ENTEROBACTERIACAE, PRODUCING ESBLS AND METALLO-β-LACTAMASE NDM-1, ISOLATED IN HOSPITALS OF BALTIC REGION COUNTRIES

ENTEROBACTERIACAE, PRODUCING ESBLS AND METALLO-β-LACTAMASE NDM-1, ISOLATED IN HOSPITALS OF BALTIC REGION COUNTRIES

We studied the prevalence of K. pneumoniae and E. coli resistance to extended spectrum cephalosporins and carbapenems, isolated from patients of eight hospitals in St-Petersburg from January to May, 2012. Prevalence of cephalosporin resistant isolates varied in different hospitals: E. coli – from 7,...

Full description

Saved in:
Bibliographic Details
Published in:Infekt͡s︡ii͡a︡ i immunitet Vol. 3; no. 1; pp. 29 - 36
Main Authors: Egorova, S. A., Kaftyreva, L. A., Lipskaya, L. V., Konovalenko, I. B., Pyasetskaya, M. F., Kurchikova, T. S., Vedernikova, N. B., Morozova, O. T., Smirnova, M. V., Popenko, L. N., Lubushkina, M. I., Savochkina, J. A., Makarova, M. A., Suzhaeva, L. V., Ostankova, J. V., Ivanova, M. N., Pavelkovich, A. M., Naaber, P., Sepp, E., Kõljalg, S., Miciuleviciene, J., Balode, A.
Format: Journal Article
Language:English
Russian
Published: Sankt-Peterburg : NIIÈM imeni Pastera 07-07-2014
Subjects:
e. coli
k. pneumonia
ndm-1
resistance
стх-м
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the prevalence of K. pneumoniae and E. coli resistance to extended spectrum cephalosporins and carbapenems, isolated from patients of eight hospitals in St-Petersburg from January to May, 2012. Prevalence of cephalosporin resistant isolates varied in different hospitals: E. coli – from 7,8 to 50%, K. pneumoniae – from 25,4 to 88,4%. Isolates produced extended spectrum beta-lactamases СТХ-М, mainly СТХ-М-1, also СТХ-М-2 and СТХ-М-9. Twenty two carbapenem-resistant K. pneumoniae strains (also resistant to other antimicrobials) were isolated in three hospitals. MALDI-TOF MS showed that carbapenem resistance was caused by carbapenemase. Carbapenemases of all isolates belonged to metallo-β-lactamases according to results of the ROSCO Diagnostica tests. The gene coding production of New Delhi metallo-β-lactamase (blaNDM-1) were detected in all strains. Our data confirmed that the main cephalosporin resistance mechanism of E. coli и K. pneumoniae in Baltic region (including Russia, St-Petersburg) is CTX-M-1 production. For the first time in Russia K. pneumoniae strains  producing metallo-β-lactamases NDM-1 were isolated in several hospitals of St-Petersburg.
ISSN:2220-7619
2313-7398
DOI:10.15789/2220-7619-2013-1-29-36