Search Results - "Savio, C."

Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches by Poulin, Jean-Francois, Caronia, Giuliana, Hofer, Caitlyn, Cui, Qiaoling, Helm, Brandon, Ramakrishnan, Charu, Chan, C. Savio, Dombeck, Daniel A., Deisseroth, Karl, Awatramani, Rajeshwar

“…Midbrain dopamine (DA) neurons have diverse functions that can in part be explained by their heterogeneity. Although molecularly distinct subtypes of DA…”
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Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease by Plotkin, Joshua L., Day, Michelle, Peterson, Jayms D., Xie, Zhong, Kress, Geraldine J., Rafalovich, Igor, Kondapalli, Jyothisri, Gertler, Tracy S., Flajolet, Marc, Greengard, Paul, Stavarache, Mihaela, Kaplitt, Michael G., Rosinski, Jim, Chan, C. Savio, Surmeier, D. James

“…Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. The debilitating choreic movements that plague HD patients have been attributed…”
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Cell and circuit complexity of the external globus pallidus by Courtney, Connor D., Pamukcu, Arin, Chan, C. Savio

“…The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing to poor understanding of its cells and circuits. It was assumed that…”
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Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons by Gertler, Tracy S, Chan, C. Savio, Surmeier, D. James

“…Principal medium spiny projection neurons (MSNs) of the striatum have long been thought to be homogeneous in their somatodendritic morphology and physiology…”
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Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia by Fieblinger, Tim, Graves, Steven M., Sebel, Luke E., Alcacer, Cristina, Plotkin, Joshua L., Gertler, Tracy S., Chan, C. Savio, Heiman, Myriam, Greengard, Paul, Cenci, M. Angela, Surmeier, D. James

“…The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID). In these disease states, the…”
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Npas1 + -Nkx2.1 + Neurons Are an Integral Part of the Cortico-pallido-cortical Loop by Abecassis, Zachary A, Berceau, Brianna L, Win, Phyo H, García, Daniela, Xenias, Harry S, Cui, Qiaoling, Pamukcu, Arin, Cherian, Suraj, Hernández, Vivian M, Chon, Uree, Lim, Byung Kook, Kim, Yongsoo, Justice, Nicholas J, Awatramani, Raj, Hooks, Bryan M, Gerfen, Charles R, Boca, Simina M, Chan, C Savio

“…Within the basal ganglia circuit, the external globus pallidus (GPe) is critically involved in motor control. Aside from Foxp2 neurons and ChAT neurons that…”
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Robust Pacemaking in Substantia Nigra Dopaminergic Neurons by Guzman, Jaime N, Sanchez-Padilla, Javier, Chan, C. Savio, Surmeier, D. James

“…Dopaminergic neurons of the substantia nigra pars compacta are autonomous pacemakers. This activity is responsible for the sustained release of dopamine…”
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The external globus pallidus: progress and perspectives by Hegeman, Daniel J., Hong, Ellie S., Hernández, Vivian M., Chan, C. Savio

“…The external globus pallidus (GPe) of the basal ganglia is in a unique and powerful position to influence processing of motor information by virtue of its…”
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Cell type-specific processing of non-motor signals in the external pallidum by Courtney, Connor D., Chan, C. Savio

“…The external globus pallidus (GPe) regulates motor control. However, whether the GPe encodes non-motor information remains unclear. Two recent studies, by…”
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Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain by Troppoli, Timothy A, Yang, Chun, Katsuki, Fumi, Uygun, David S, Lin, Ilyan, Aguilar, David D, Spratt, Tristan, Basheer, Radhika, McNally, James M, Savio Chan, C, McKenna, James T, Brown, Ritchie E

“…Here, we describe a group of basal forebrain (BF) neurons expressing neuronal Per-Arnt-Sim (PAS) domain 1 (Npas1), a developmental transcription factor linked…”
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Parvalbumin + and Npas1 + Pallidal Neurons Have Distinct Circuit Topology and Function by Pamukcu, Arin, Cui, Qiaoling, Xenias, Harry S, Berceau, Brianna L, Augustine, Elizabeth C, Fan, Isabel, Chalasani, Saivasudha, Hantman, Adam W, Lerner, Talia N, Boca, Simina M, Chan, C Savio

“…The external globus pallidus (GPe) is a critical node within the basal ganglia circuit. Phasic changes in the activity of GPe neurons during movement and their…”
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New roles for the external globus pallidus in basal ganglia circuits and behavior by Gittis, Aryn H, Berke, Joshua D, Bevan, Mark D, Chan, C Savio, Mallet, Nicolas, Morrow, Michelle M, Schmidt, Robert

“…The development of methodology to identify specific cell populations and circuits within the basal ganglia is rapidly transforming our ability to understand…”
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Domperidone: Review of Pharmacology and Clinical Applications in Gastroenterology by REDDYMASU, Savio C, SOYKAN, Irfan, MCCALLUM, Richard W

“…Domperidone is a dopamine-2 receptor antagonist. It acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and…”
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'Rejuvenation' protects neurons in mouse models of Parkinson's disease by Tkatch, Tatiana, Chan, C. Savio, Surmeier, D. James, Rick, Caroline, Guzman, Jaime N, Meredith, Gloria E, Ilijic, Ema, Mercer, Jeff N

“…Why dopamine-containing neurons of the brain's substantia nigra pars compacta die in Parkinson's disease has been an enduring mystery. Our studies suggest that…”
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Postpartum contraception: A matter of guidelines by Grandi, Giovanni, Del Savio, Maria C., Tassi, Alice, Facchinetti, Fabio

“…The postpartum period is the perfect time to access family planning services. WHO guidelines contraindicate combined hormonal contraceptives postpartum in…”
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Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus by Chávez, Andrés E, Hernández, Vivian M, Rodenas-Ruano, Alma, Chan, C Savio, Castillo, Pablo E

“…The transient receptor potential TRPV1 or vanilloid receptor is a nonselective ligand-gated channel highly expressed in primary sensory neurons where it…”
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Proliferation of external globus pallidus-subthalamic nucleus synapses following degeneration of midbrain dopamine neurons by Fan, Kai Y, Baufreton, Jérôme, Surmeier, D James, Chan, C Savio, Bevan, Mark D

“…The symptoms of Parkinson's disease (PD) are related to changes in the frequency and pattern of activity in the reciprocally connected GABAergic external…”
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Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus by Hernández, Vivian M, Hegeman, Daniel J, Cui, Qiaoling, Kelver, Daniel A, Fiske, Michael P, Glajch, Kelly E, Pitt, Jason E, Huang, Tina Y, Justice, Nicholas J, Chan, C Savio

“…Compelling evidence suggests that pathological activity of the external globus pallidus (GPe), a nucleus in the basal ganglia, contributes to the motor…”
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Npas1+ Pallidal Neurons Target Striatal Projection Neurons by Glajch, Kelly E, Kelver, Daniel A, Hegeman, Daniel J, Cui, Qiaoling, Xenias, Harry S, Augustine, Elizabeth C, Hernández, Vivian M, Verma, Neha, Huang, Tina Y, Luo, Minmin, Justice, Nicholas J, Chan, C Savio

“…Compelling evidence demonstrates that the external globus pallidus (GPe) plays a key role in processing sensorimotor information. An anatomical projection from…”
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The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus by Biswas, Shiona, Chan, C. Savio, Rubenstein, John L.R., Gan, Lin

“…The external globus pallidus (GPe) is an essential component of the basal ganglia, a group of subcortical nuclei that are involved in control of action…”
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