Search Results - "Savina, Ariel"

Phagocytosis and antigen presentation in dendritic cells by Savina, Ariel, Amigorena, Sebastian

“…Like macrophages and neutrophils, dendritic cells (DCs) are considered professional phagocytes. Even if the three cell types phagocytose parasites, bacteria,…”
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Intracellular mechanisms of antigen cross presentation in dendritic cells by Amigorena, Sebastian, Savina, Ariel

“…The induction of most CD8+ T cell responses by dendritic cells (DCs) requires the presentation of peptides from internalized antigen by class I MHC molecules…”
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Reactive oxygen species production in the phagosome: impact on antigen presentation in dendritic cells by Kotsias, Fiorella, Hoffmann, Eik, Amigorena, Sebastian, Savina, Ariel

“…The NADPH oxidase 2 (NOX2) is known to play a major role in innate immunity for several decades. Phagocytic cells provide host defense by ingesting microbes…”
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Macrophages of distinct origins contribute to tumor development in the lung by Loyher, Pierre-Louis, Hamon, Pauline, Laviron, Marie, Meghraoui-Kheddar, Aïda, Goncalves, Elena, Deng, Zihou, Torstensson, Sara, Bercovici, Nadège, Baudesson de Chanville, Camille, Combadière, Béhazine, Geissmann, Frederic, Savina, Ariel, Combadière, Christophe, Boissonnas, Alexandre

“…Tissue-resident macrophages can self-maintain without contribution of adult hematopoiesis. Herein we show that tissue-resident interstitial macrophages…”
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Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells by Oberkampf, Marine, Guillerey, Camille, Mouriès, Juliette, Rosenbaum, Pierre, Fayolle, Catherine, Bobard, Alexandre, Savina, Ariel, Ogier-Denis, Eric, Enninga, Jost, Amigorena, Sebastian, Leclerc, Claude, Dadaglio, Gilles

“…Cross-presentation allows exogenous antigen presentation in association with major histocompatibility complex class I molecules, a process crucial for the…”
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Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function by Degos, Clara, Heinemann, Mellie, Barrou, Julien, Boucherit, Nicolas, Lambaudie, Eric, Savina, Ariel, Gorvel, Laurent, Olive, Daniel

“…Endometrial Cancer is the most common cancer in the female genital tract in developed countries, and with its increasing incidence due to risk factors such as…”
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IL-26 Confers Proinflammatory Properties to Extracellular DNA by Poli, Caroline, Augusto, Jean François, Dauvé, Jonathan, Adam, Clément, Preisser, Laurence, Larochette, Vincent, Pignon, Pascale, Savina, Ariel, Blanchard, Simon, Subra, Jean François, Chevailler, Alain, Procaccio, Vincent, Croué, Anne, Créminon, Christophe, Morel, Alain, Delneste, Yves, Fickenscher, Helmut, Jeannin, Pascale

“…In physiological conditions, self-DNA released by dying cells is not detected by intracellular DNA sensors. In chronic inflammatory disorders, unabated…”
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Rab27a and Rab27b control different steps of the exosome secretion pathway by Savina, Ariel, Hume, Alistair N, Benaroch, Philippe, Hacohen, Nir, Raposo, Graça, Moita, Luis F, Schauer, Kristine, Darchen, François, Moita, Catarina F, Carmo, Nuno B, Ostrowski, Matias, Fanget, Isabelle, Krumeich, Sophie, Freitas, Rui P, Seabra, Miguel C, Goud, Bruno, Fukuda, Mitsunori, Desnos, Claire, Amigorena, Sebastian, Thery, Clotilde

“…Exosome biogenesis is poorly understood. The small GTPases Rab27a and Rab27b and their effectors, Slp4 and Slac2b, control exosome secretion at different steps…”
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The Small GTPase Rac2 Controls Phagosomal Alkalinization and Antigen Crosspresentation Selectively in CD8 + Dendritic Cells by Savina, Ariel, Peres, Audrey, Cebrian, Ignacio, Carmo, Nuno, Moita, Catarina, Hacohen, Nir, Moita, Luis F., Amigorena, Sebastian

“…A unique subpopulation of spleen dendritic cells (DCs) that express the CD8 surface marker efficiently present phagocytosed antigens to CD8 + T lymphocytes in…”
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NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells by Savina, Ariel, Jancic, Carolina, Hugues, Stephanie, Guermonprez, Pierre, Vargas, Pablo, Moura, Ivan Cruz, Lennon-Duménil, Ana-Maria, Seabra, Miguel C., Raposo, Graça, Amigorena, Sebastian

“…To initiate adaptative cytotoxic immune responses, proteolytic peptides derived from phagocytosed antigens are presented by dendritic cells (DCs) to CD8 + T…”
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Autonomous phagosomal degradation and antigen presentation in dendritic cells by Hoffmann, Eik, Kotsias, Fiorella, Visentin, Géraldine, Bruhns, Pierre, Savina, Ariel, Amigorena, Sebastian

“…Phagocytosis plays a critical role in both innate and adaptive immunity. Phagosomal fusion with late endosomes and lysosomes enhances proteolysis, causing…”
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NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells by Mantegazza, Adriana R., Savina, Ariel, Vermeulen, Mónica, Pérez, Laura, Geffner, Jorge, Hermine, Olivier, Rosenzweig, Sergio D., Faure, Florence, Amigorena, Sebastián

“…The phagocyte NADPH oxidase (NOX2) is critical for the bactericidal activity of phagocytic cells and plays a major role in innate immunity. We showed recently…”
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Sensitization of EGFR Wild-Type Non-Small Cell Lung Cancer Cells to EGFR-Tyrosine Kinase Inhibitor Erlotinib by Raimbourg, Judith, Joalland, Marie-Pierre, Cabart, Mathilde, de Plater, Ludmilla, Bouquet, Fanny, Savina, Ariel, Decaudin, Didier, Bennouna, Jaafar, Vallette, François M, Lalier, Lisenn

“…The benefit of EGFR-TKI in non-small cell lung cancer has been demonstrated in mutant EGFR tumors as first-line treatment but the benefit in wild-type EGFR…”
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Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells by Savina, Ariel, Furlán, Marcelo, Vidal, Michel, Colombo, Maria I.

“…Multivesicular bodies (MVBs) are endocytic structures that contain small vesicles formed by the budding of an endosomal membrane into the lumen of the…”
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The exosome pathway in K562 cells is regulated by Rab11 by Savina, Ariel, Vidal, Michel, Colombo, Maria I

“…During maturation, reticulocytes lose some membrane proteins that are not required on the mature red cell surface. The proteins are released into the…”
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Boosting γδ T cell-mediated antibody-dependent cellular cytotoxicity by PD-1 blockade in follicular lymphoma by Rossi, Cédric, Gravelle, Pauline, Decaup, Emilie, Bordenave, Julie, Poupot, Mary, Tosolini, Marie, Franchini, Don-Marc, Laurent, Camille, Morin, Renaud, Lagarde, Jean-Michel, Ysebaert, Loïc, Ligat, Laetitia, Jean, Christine, Savina, Ariel, Klein, Christian, Céspedes, Alba Matas, Perez-Galan, Patricia, Fournié, Jean-Jacques, Bezombes, Christine

“…Follicular lymphoma (FL) is a common non Hodgkin's lymphoma subtype in which immune escape mechanisms are implicated in resistance to chemo-immunotherapy…”
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Combinations of Bevacizumab and Erlotinib Show Activity in Colorectal Cancer Independent of RAS Status by Mésange, Paul, Bouygues, Anaïs, Ferrand, Nathalie, Sabbah, Michèle, Escargueil, Alexandre E, Savina, Ariel, Chibaudel, Benoist, Tournigand, Christophe, André, Thierry, de Gramont, Aimery, Larsen, Annette K

“…There is extensive cross-talk between VEGF- and EGFR-pathway signaling in colorectal cancer. However, combinations of VEGF- and EGFR-targeted monoclonal…”
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A Tridimensional Model for NK Cell-Mediated ADCC of Follicular Lymphoma by Decaup, Emilie, Rossi, Cédric, Gravelle, Pauline, Laurent, Camille, Bordenave, Julie, Tosolini, Marie, Tourette, Anne, Perrial, Emeline, Dumontet, Charles, Poupot, Mary, Klein, Christian, Savina, Ariel, Fournié, Jean-Jacques, Bezombes, Christine

“…Follicular lymphoma (FL) is the second most frequent subtype of B non-Hodgkin's lymphomas (NHL) for which the treatment is based on the use of anti-CD20 mAbs…”
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Esophageal cancer cells resistant to T-DM1 display alterations in cell adhesion and the prostaglandin pathway by Sauveur, Juliette, Matera, Eva-Laure, Chettab, Kamel, Valet, Philippe, Guitton, Jerome, Savina, Ariel, Dumontet, Charles

“…Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate that specifically targets HER2 thanks to its antibody component trastuzumab. In spite of responses…”
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From 3D spheroids to tumor bearing mice: efficacy and distribution studies of trastuzumab-docetaxel immunoliposome in breast cancer by Rodallec, Anne, Sicard, Guillaume, Giacometti, Sarah, Carré, Manon, Pourroy, Bertrand, Bouquet, Fanny, Savina, Ariel, Lacarelle, Bruno, Ciccolini, Joseph, Fanciullino, Raphaelle

“…Nanoparticles are of rising interest in cancer research, but in vitro canonical cell monolayer models are not suitable to evaluate their efficacy when…”
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