Search Results - "Saville, M K"

MdmX is a substrate for the deubiquitinating enzyme USP2a by Allende-Vega, N, Sparks, A, Lane, D P, Saville, M K

“…It has previously been shown that ubiquitin-specific protease 2a (USP2a) is a regulator of the Mdm2/p53 pathway. USP2a binds to Mdm2 and can deubiquitinate…”
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p53 is activated in response to disruption of the pre-mRNA splicing machinery by Allende-Vega, N, Dayal, S, Agarwala, U, Sparks, A, Bourdon, J-C, Saville, M K

“…In this study, we show that interfering with the splicing machinery results in activation of the tumour-suppressor p53. The spliceosome was targeted by small…”
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Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53 by ALLENDE-VEGA, N, SAVILLE, M. K, MEEK, D. W

“…The p53 tumour suppressor is regulated mainly by Mdm2, an E3 ubiquitin ligase that promotes the ubiquitylation and proteasome-mediated degradation of p53. Many…”
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Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-κB- and p53-regulated gene targets by McTavish, N, Copeland, L A, Saville, M K, Perkins, N D, Spruce, B A

“…The respective pro- and antiapoptotic functions of the transcription factors p53 and nuclear factor Kappa B (NF- Kappa B), and their potential impact on…”
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The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a by Sparks, A, Dayal, S, Das, J, Robertson, P, Menendez, S, Saville, M K

“…p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degradation. Despite the importance of this in regulating the p53…”
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The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties by SAVILLE, M. K, WATSON, R. J

“…Expression of the B-Myb transcription factor is upregulated during late G1 phase of the cell cycle by an E2F-dependent transcriptional mechanism. B-Myb is…”
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Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity by Xirodimas, Dimitris P, Saville, Mark K, Bourdon, Jean-Christophe, Hay, Ronald T, Lane, David P

“…The only reported role for the conjugation of the NEDD8 ubiquitin-like molecule is control of the activity of SCF ubiquitin ligase complexes. Here, we show…”
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Regulation of endothelin-1- and lysophosphatidic acid-stimulated tyrosine phosphorylation of focal adhesion kinase (pp125fak) in rat-1 fibroblasts by SAVILLE, M. K, GRAHAM, A, MALARKEY, K, PATERSON, A, GOULD, G. W, PLEVIN, R

“…The characteristics of protein tyrosine phosphorylation were examined in Rat-1 fibroblasts in response to endothelin-1 (ET-1) and 1-oleoyl-lysophosphatidic…”
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Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo by XIRODIMAS, Dimitris, SAVILLE, Mark K, EDLING, Charlotte, LANE, David P, LAIN, Sonia

“…Mdm2 has been shown to promote its own ubiquitination and the ubiquitination of the p53 tumour suppressor by virtue of its E3 ubiquitin ligase activity. This…”
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Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms by Stad, Robert, Little, Natalie A, Xirodimas, Dimitris P, Frenk, Ruth, van der Eb, Alex J, Lane, David P, Saville, Mark K, Jochemsen, Aart G

“…The p53 protein maintains genomic integrity through its ability to induce cell cycle arrest or apoptosis in response to various forms of stress. Substantial…”
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Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator by BESSA, Maria, SAVILLE, Mark K, WATSON, Roger J

“…Expression of the B-Myb transcription factor is directed by an E2F-dependent transcriptional mechanism to late G1 and S phases of the cell cycle, where its…”
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B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107 by JOAQUIN, Manel, BESSA, Maria, SAVILLE, Mark K, WATSON, Roger J

“…B-Myb is a cell-cycle regulated transcription factor which is implicated in cell proliferation and has an essential role in early embryonic development. In…”
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B-Myb: a key regulator of the cell cycle by Saville, M K, Watson, R J

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Regulation of the Cell Cycle by B-Myb by Bessa, Maria, Joaquin, Manel, Tavner, Fiona, Saville, Mark K., Watson, Roger J.

“…ABSTRACT B-Myb is a cell-cycle-regulated member of the Myb transcription factor and, like c-Myb, has been implicated in regulation of hematopoietic cell…”
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An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo by MIDGLEY, C. A, DESTERRO, J. M, SAVILLE, M. K, HOWARD, S, SPARKS, A, HAY, R. T, LANE, D. P

“…The p53 tumour suppressor protein is down-regulated by the action of Mdm2, which targets p53 for rapid degradation by the ubiquitin-proteasome pathway. The…”
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Phosphorylation of calmodulin on Tyr99 selectively attenuates the action of calmodulin antagonists on type-I cyclic nucleotide phosphodiesterase activity by SAVILLE, M. K, HOUSLAY, M. D

“…Tyr99 phosphorylation of calmodulin appears to induce a distinct conformational change as is evident from the profound attenuation of the Ca(2+)-induced…”
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p53 isoforms can regulate p53 transcriptional activity by Bourdon, Jean-Christophe, Fernandes, Kenneth, Murray-Zmijewski, Fiona, Liu, Geng, Diot, Alexandra, Xirodimas, Dimitris P, Saville, Mark K, Lane, David P

“…The recently discovered p53-related genes, p73 and p63, express multiple splice variants and N-terminally truncated forms initiated from an alternative…”
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The role of polybasic compounds in determining the tyrosyl phosphorylation of calmodulin by the human insulin receptor by Saville, M K, Houslay, M D

“…A highly purified human insulin receptor preparation was shown to effect receptor autophosphorylation and the phosphorylation of poly(GluTyr) but not that of…”
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Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF- B- and p53-regulated gene targets by McTavish, N, Copeland, L A, Saville, M K, Perkins, N D, Spruce, B A

“…The respective pro- and antiapoptotic functions of the transcription factors p53 and nuclear factor kappaB (NF-kappaB), and their potential impact on…”
Get full text

Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-kappaB- and p53-regulated gene targets by McTavish, N, Copeland, L A, Saville, M K, Perkins, N D, Spruce, B A

“…The respective pro- and antiapoptotic functions of the transcription factors p53 and nuclear factor kappaB (NF-kappaB), and their potential impact on…”
Get full text