Search Results - "Saville, Charis"

Local Arginase 1 Activity Is Required for Cutaneous Wound Healing by Campbell, Laura, Saville, Charis R., Murray, Peter J., Cruickshank, Sheena M., Hardman, Matthew J.

“…Chronic nonhealing wounds in the elderly population are associated with a prolonged and excessive inflammatory response, which is widely hypothesized to impede…”
Get full text

Estrogen Receptor-Alpha Promotes Alternative Macrophage Activation during Cutaneous Repair by Campbell, Laura, Emmerson, Elaine, Williams, Helen, Saville, Charis R., Krust, Andrée, Chambon, Pierre, Mace, Kimberly A., Hardman, Matthew J.

“…Efficient local monocyte/macrophage recruitment is critical for tissue repair. Recruited macrophages are polarized toward classical (proinflammatory) or…”
Get full text

Transitory Shifts in Skin Microbiota Composition and Reductions in Bacterial Load and Psoriasin following Ethanol Perturbation by Saville, Charis R., Metris, Aline, Humphreys, Gavin J., O’Neill, Catherine, Barrett, Paul, Fernandez-Piquer, Judith, McBain, Andrew J.

“…Personal care and hygiene regimens may substantially alter the composition of the skin microbiota through direct and indirect mechanisms. An understanding of…”
Get full text

Estrogen mediates the mechanical properties of skin and prevents elastic fibre degeneration by Saville, Charis R, Derby, Brian, Hardman, Mathew J, Sherratt, Michael J

Get full text

A new family of phosphoinositide phosphatases in microorganisms: identification and biochemical analysis by Beresford, Nicola J, Saville, Charis, Bennett, Hayley J, Roberts, Ian S, Tabernero, Lydia

“…Phosphoinositide metabolism is essential to membrane dynamics and impinges on many cellular processes, including phagocytosis. Modulation of phosphoinositide…”
Get full text

Staphylococcus aureus second immunoglobulin-binding protein drives atopic dermatitis via IL-33 by Al Kindi, Arwa, Williams, Helen, Matsuda, Kenshiro, Alkahtani, Abdullah M., Saville, Charis, Bennett, Hayley, Alshammari, Yasmine, Tan, Soo Y., O’Neill, Catherine, Tanaka, Akane, Matsuda, Hiroshi, Arkwright, Peter D., Pennock, Joanne L.

“…Staphylococcus aureus is the dominant infective trigger of atopic dermatitis (AD). How this bacterium drives type 2 allergic pathology in the absence of…”
Get full text

An Epidermal-Specific Role for Arginase1 during Cutaneous Wound Repair by Crompton, Rachel A., Williams, Helen, Campbell, Laura, Hui Kheng, Lim, Saville, Charis, Ansell, David M., Reid, Adam, Wong, Jason, Vardy, Leah A., Hardman, Matthew J., Cruickshank, Sheena M.

“…Nonhealing wounds are a major area of unmet clinical need remaining problematic to treat. Improved understanding of prohealing mechanisms is invaluable. The…”
Get full text

Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo by Vickers, Clare F, Silva, Ana P. G, Chakraborty, Ajanta, Fernandez, Paulina, Kurepina, Natalia, Saville, Charis, Naranjo, Yandi, Pons, Miquel, Schnettger, Laura S, Gutierrez, Maximiliano G, Park, Steven, Kreiswith, Barry N, Perlin, David S, Thomas, Eric J, Cavet, Jennifer S, Tabernero, Lydia

“…Mycobacterium tuberculosis protein-tyrosine-phosphatase B (MptpB) is a secreted virulence factor that subverts antimicrobial activity in the host. We report…”
Get full text

Structure-based design of MptpB inhibitors that reduce multi-drug-resistant mycobacterium tuberculosis survival and infection burden in vivo by Vickers, Clare F, Silva, Ana P.G, Chakraborty, Ajanta, Fernandez, Paulina, Kurepina, Natalia, Saville, Charis, Naranjo, Yandi, Pons Vallès, Miquel, Schnettger, Laura S, Gutierrez, Maximiliano G, Park, Steven, Keiswirth, Barry N, Perlin, David S, Thomas, Eric J, Cavet, Jennifer S, Tabernero, Lydia

“…Mycobacterium tuberculosis protein-tyrosine-phosphatase B (MptpB) is a secreted virulence factor that subverts antimicrobial activity in the host. We report…”
Get full text

Hormonal Modulation of Ageing Skin Microstructure and Mechanical Properties by Saville, Charis R

“…Ageing tissue is characterised by an alteration in mechanical properties, with tissues becoming increasingly fragile, stiff and less resilient over time. This…”
Get full text