Navigated transcranial magnetic stimulation in amyotrophic lateral sclerosis

ABSTRACT Introduction: Amyotrophic lateral sclerosis (ALS) is a set of disorders associated with preferential degeneration of both upper and lower motor neurons. Navigated transcranial magnetic stimulation (nTMS) is a tool used to perform noninvasive functional brain mapping. We aimed to assess func...

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Bibliographic Details
Published in:	Muscle & nerve Vol. 51; no. 1; pp. 125 - 131
Main Authors:	Chervyakov, Alexander V., Bakulin, Ilya S., Savitskaya, Natalia G., Arkhipov, Ivan V., Gavrilov, Andrey V., Zakharova, Maria N., Piradov, Michael A.
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-01-2015 Wiley Subscription Services, Inc
Subjects:	Adult Aged ALS Amyotrophic Lateral Sclerosis - complications Amyotrophic Lateral Sclerosis - physiopathology Brain Mapping Electromyography Evoked Potentials, Motor - physiology Humans Magnetic Resonance Imaging Male Middle Aged Motor Neuron Disease - diagnosis Motor Neuron Disease - etiology navigated transcranial magnetic stimulation neurodegeneration Statistics, Nonparametric TMS Transcranial Magnetic Stimulation brain mapping ALS neurodegeneration navigated transcranial magnetic stimulation TMS
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Summary:	ABSTRACT Introduction: Amyotrophic lateral sclerosis (ALS) is a set of disorders associated with preferential degeneration of both upper and lower motor neurons. Navigated transcranial magnetic stimulation (nTMS) is a tool used to perform noninvasive functional brain mapping. We aimed to assess function of upper motor neurons in ALS. Methods: nTMS was performed on 30 patients with ALS (mean age 54.4 ± 12.1 years) and 24 healthy volunteers (mean age 32.7 ± 13.3 years). Results: The resting motor threshold (MT) was significantly higher in ALS patients compared with controls (P < 0.001). The mean map areas were smaller in patients with ALS than in healthy individuals, although some patients with short disease duration had extended maps. Conclusions: Motor area maps serve as markers of upper motor neuron damage in ALS. Further research may elucidate the pathogenic mechanisms of the neurodegenerative process and aid in development of diagnostic and prognostic markers. Muscle Nerve 51: 125–131, 2015
Bibliography:	ark:/67375/WNG-JTC50RCL-J istex:1B576D0F67C290C493CEF655BAA814B7E24FF56E ArticleID:MUS24345 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0148-639X 1097-4598
DOI:	10.1002/mus.24345