Search Results - "Saville, Stephen P"

Contributions of Candida albicans Dimorphism, Adhesive Interactions, and Extracellular Matrix to the Formation of Dual-Species Biofilms with Streptococcus gordonii by Montelongo-Jauregui, Daniel, Saville, Stephen P, Lopez-Ribot, Jose L

“…Fungal and bacterial populations coexist in the oral cavity, frequently forming mixed-species biofilms that complicate treatment against polymicrobial…”
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Engineered Control of Cell Morphology In Vivo Reveals Distinct Roles for Yeast and Filamentous Forms of Candida albicans during Infection by Saville, Stephen P, Lazzell, Anna L, Monteagudo, Carlos, Lopez-Ribot, Jose L

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Inhibition of Candida albicans Biofilm Formation by Farnesol, a Quorum-Sensing Molecule by Ramage, Gordon, Saville, Stephen P, Wickes, Brian L, López-Ribot, José L

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In Vitro Characterization of a Biaryl Amide Anti-virulence Compound Targeting Candida albicans Filamentation and Biofilm Formation by Romo, Jesus A, Pierce, Christopher G, Esqueda, Marisol, Hung, Chiung-Yu, Saville, Stephen P, Lopez-Ribot, Jose L

“…We have previously identified a small molecule compound, N-[3-(allyloxy)-phenyl]-4-methoxybenzamide (9029936), that exerts potent inhibitory activity against…”
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The Transcriptional Regulator Nrg1p Controls Candida albicans Biofilm Formation and Dispersion by Uppuluri, Priya, Pierce, Christopher G, Thomas, Derek P, Bubeck, Sarah S, Saville, Stephen P, Lopez-Ribot, Jose L

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High-content phenotypic screenings to identify inhibitors of Candida albicans biofilm formation and filamentation by Pierce, Christopher G., Saville, Stephen. P., Lopez-Ribot, Jose L.

“…Abstract Candida species represent the main cause of opportunistic fungal infections worldwide, and Candida albicans remains the most common etiological agent…”
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Candida albicans-Endothelial Cell Interactions : a Key Step in the Pathogenesis of Systemic Candidiasis by GRUBBY, Sarah E. W, MURDOCH, Craig, SUDBERY, Peter E, SAVILLE, Stephen P, LOPEZ-RIBOT, Jose L, THORNHILL, Martin H

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Global Transcriptomic Analysis of the Candida albicans Response to Treatment with a Novel Inhibitor of Filamentation by Romo, Jesus A, Zhang, Hao, Cai, Hong, Kadosh, David, Koehler, Julia R, Saville, Stephen P, Wang, Yufeng, Lopez-Ribot, Jose L

“…The opportunistic pathogenic fungus can cause devastating infections in immunocompromised patients. Its ability to undergo a morphogenetic transition from…”
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Inhibition of Filamentation Can Be Used To Treat Disseminated Candidiasis by SAVILLE, Stephen P, LAZZELL, Anna L, BRYANT, Alexander P, FRETZEN, Angelika, MONREAL, Alex, SOLBERG, Erik O, MONTEAGUDO, Carlos, LOPEZ-RIBOT, Jose L, MILNE, G. Todd

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Candida albicans Morphology-Dependent Host FGF-2 Response as a Potential Therapeutic Target by Vellanki, Sandeep, Huh, Eun Young, Saville, Stephen P, Lee, Soo Chan

“…Angiogenesis mediated by proteins such as Fibroblast Growth Factor-2 (FGF-2) is a vital component of normal physiological processes and has also been…”
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Adhesion of Candida albicans to Endothelial Cells under Physiological Conditions of Flow by Grubb, Sarah E.W, Murdoch, Craig, Sudbery, Peter E, Saville, Stephen P, Lopez-Ribot, Jose L, Thornhill, Martin H

“…Candida albicans is a commensal organism that under certain circumstances can become pathogenic. During systemic infection C. albicans is disseminated via the…”
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Drosophila melanogaster as a Facile Model for Large-Scale Studies of Virulence Mechanisms and Antifungal Drug Efficacy in Candida Species by CHAMILOS, Georgios, LIONAKIS, Michail S, LEWIS, Russell E, LOPEZ-RIBOT, Jose L, SAVILLE, Stephen P, ALBERT, Nathaniel D, HALDER, Georg, KONTOYIANNIS, Dimitrios P

“…Candida species are the predominant fungal pathogens in humans and an important cause of mortality in immunocompromised patients. We developed a model of…”
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WIP regulates N-WASP-mediated actin polymerization and filopodium formation by Geha, Raif S, Martinez-Quiles, Narcisa, Rohatgi, Rajat, Antón, Inés M, Medina, Miguel, Saville, Stephen P, Miki, Hiroaki, Yamaguchi, Hideki, Takenawa, Tadaomi, Hartwig, John H, Ramesh, Narayanaswamy

“…Induction of filopodia is dependent on activation of the small GTPase Cdc42 and on neural Wiskott-Aldrich-syndrome protein (N-WASP). Here we show that…”
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Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant by Cardona, Sandra M., Kim, Sangwon V., Church, Kaira A., Torres, Vanessa O., Cleary, Ian A., Mendiola, Andrew S., Saville, Stephen P., Watowich, Stephanie S., Parker-Thornburg, Jan, Soto-Ospina, Alejandro, Araque, Pedronel, Ransohoff, Richard M., Cardona, Astrid E.

“…Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS) is the leading cause of nontraumatic neurological disability…”
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Efficacy of a Genetically Engineered Candida albicans tet-NRG1 Strain as an Experimental Live Attenuated Vaccine against Hematogenously Disseminated Candidiasis by Saville, Stephen P, Lazzell, Anna L, Chaturvedi, Ashok K, Monteagudo, Carlos, Lopez-Ribot, Jose L

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Use of a Genetically Engineered Strain To Evaluate the Pathogenic Potential of Yeast Cell and Filamentous Forms during Candida albicans Systemic Infection in Immunodeficient Mice by SAVILLE, Stephen P, LAZZELL, Anna L, CHATURVEDI, Ashok K, MONTEAGUDO, Carlos, LOPEZ-RIBOT, Jose L

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Pseudohyphal Regulation by the Transcription Factor Rfg1p in Candida albicans by Cleary, Ian A, Mulabagal, Priyadarshini, Reinhard, Sara M, Yadev, Nishant P, Murdoch, Craig, Thornhill, Martin H, Lazzell, Anna L, Monteagudo, Carlos, Thomas, Derek P, Saville, Stephen P

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Targeting Candida albicans filamentation for antifungal drug development by Vila, Taissa, Romo, Jesus A., Pierce, Christopher G., McHardy, Stanton F., Saville, Stephen P., Lopez-Ribot, José L.

“…Candida albicans remains the main etiological agent of candidiasis, as this otherwise normal commensal of humans is capable of causing active infection in…”
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Validation of the tetracycline regulatable gene expression system for the study of the pathogenesis of infectious disease by Chaturvedi, Ashok K, Lazzell, Anna L, Saville, Stephen P, Wormley, Jr, Floyd L, Monteagudo, Carlos, Lopez-Ribot, Jose L

“…Understanding the pathogenesis of infectious disease requires the examination and successful integration of parameters related to both microbial virulence and…”
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Geldanamycin-Induced Morphological Changes Require Candida albicans Hyphal Growth Regulatory Machinery by Saville, Stephen P., Cleary, Ian A.

“…In Candida albicans , geldanamycin treatment inhibits the essential chaperone Hsp90 and induces a change from yeast to filamentous morphology, likely by…”
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