Search Results - "Savita Pahwa"

Effects of Aging on Metabolic Characteristics of Human B Cells by Frasca, Daniela, Pallikkuth, Suresh, Pahwa, Savita

“…Metabolic changes represent the most common sign of aging and lead to increased risk of developing diseases typical of old age. Age-associated metabolic…”
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HIV and Aging in the Era of ART and COVID-19 by Pallikkuth, Suresh, Pahwa, Savita

“…Our understanding of HIV/AIDS has been reframed during the recent past because the use of novel antiretroviral therapy has enabled clinicians and patients to…”
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A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses by Pallikkuth, Suresh, Chaudhury, Sidhartha, Lu, Pinyi, Pan, Li, Jongert, Erik, Wille-Reece, Ulrike, Pahwa, Savita

“…Malaria-071, a controlled human malaria infection trial, demonstrated that administration of three doses of RTS,S/AS01 malaria vaccine given at one-month…”
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Differential T-Cell Reactivity to Endemic Coronaviruses and SARS-CoV-2 in Community and Health Care Workers by da Silva Antunes, Ricardo, Pallikkuth, Suresh, Williams, Erin, Dawen Yu, Esther, Mateus, Jose, Quiambao, Lorenzo, Wang, Eric, Rawlings, Stephen A, Stadlbauer, Daniel, Jiang, Kaijun, Amanat, Fatima, Arnold, David, Andrews, David, Fuego, Irma, Dan, Jennifer M, Grifoni, Alba, Weiskopf, Daniela, Krammer, Florian, Crotty, Shane, Hoffer, Michael E, Pahwa, Savita G, Sette, Alessandro

“…Abstract Herein we measured CD4+ T-cell responses against common cold coronaviruses (CCC) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in…”
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HIV and Aging in the Era of ART and COVID-19: Symposium Overview by Montano, Monty, Landay, Alan, Perkins, Molly, Holstad, Marcia, Pallikkuth, Suresh, Pahwa, Savita

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T Follicular Helper Cells and B Cell Dysfunction in Aging and HIV-1 Infection by Pallikkuth, Suresh, de Armas, Lesley, Rinaldi, Stefano, Pahwa, Savita

“…T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo…”
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Metabolic phenotype of B cells from young and elderly HIV individuals by Frasca, Daniela, Pallikkuth, Suresh, Pahwa, Savita

“…Background HIV infection induces inflammaging and chronic immune activation (IA), which are negatively associated with protective humoral immunity. Similar to…”
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An Overview of Miami CDEIPI and a Showcase of Team Science and Cutting-Edge Research Driven by Students by Pallikkuth, Suresh, Andre, Mickensone, Owens, Florida, Davis, Sheldon, Chavez, Jennifer, McDonald, Christian, Raymond, Andrea, El-Hage, Nazira, Carrico, Adam, Shembade, Noula, Chen, Zhibin, Pahwa, Savita

“…The Miami-CFAR Diversity, Equity & Inclusion Pathway Initiative (Miami CDEIPI) is designed to promote a diverse scientific workforce that reflects the…”
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Distinct Molecular Signatures of Aging in Healthy and HIV-Infected Individuals by Rinaldi, Stefano, Pallikkuth, Suresh, De Armas, Lesley, Richardson, Brian, Pan, Li, Pahwa, Rajendra, Williams, Sion, Cameron, Mark, Pahwa, Savita

“…Virally suppressed chronic HIV-infected individuals on antiretroviral therapy experience similar immune impairments as HIV-uninfected elderly. However, they…”
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Dysfunctional peripheral T follicular helper cells dominate in people with impaired influenza vaccine responses: Results from the FLORAH study by Pallikkuth, Suresh, de Armas, Lesley R, Rinaldi, Stefano, George, Varghese K, Pan, Li, Arheart, Kristopher L, Pahwa, Rajendra, Pahwa, Savita

“…Antigen-primed cluster of differentiation (CD) 4+ T follicular helper (Tfh) cells interact with B cells in the germinal centers (GCs) of lymph nodes to…”
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Determinants of health as predictors for differential antibody responses following SARS-CoV-2 primary and booster vaccination in an at-risk, longitudinal cohort by Echeverri Tribin, Felipe, Williams, Erin, Testamarck, Valeska, Carreño, Juan Manuel, Bielak, Dominika, Yellin, Temima, Krammer, Florian, Hoffer, Michael, Pallikkuth, Suresh, Pahwa, Savita

“…Post vaccine immunity following COVID-19 mRNA vaccination may be driven by extrinsic, or controllable and intrinsic, or inherent health factors. Thus, we…”
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Impaired antibody response to influenza vaccine in HIV-infected and uninfected aging women is associated with immune activation and inflammation by Parmigiani, Anita, Alcaide, Maria L, Freguja, Ricardo, Pallikkuth, Suresh, Frasca, Daniela, Fischl, Margaret A, Pahwa, Savita

“…Aging and HIV infection are independently associated with excessive immune activation and impaired immune responses to vaccines, but their relationships have…”
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Serosurvey of Immunity to Monkeypox (Mpox) Virus Antigens in People Living with HIV in South Florida by Kupritz, Jonah, Pahwa, Savita, Pallikkuth, Suresh

“…Mpox is an infectious disease caused by the monkeypox virus (MPXV) belonging to the Orthopoxvirus (OPXV) genus, which includes smallpox and vaccinia virus…”
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Age Associated Microbiome and Microbial Metabolites Modulation and Its Association With Systemic Inflammation in a Rhesus Macaque Model by Pallikkuth, Suresh, Mendez, Roberto, Russell, Kyle, Sirupangi, Tirupataiah, Kvistad, Daniel, Pahwa, Rajendra, Villinger, Francois, Banerjee, Santanu, Pahwa, Savita

“…Aging is associated with declining immunity and inflammation as well as alterations in the gut microbiome with a decrease of beneficial microbes and increase…”
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Single Cell Profiling Reveals PTEN Overexpression in Influenza-Specific B cells in Aging HIV-infected individuals on Anti-retroviral Therapy by de Armas, Lesley R., Pallikkuth, Suresh, Pan, Li, Rinaldi, Stefano, Cotugno, Nicola, Andrews, Sarah, Pahwa, Rajendra, McDermott, Adrian B., Palma, Paolo, Pahwa, Savita

“…Memory B cells (MBC) respond to secondary antigen challenge to protect against infection and to boost immunity following vaccinations. Despite effective…”
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HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells by Hyun, Jinhee, McMahon, Robert S, Lang, Anna L, Edwards, Jasmine S, Badilla, Alejandro Dmitar, Greene, Morgan E, Stone, Geoffrey W, Pallikkuth, Suresh, Stevenson, Mario, Dykxhoorn, Derek M, Kottilil, Shyam, Pahwa, Savita, Thomas, Emmanuel

“…Chronic infection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) affects an estimated 35 million and 75 million individuals worldwide,…”
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Examining the Effect of SARS-CoV-2 Pandemic-Induced Stress and Anxiety on Humoral Immunity in Health Care Workers by Stark, Valerie S, Williams, Erin C, Echeverri Tribin, Felipe, Coto, Jennifer, Carrico, Adam, Carreño, Juan Manuel, Bielak, Dominika, Desai, Parnavi, Krammer, Florian, Hoffer, Michael E, Pallikkuth, Suresh, Pahwa, Savita

“…The effect of stress on vaccine-induced humoral immunity and therapeutic interventions to mitigate pandemic-related stress remain underexplored. Participants…”
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Opioids exacerbate inflammation in people with well-controlled HIV by Dang, Christine M, Nelson, C Mindy, Feaster, Daniel J, Kizhner, Alexander, Forrest, David W, Nakamura, Nobuyo, Iyer, Akshay, Ghanta, Priya P, Jayaweera, Dushyantha T, Rodriguez, Allan E, Pahwa, Rajendra N, Tookes, Hansel E, Pallikkuth, Suresh, Pahwa, Savita G

“…People with HIV (PWH) are known to have underlying inflammation and immune activation despite virologic control. Substance use including opioid dependence is…”
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NIH Workshop on HIV-Associated Comorbidities, Coinfections, and Complications: Summary and Recommendation for Future Research by Pahwa, Savita, Deeks, Steven, Zou, Shimian, Tomitch, Natalie, Miller-Novak, Leia, Caler, Elisabet, Justice, Amy, Sacktor, Ned, Gabuzda, Dana, Hunt, Peter W., Brown, Todd, Kurth, Ann, Baral, Stefan, Mugavero, Michael, Mayer, Kenneth H., Mendenhall, Emily, Detels, Roger, Mutabazi, Vincent

“…With potent antiretroviral therapy and simplified regimens, people living with HIV (PWH) are achieving near-normal lifespans but not necessarily a normal…”
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CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells by Micci, Luca, Alvarez, Xavier, Iriele, Robin I, Ortiz, Alexandra M, Ryan, Emily S, McGary, Colleen S, Deleage, Claire, McAtee, Brigitte B, He, Tianyu, Apetrei, Cristian, Easley, Kirk, Pahwa, Savita, Collman, Ronald G, Derdeyn, Cynthia A, Davenport, Miles P, Estes, Jacob D, Silvestri, Guido, Lackner, Andrew A, Paiardini, Mirko

“…In rhesus macaques (RMs), experimental depletion of CD4+ T-cells prior to SIV infection results in higher viremia and emergence of CD4-independent…”
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