Search Results - "Savolainen, MJ"

Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide by Astrup, A, Carraro, R, Finer, N, Harper, A, Kunesova, M, Lean, M E J, Niskanen, L, Rasmussen, M F, Rissanen, A, Rössner, S, Savolainen, M J, Van Gaal, L

“…Objective: Having demonstrated short-term weight loss with liraglutide in this group of obese adults, we now evaluate safety/tolerability (primary outcome) and…”
Get full text

Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths by Ruuth, Maija, Nguyen, Su Duy, Vihervaara, Terhi, Hilvo, Mika, Laajala, Teemu D, Kondadi, Pradeep Kumar, Gisterå, Anton, Lähteenmäki, Hanna, Kittilä, Tiia, Huusko, Jenni, Uusitupa, Matti, Schwab, Ursula, Savolainen, Markku J, Sinisalo, Juha, Lokki, Marja-Liisa, Nieminen, Markku S, Jula, Antti, Perola, Markus, Ylä-Herttula, Seppo, Rudel, Lawrence, Öörni, Anssi, Baumann, Marc, Baruch, Amos, Laaksonen, Reijo, Ketelhuth, Daniel F J, Aittokallio, Tero, Jauhiainen, Matti, Käkelä, Reijo, Borén, Jan, Williams, Kevin Jon, Kovanen, Petri T, Öörni, Katariina

“…Abstract Aims Low-density lipoprotein (LDL) particles cause atherosclerotic cardiovascular disease (ASCVD) through their retention, modification, and…”
Get full text

The impact of the leucine 7 to proline 7 polymorphism of the neuropeptide Y gene on postprandial lipemia and on the response of serum total and lipoprotein lipids to a reduced fat diet by SCHWAB, U. S, AGREN, J. J, SAVOLAINEN, M. J, VALVE, R, HALLIKAINEN, M. A, SARKKINEN, E. S, JAUHIAINEN, M, KARVONEN, M. K, PESONEN, U, KOULU, M, UUSITUPA, M. I. J

“…The aim of the study was to examine the impact of the leucine7 to proline7 (Leu7Pro) polymorphism of the NPY gene on postprandial (PP) lipemia, post-heparin…”
Get full text

Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome by Kolehmainen, Marjukka, Ulven, Stine M, Paananen, Jussi, de Mello, Vanessa, Schwab, Ursula, Carlberg, Carsten, Myhrstad, Mari, Pihlajamäki, Jussi, Dungner, Elisabeth, Sjölin, Eva, Gunnarsdottir, Ingibjörg, Cloetens, Lieselotte, Landin-Olsson, Mona, Akesson, Björn, Rosqvist, Fredrik, Hukkanen, Janne, Herzig, Karl-Heinz, Dragsted, Lars O, Savolainen, Markku J, Brader, Lea, Hermansen, Kjeld, Risérus, Ulf, Thorsdottir, Inga, Poutanen, Kaisa S, Uusitupa, Matti, Arner, Peter, Dahlman, Ingrid

“…Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets.Objective: The…”
Get full text

Metabolic changes induced by peroral oestrogen and transdermal oestradiol gel therapy by Karjalainen, A., Heikkinen, J., Savolainen, M. J., Bäckström, A‐C., Salinto, M., Kesäniemi, Y. A.

“…Objective To investigate changes in plasma lipid and lipoprotein levels induced by peroral oestrogen replacement and transdermal oestradiol gel therapy. Design…”
Get full text

Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome--a randomized study by Magnusdottir, Ola Kally, Landberg, Rikard, Gunnarsdottir, Ingibjorg, Cloetens, Lieselotte, Åkesson, Björn, Rosqvist, Fredrik, Schwab, Ursula, Herzig, Karl-Heinz, Hukkanen, Janne, Savolainen, Markku J, Brader, Lea, Hermansen, Kjeld, Kolehmainen, Marjukka, Poutanen, Kaisa, Uusitupa, Matti, Risérus, Ulf, Thorsdottir, Inga

“…Few studies have explored the possible plasma cholesterol lowering effects of rye consumption. The aim of this secondary analysis in the SYSDIET study was to…”
Get full text

High vitreous concentration of IL-6 and IL-8, but not of adhesion molecules in relation to plasma concentrations in proliferative diabetic retinopathy by Koskela, U E, Kuusisto, S M, Nissinen, A E, Savolainen, M J, Liinamaa, M J

“…Inflammatory markers have been observed in proliferative diabetic retinopathy (PDR). We assessed vitreous concentrations of adhesion molecules and cytokines in…”
Get more information

Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub‐Study by Myhrstad, Mari C. W., Mello, Vanessa D., Dahlman, Ingrid, Kolehmainen, Marjukka, Paananen, Jussi, Rundblad, Amanda, Carlberg, Carsten, Olstad, Ole Kristoffer, Pihlajamäki, Jussi, Holven, Kirsten B., Hermansen, Kjeld, Dragsted, Lars O., Gunnarsdottir, Ingibjörg, Cloetens, Lieselotte, Storm, Matilda Ulmius, Åkesson, Björn, Rosqvist, Fredrik, Hukkanen, Janne, Herzig, Karl‐Heinz, Risérus, Ulf, Thorsdottir, Inga, Poutanen, Kaisa S., Savolainen, Markku J, Schwab, Ursula, Arner, Peter, Uusitupa, Matti, Ulven, Stine M.

“…Scope To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with…”
Get full text

An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study by Ulven, Stine M, Holven, Kirsten B, Rundblad, Amanda, Myhrstad, Mari C W, Leder, Lena, Dahlman, Ingrid, Mello, Vanessa D de, Schwab, Ursula, Carlberg, Carsten, Pihlajamäki, Jussi, Hermansen, Kjeld, Dragsted, Lars O, Gunnarsdottir, Ingibjörg, Cloetens, Lieselotte, Åkesson, Björn, Rosqvist, Fredrik, Hukkanen, Janne, Herzig, Karl-Heinz, Savolainen, Markku J, Risérus, Ulf, Thorsdottir, Inga, Poutanen, Kaisa S, Arner, Peter, Uusitupa, Matti, Kolehmainen, Marjukka

“…A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we…”
Get full text

A 4-fold risk of metabolic syndrome in patients with schizophrenia : The Northern Finland 1966 birth cohort study by SAARI, Kaisa M, LINDEMAN, Sari M, VIILO, Kaisa M, ISOHANNI, Matti K, JÄRVELIN, Marjo-Riitta, LAUREN, Liisa H, SAVOLAINEN, Markku J, KOPONEN, Hannu J

“…Schizophrenia is associated with a shortened life expectancy and increased somatic comorbidity with, e.g., cardiovascular disorders. One major risk factor for…”
Get full text

Reduction in the concentration and activity of plasma cholesteryl ester transfer protein by alcohol by Hannuksela, M, Marcel, YL, Kesäniemi, YA, Savolainen, MJ

“…Plasma cholesteryl esters, synthesized within high density lipoproteins (HDL), may be transferred from HDL particles to other lipoproteins by plasma…”
Get full text

Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study by Magnusdottir, O K, Landberg, R, Gunnarsdottir, I, Cloetens, L, Åkesson, B, Landin-Olsson, M, Rosqvist, F, Iggman, D, Schwab, U, Herzig, K-H, Savolainen, M J, Brader, L, Hermansen, K, Kolehmainen, M, Poutanen, K, Uusitupa, M, Thorsdottir, I, Risérus, U

“…Background/Objectives: Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the…”
Get full text

High-density lipoprotein increases the abundance of eNOS protein in human vascular endothelial cells by increasing its half-life by Rämet, Maria E, Rämet, Mika, Lu, Qing, Nickerson, Moriah, Savolainen, Markku J, Malzone, Amy, Karas, Richard H

“…Given the importance of endothelial nitric oxide synthase (eNOS) in regulating endothelium-dependent vasorelaxation, we investigated the effects of…”
Get full text

Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids by Selkälä, Eija M., Kuusisto, Sanna M., Salonurmi, Tuire, Savolainen, Markku J., Jauhiainen, Matti, Pirilä, Päivi L., Kvist, Ari-Pekka, Conzelmann, Ernst, Schmitz, Werner, Alexson, Stefan E., Kotti, Tiina J., Hiltunen, J. Kalervo, Autio, Kaija J.

“…Bile acids play multiple roles in the physiology of vertebrates; they facilitate lipid absorption, serve as signaling molecules to control carbohydrate and…”
Get full text

Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: a SYSDIET sub-study by Leder, Lena, Kolehmainen, Marjukka, Narverud, Ingunn, Dahlman, Ingrid, Myhrstad, Mari C W, de Mello, Vanessa D, Paananen, Jussi, Carlberg, Carsten, Schwab, Ursula, Herzig, Karl-Heinz, Cloetens, Lieselotte, Storm, Matilda Ulmius, Hukkanen, Janne, Savolainen, Markku J, Rosqvist, Fredrik, Hermansen, Kjeld, Dragsted, Lars O, Gunnarsdottir, Ingibjörg, Thorsdottir, Inga, Risérus, Ulf, Åkesson, Björn, Thoresen, Magne, Arner, Peter, Poutanen, Kaisa S, Uusitupa, Matti, Holven, Kirsten B, Ulven, Stine M

“…BACKGROUND: Diet has a great impact on the risk of developing features of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular…”
Get full text

Low plasma antibodies specific for phosphatidylethanol in alcohol abusers and patients with alcoholic pancreatitis by Nissinen, Antti E., Laitinen, L. Maria, Kakko, Sakari, Helander, Anders, Savolainen, Markku J., Hörkkö, Sohvi

“…ABSTRACT Phosphatidylethanol (PEth) is a group of alcohol‐modified phospholipids present in cell membranes after heavy drinking. Our aim was to demonstrate the…”
Get full text

The effects of interleukin‐8, VEGF and CFH polymorphisms on the long‐term response to bevacizumab therapy in exudative age‐related macular degeneration by HAUTAMäKI, A, KIVIOJA, J, VAVULI, S, KAKKO, S, SAVOLAINEN, ER, SAVOLAINEN, MJ, LIINAMAA, MJ, SEITSONEN, S, ONKAMO, P, JÄRVELÄ, I, LUOMA, A, IMMONEN, I

“…Purpose To study the effects of IL‐8, VEGF, CFH, complement component C3 and LOC387715 single nucleotide polymorphisms and neovascular lesion characteristics…”
Get full text

Ghrelin Arg51Gln mutation is a risk factor for Type 2 diabetes and hypertension in a random sample of middle-aged subjects by PÖYKKÖ, S, UKKOLA, O, KAUMA, H, SAVOLAINEN, M. J, KESÄNIEMI, Y. A

“…Experimental studies have suggested that ghrelin, a novel gastrointestinal peptide hormone, could play a role in glucose homeostasis. In addition, ghrelin has…”
Get full text

Prevalence of the metabolic syndrome in drug‐treated hypertensive patients and control subjects by Rantala, A. O., Kauma, H., Lilja, M., Savolainen, M. J., Reunanen, A., Kesäniemi, Y. A.

“…Objectives. To determine the prevalence of the metabolic abnormalities associated with hypertension and to define the predictors of the metabolic syndrome by…”
Get full text

Gamma‐glutamyl transpeptidase and the metabolic syndrome by Rantala, A. O., Lilja, M., Kauma, H., Savolainen, M. J., Reunanen, A., Kesäniemi, Y. A.

“… Rantala AO, Lilja M, Kauma H, Savolainen MJ, Reunanen A, Kesäniemi YA (University of Oulu, Oulu; and The National Public Health Institute, Helsinki,…”
Get full text