Search Results - "Savitz, J"

Neuropathology of mood disorders: do we see the stigmata of inflammation? by Mechawar, N, Savitz, J

“…A proportion of cases with mood disorders have elevated inflammatory markers in the blood that conceivably may result from stress, infection and/or…”
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Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play by Savitz, J B, Rauch, S L, Drevets, W C

“…In response to queries about whether brain imaging technology has reached the point where it is useful for making a clinical diagnosis and for helping to guide…”
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The molecular genetics of cognition: dopamine, COMT and BDNF by Savitz, J., Solms, M., Ramesar, R.

“…The important contribution of genetic factors to the development of cognition and intelligence is widely acknowledged, but identification of these genes has…”
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Imaging phenotypes of major depressive disorder: genetic correlates by Savitz, J.B, Drevets, W.C

“…Abstract Imaging techniques are a potentially powerful method of identifying phenotypes that are associated with, or are indicative of, a vulnerability to…”
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Serum kynurenic acid is reduced in affective psychosis by Wurfel, B E, Drevets, W C, Bliss, S A, McMillin, J R, Suzuki, H, Ford, B N, Morris, H M, Teague, T K, Dantzer, R, Savitz, J B

“…A subgroup of individuals with mood and psychotic disorders shows evidence of inflammation that leads to activation of the kynurenine pathway and the increased…”
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Efficacy and Safety of Paliperidone Extended Release in Adolescents With Schizophrenia: A Randomized, Double-Blind Study by Savitz, Adam J., MD, PhD, Lane, Rosanne, MAS, Nuamah, Isaac, PhD, Gopal, Srihari, MD, MHS, Hough, David, MD

“…Objective To evaluate the efficacy, safety, and tolerability of paliperidone extended release (ER) relative to aripiprazole in adolescent schizophrenia. Method…”
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Efficacy and safety of paliperidone palmitate 3-month formulation in Latin American patients with schizophrenia: A subgroup analysis of data from two large phase 3 randomized, double-blind studies by Savitz, Adam J, Xu, Haiyan, Gopal, Srihari, Nuamah, Isaac, Mathews, Maju, Soares, Bernardo

“…To analyze the efficacy and safety of paliperidone palmitate 3-monthly (PP3M) in Latin American patients with schizophrenia vs. rest-of-world (ROW). We…”
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Diets of Lake Michigan Salmon and Maximum Size of Alewife Prey by Savitz, J.

“…The diets of Lake Michigan salmon were determined by examining stomach contents of sport-caught salmon. The study was conducted from 2001 through 2008 when the…”
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An examination of neurocognition and symptoms as predictors of post-hospital community tenure in treatment resistant schizophrenia by Ahmed, Anthony O, Murphy, Christopher F, Latoussakis, Vassilios, McGovern, Kelly E, English, Judith, Bloch, Andrew, Anthony, Donna T, Savitz, Adam J

“…Abstract Neurocognition and psychopathology are robust predictors of community functioning and relapse/rehospitalization in schizophrenia. Existing studies are…”
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Reproduced from Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study by Savitz, J B, Rauch, S L, Drevets, W C

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Personality endophenotypes for bipolar affective disorder: a family‐based genetic association analysis by Savitz, J., Van Der Merwe, L., Ramesar, R.

“…Genetic analyses of complex conditions such as bipolar disorder (BD) may be facilitated by the use of intermediate phenotypes. Various personality traits are…”
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Opportunities for use of neuroimaging in de-risking drug development and improving clinical outcomes in psychiatry: an industry perspective by Etkin, Amit, Powell, Jessica, Savitz, Adam J.

“…Neuroimaging, across positron emission tomography (PET), electroencephalography (EEG), and magnetic resonance imaging (MRI), has been a mainstay of clinical…”
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Epistasis network centrality analysis yields pathway replication across two GWAS cohorts for bipolar disorder by Pandey, A, Davis, N A, White, B C, Pajewski, N M, Savitz, J, Drevets, W C, McKinney, B A

“…Most pathway and gene-set enrichment methods prioritize genes by their main effect and do not account for variation due to interactions in the pathway. A…”
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Clinical relevance of paliperidone palmitate 3-monthly in treating schizophrenia by Mathews, Maju, Gopal, Srihari, Nuamah, Isaac, Hargarter, Ludger, Savitz, Adam J, Kim, Edward, Tan, Wilson, Soares, Bernardo, Correll, Christoph U

“…Antipsychotics are the mainstay in schizophrenia management, and long-acting injectable (LAI) antipsychotics contribute to the successful maintenance of…”
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Abstract # 1755 Sleep disturbance and kynurenine metabolism in a group of currently depressed, previously depressed, and never depressed subjects by Cho, H.J, Savitz, J, Dantzer, R, Teague, T.K, Drevets, W.C, Irwin, M.R

“…Sleep disturbance is known to increase inflammation. Inflammation may activate the kynurenine metabolic pathway and increase the synthesis of potentially…”
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Comparison of Relapse Prevention with 3 Different Paliperidone Formulations in Patients with Schizophrenia Continuing versus Discontinuing Active Antipsychotic Treatment: A Post-Hoc Analysis of 3 Similarly Designed Randomized Studies by Mathews, Maju, Gopal, Srihari, Singh, Arun, Nuamah, Isaac, Pungor, Katalin, Tan, Wilson, Soares, Bernardo, Kim, Edward, Savitz, Adam J

“…Sudden discontinuation from antipsychotic treatment is a common occurrence in patients with schizophrenia. Lower rates of relapse could be expected for…”
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Predictors of achieving remission in schizophrenia patients treated with paliperidone palmitate 3-month formulation by Nash, Abigail I, Turkoz, Ibrahim, Savitz, Adam J, Mathews, Maju, Kim, Edward

“…Long-acting injectable (LAI) antipsychotic paliperidone palmitate 3-month formulation (PP3M) is indicated in the United States for the treatment of…”
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45. Increased PBMC expression of inflammation and neurological disease-associated genes correlates with anhedonia, the BOLD response to masked happy faces and subgenual anterior cingulate cortex volume in patients with primary mood disorders by Savitz, J, Frank, B, Mckinney, B, Teague, T.K, Drevets, W

“…Mood disorders are characterized by increased proinflammatory activity, anhedonia, abnormal neurophysiological responses to emotionally-valenced faces, and…”
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Lateralization of hand skill in bipolar affective disorder by Savitz, J., Van Der Merwe, L., Solms, M., Ramesar, R.

“…Diverse strands of evidence suggest that schizophrenia is associated with an excess of left and mixed handedness, reflecting anomalous cerebral lateralization…”
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Efficacy and safety of paliperidone palmitate 3-month versus 1-month formulation in patients with schizophrenia: comparison between European and non-European population by Savitz, Adam J, Xu, Haiyan, Gopal, Srihari, Nuamah, Isaac, Ravenstijn, Paulien, Hough, David, Hargarter, Ludger

“…This randomized, double-blind (DB), non-inferiority phase 3 study was conducted to assess the efficacy and safety of paliperidone palmitate 3-month (PP3M) vs…”
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