, Heslop, H.E, Rooney, C.M, Brenner, M.K, Bollard, C.M, Dotti, G

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300 A novel immunotherapy approach for B-CLL by use of Chimeric TCR by Giordano Attianese, G, Hoyos, V, Marin, V, Savoldo, B, Pizzitola, I, Agostoni, V, Parma, M, Biondi, A, Dotti, G, Biagi, E

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Primitive hematopoietic progenitors within mobilized blood are spared by uncontrolled rate freezing by CILLONI, D, GARAU, D, REGAZZI, E, SAMMARELLI, G, SAVOLDO, B, CARAMATTI, C, MANGONI, L, RIZZOLI, V, CARLO-STELLA, C

“…Uncontrolled-rate freezing techniques represent an attractive alternative to controlled-rate cryopreservation procedures which are time-consuming and require…”
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Immunotherapy: B7H3-CAR NK CELLS AND DNR CO-TRANSDUCED NK SHOWS MAINTAIN THEIR POTENCY AGAINST TGF-B MEDIATED IMMUNE SUPPRESSION by Chaudhry, K., Geiger, A., Dowlati, E., Lang, H., Yvon, E., Holdoff, M., Jones, R., Savoldo, B., Cruz, C., Bollard, C.

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Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?" by Dotti, Gianpietro, Savoldo, Barbara, Brenner, Malcolm

“…"T-body" or chimeric antigen receptor (CAR) technology, which combines the specificity of an antibody with the homing, tissue penetration, and target cell…”
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