Search Results - "Savoia, Claudia"

Extracellular Regulated Kinase Phosphorylates Mitofusin 1 to Control Mitochondrial Morphology and Apoptosis by Pyakurel, Aswin, Savoia, Claudia, Hess, Daniel, Scorrano, Luca

“…Controlled changes in mitochondrial morphology participate in cellular signaling cascades. However, the molecular mechanisms modifying mitochondrial shape are…”
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Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21 by Restelli, Lisa Michelle, Oettinghaus, Björn, Halliday, Mark, Agca, Cavit, Licci, Maria, Sironi, Lara, Savoia, Claudia, Hench, Jürgen, Tolnay, Markus, Neutzner, Albert, Schmidt, Alexander, Eckert, Anne, Mallucci, Giovanna, Scorrano, Luca, Frank, Stephan

“…Stress adaptation is essential for neuronal health. While the fundamental role of mitochondria in neuronal development has been demonstrated, it is still not…”
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DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress by Oettinghaus, Björn, D'Alonzo, Donato, Barbieri, Elisa, Restelli, Lisa Michelle, Savoia, Claudia, Licci, Maria, Tolnay, Markus, Frank, Stephan, Scorrano, Luca

“…During apoptosis mitochondria undergo cristae remodeling and fragmentation, but how the latter relates to outer membrane permeabilization and downstream…”
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Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection by Janda, Elzbieta, Lascala, Antonella, Carresi, Cristina, Parafati, Maddalena, Aprigliano, Serafina, Russo, Vanessa, Savoia, Claudia, Ziviani, Elena, Musolino, Vincenzo, Morani, Federica, Isidoro, Ciro, Mollace, Vincenzo

“…Oxidative stress (OS) stimulates autophagy in different cellular systems, but it remains controversial if this rule can be generalized. We have analyzed the…”
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Knocking-out the Siah2 E3 ubiquitin ligase prevents mitochondrial NCX3 degradation, regulates mitochondrial fission and fusion, and restores mitochondrial function in hypoxic neurons by Sisalli, Maria Josè, Ianniello, Gaetano, Savoia, Claudia, Cuomo, Ornella, Annunziato, Lucio, Scorziello, Antonella

“…Na /Ca  exchanger isoform 3 (NCX3) regulates mitochondrial Ca handling through the outer mitochondrial membrane (OMM) and promotes neuronal survival during…”
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Coordination of GPR40 and Ketogenesis Signaling by Medium Chain Fatty Acids Regulates Beta Cell Function by Pujol, Julien Benjamin, Christinat, Nicolas, Ratinaud, Yann, Savoia, Claudia, Mitchell, Siobhan E, Dioum, El Hadji M

“…Diabetes prevalence increases with age, and β-cell dysfunction contributes to the incidence of the disease. Dietary lipids have been recognized as contributory…”
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Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function by Pujol, Julien B, Heikkila, Eija, Savoia, Claudia, Hajibeigi, Asghar, De Marchi, Umberto, Battiprolu, Pavan K, Öz, Orhan K, Dioum, El Hadji M

“…Pancreatic β-cell dysfunction and death contribute to the onset of diabetes, and novel strategies of β-cell function and survival under diabetogenic conditions…”
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NCX3 regulates mitochondrial calcium handling through AKAP121-anchored signaling complex and prevents hypoxia-induced cell death by Scorziello, Antonella, Savoia, Claudia, Sisalli, Maria Josè, Adornetto, Annagrazia, Secondo, Agnese, Boscia, Francesca, Esposito, Alba, Polishchuk, Elena V., Polishchuk, Roman S., Molinaro, Pasquale, Carlucci, Annalisa, Lignitto, Luca, Di Renzo, Gianfranco, Feliciello, Antonio, Annunziato, Lucio

“…The mitochondrial influx and efflux calcium pathways play a relevant role in cytosolic and mitochondrial calcium homeostasis and contribute to the regulation…”
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NCX3 regulates mitochondrial Ca2+ handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death by Scorziello, Antonella, Savoia, Claudia, Sisalli, Maria Jose, Adornetto, Annagrazia, Secondo, Agnese, Boscia, Francesca, Esposito, Alba, Polishchuk, Elena V, Polishchuk, Roman S, Molinaro, Pasquale, Carlucci, Annalisa, Lignitto, Luca, Di Renzo, Gianfranco, Feliciello, Antonio, Annunziato, Lucio

“…The mitochondrial influx and efflux of Ca2+ play a relevant role in cytosolic and mitochondrial Ca2+ homeostasis, and contribute to the regulation of…”
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NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death by Scorziello, Antonella, Savoia, Claudia, Sisalli, Maria Josè, Adornetto, Annagrazia, Secondo, Agnese, Boscia, Francesca, Esposito, Alba, Polishchuk, Elena V, Polishchuk, Roman S, Molinaro, Pasquale, Carlucci, Annalisa, Lignitto, Luca, Di Renzo, Gianfranco, Feliciello, Antonio, Annunziato, Lucio

“…The mitochondrial influx and efflux of Ca(2+) play a relevant role in cytosolic and mitochondrial Ca(2+) homeostasis, and contribute to the regulation of…”
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Control of PKA stability and signalling by the RING ligase praja2 by Carlucci, Annalisa, Scorziello, Antonella, Feliciello, Antonio, Sepe, Maria, Stefan, Eduard, Savoia, Claudia, Lignitto, Luca, Annunziato, Lucio, Cuomo, Ornella, Nisticò, Robert, Garbi, Corrado

“…Activation of G-protein-coupled receptors (GPCRs) mobilizes compartmentalized pulses of cyclic AMP. The main cellular effector of cAMP is protein kinase A…”
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Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β‑Cells by Kalwat, Michael A, Huang, Zhimin, Wichaidit, Chonlarat, McGlynn, Kathleen, Earnest, Svetlana, Savoia, Claudia, Dioum, Elhadji M, Schneider, Jay W, Hutchison, Michele R, Cobb, Melanie H

“…Novel strategies are needed to modulate β-cell differentiation and function as potential β-cell replacement or restorative therapies for diabetes. We…”
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New insights in mitochondrial calcium handling by sodium/calcium exchanger by Scorziello, Antonella, Savoia, Claudia, Secondo, Agnese, Boscia, Francesca, Sisalli, Maria Josè, Esposito, Alba, Carlucci, Annalisa, Molinaro, Pasquale, Lignitto, Luca, Di Renzo, Gianfranco, Feliciello, Antonio, Annunziato, Lucio

“…Mitochondria are now recognized as one of the main intracellular calcium-storing organelles which play a key role in the intracellular calcium signalling…”
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Rosuvastatin-induced neuroprotection in cortical neurons exposed to OGD/reoxygenation is due to nitric oxide inhibition and ERK1/2 pathway activation by Savoia, Claudia, Sisalli, Maria Jose, Di Renzo, Gianfranco, Annunziato, Lucio, Scorziello, Antonella

“…The aim of the present study was to investigate the molecular mechanisms underlying the neuroprotective effect of the hydrophilic statin rosuvastatin on…”
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