Search Results - "Savin, Kenneth A."

Characteristic Physical Properties and Structural Fragments of Marketed Oral Drugs by Vieth, Michal, Siegel, Miles G, Higgs, Richard E, Watson, Ian A, Robertson, Daniel H, Savin, Kenneth A, Durst, Gregory L, Hipskind, Philip A

“…An increasingly competitive pharmaceutical market demands improvement in the efficiency and probability of drug candidate discovery. Usually these new drug…”
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Use of Samarium Diiodide as an Alternative to Sodium/Mercury Amalgam in the Julia-Lythgoe Olefination by Keck, Gary E, Savin, Kenneth A, Weglarz, Michael A

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A study of the synthesis of triazoles using microwave irradiation by Savin, Kenneth A, Robertson, Michael, Gernert, Doug, Green, Steven, Hembre, Erik J, Bishop, Jessie

“…Herein we describe the conversion of a known [3+2] cycloaddition reaction between an azide and an acetylene from a thermally promoted reaction to a microwave…”
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Effects of Olefin Geometry on the Stereochemistry of Lewis Acid Mediated Additions of Crotylstannanes to Aldehydes by Keck, Gary E, Savin, Kenneth A, Cressman, Erik N. K, Abbott, Duane E

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Desoxyepothilone B is Curative against Human Tumor Xenografts that are Refractory to Paclitaxel by Chou, Ting-Chao, Zhang, Xiu-Guo, Harris, Christina R., Kuduk, Scott D., Balog, Aaron, Savin, Kenneth A., Bertino, Joseph R., Danishefsky, Samuel J.

“…The epothilones are naturally occurring, cytotoxic macrolides that function through a paclitaxel (Taxol)-like mechanism. Although structurally dissimilar, both…”
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Strategies for conducting ADME studies during lead generation in the drug discovery process by Cramer, Jeffrey W, Mattioni, Brian E, Savin, Kenneth A

“…Although the benefit of early ADME screening is widely recognized in the pharmaceutical industry, the implementation of this paradigm is often performed with…”
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Asymmetric Total Synthesis of Rhizoxin D by Keck, Gary E., Wager, Carrie A., Wager, Travis T., Savin, Kenneth A., Covel, Jonathan A., McLaws, Mark D., Krishnamurthy, Dhileep, Cee, Victor J.

“…Catalytic asymmetric allylation (CAA) using tributyl‐(2‐ethylallyl)stannane as a methyl ethyl ketone equivalent plays a key role in this synthesis of rhizoxin…”
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A New Polymer Support Silylene Linking Method for Hindered Hydroxyl-Bearing Systems by Savin, Kenneth A, Woo, Jonathan C. G, Danishefsky, Samuel J

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Pyridine Metallations in the Synthesis of Triazole Based NK-1 Antagonists by N. Jungheim, Louis, Jeff Thrasher, K., J. Hembre, Erik, M. Gardinier, Kevin, A. Savin, Kenneth, Eric Hong, Jian

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Intramolecular Allylstannane-Aldehyde Cyclizations: Stereochemical Results with Flexible Tethers for Reactions Forming Vinylcyclohexanols by Keck, Gary E, Dougherty, Shawn M, Savin, Kenneth A

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Conversion of Allylic Alcohols into Allylic Nitromethyl Compounds via a Palladium-Catalyzed Solvolysis: An Enantioselective Synthesis of an Advanced Carbocyclic Nucleoside Precursor(1) by Deardorff, Donald R., Savin, Kenneth A., Justman, Craig J., Karanjawala, Zarir E., Sheppeck II, James E., Hager, David C., Aydin, Nebil

“…A two-step reaction sequence to homoallylic nitro compounds from allylic alcohols is presented. Ethoxy carbonylation of the alcohols with ethyl chloroformate…”
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Synthetic studies on the rhizoxins. II. An approach to the C10C26 subunit using “substrate directed” allylstannane additions to aldehydes by Keck, Gary E, Savin, Kenneth A, Weglarz, Michael A, Cressman, Erik N.K

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Conversion of Allylic Alcohols into Allylic Nitromethyl Compounds via a Palladium-Catalyzed Solvolysis:  An Enantioselective Synthesis of an Advanced Carbocyclic Nucleoside Precursor1 by Deardorff, Donald R, Savin, Kenneth A, Justman, Craig J, Karanjawala, Zarir E, Sheppeck, James E, Hager, David C, Aydin, Nebil

“…A two-step reaction sequence to homoallylic nitro compounds from allylic alcohols is presented. Ethoxy carbonylation of the alcohols with ethyl chloroformate…”
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Asymmetric Total Synthesis of Rhizoxin D Financial support has been provided by the National Institutes of Health (through grant GM-28961) and by Pfizer, Inc by Keck, Gary E., Wager, Carrie A., Wager, Travis T., Savin, Kenneth A., Covel, Jonathan A., McLaws, Mark D., Krishnamurthy, Dhileep, Cee, Victor J.

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Synthetic studies on the rhizoxins. II. An approach to the C 10C 26 subunit using “substrate directed” allylstannane additions to aldehydes by Keck, Gary E, Savin, Kenneth A, Weglarz, Michael A, Cressman, Erik N.K

“…The construction of a C 10C 26 fragment of the 16-membered antitumor macrolide rhizoxin has been achieved in an efficient manner. The central portion of this…”
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Conversion of Allylic Alcohols into Allylic Nitromethyl Compounds via a Palladium-Catalyzed Solvolysis:  An Enantioselective Synthesis of an Advanced Carbocyclic Nucleoside Precursor 1 by Deardorff, Donald R., Savin, Kenneth A., Justman, Craig J., Karanjawala, Zarir E., Sheppeck, James E., Hager, David C., Aydin, Nebil

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Asymmetric Total Synthesis of Rhizoxin D by Keck, Gary E., Wager, Carrie A., Wager, Travis T., Savin, Kenneth A., Covel, Jonathan A., McLaws, Mark D., Krishnamurthy, Dhileep, Cee, Victor J.

“…Die katalytische asymmetrische Allylierung (KAA) mit Tributyl(2‐ethylallyl)stannan als Ethylmethylketon‐Äquivalent ist eine Schlüsselreaktion bei einer neuen…”
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Asymmetric Total Synthesis of Rhizoxin D by Keck, Gary E., Wager, Carrie A., Wager, Travis T., Savin, Kenneth A., Covel, Jonathan A., McLaws, Mark D., Krishnamurthy, Dhileep, Cee, Victor J.

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