Search Results - "Savill, John"

Resolution of inflammation: the beginning programs the end by Savill, John, Serhan, Charles N

“…Acute inflammation normally resolves by mechanisms that have remained somewhat elusive. Emerging evidence now suggests that an active, coordinated program of…”
Get full text

tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells by Miles, Katherine, Heaney, Jonathan, Sibinska, Zaneta, Salter, Donald, Savill, John, Gray, David, Gray, Mohini

“…Intracellular protein complexes containing nucleic acids are common targets of autoantibodies in many autoimmune diseases. Central tolerance to these antigens…”
Get full text

Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation by Chapman, Karen E., Coutinho, Agnes E., Zhang, Zhenguang, Kipari, Tiina, Savill, John S., Seckl, Jonathan R.

“…► 11β-HSD1 converts inert glucocorticoids into active forms, amplifying glucocorticoid action. ► 11β-HSD1 is markedly induced by pro-inflammatory cytokines. ►…”
Get full text

Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin αv and TGF-β activation by Zhang, Ailiang, Paidassi, Helena, Lacy-Hulbert, Adam, Savill, John

“…In the mammalian gut CD103+ve myeloid DCs are known to suppress inflammation threatened by luminal bacteria, but stimuli driving DC precursor maturation…”
Get full text

A blast from the past: clearance of apoptotic cells regulates immune responses by Savill, John, Dransfield, Ian, Gregory, Chris, Haslett, Chris

“…Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes…”
Get full text

Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis by Rossi, Adriano G, Sawatzky, Deborah A, Walker, Annemieke, Ward, Carol, Sheldrake, Tara A, Riley, Nicola A, Caldicott, Alison, Martinez-Losa, Magdalena, Walker, Trevor R, Duffin, Rodger, Gray, Mohini, Crescenzi, Elvira, Martin, Morag C, Brady, Hugh J, Savill, John S, Dransfield, Ian, Haslett, Christopher

“…Apoptosis is essential for clearance of potentially injurious inflammatory cells and subsequent efficient resolution of inflammation. Here we report that human…”
Get full text

Ulcerative colitis and autoimmunity induced by loss of myeloid αv integrins by Lacy-Hulbert, Adam, Smith, Aileen M, Tissire, Hamid, Barry, Marc, Crowley, Denise, Bronson, Roderick T, Roes, Jürgen T, Savill, John S, Hynes, Richard O

“…The gastrointestinal tract is constantly challenged by foreign antigens and commensal bacteria but nonetheless is able to maintain a state of immunological…”
Get full text

Apoptosis in resolution of inflammation by Savill, John

“…The last few years have seen the accumulation of compelling evidence that apoptosis (programmed cell death) plays a major role in promoting resolution of the…”
Get full text

αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells by Acharya, Mridu, Sokolovska, Anna, Tam, Jenny M., Conway, Kara L., Stefani, Caroline, Raso, Fiona, Mukhopadhyay, Subhankar, Feliu, Marianela, Paul, Elahna, Savill, John, Hynes, Richard O., Xavier, Ramnik J., Vyas, Jatin M., Stuart, Lynda M., Lacy-Hulbert, Adam

“…Integrin signalling triggers cytoskeletal rearrangements, including endocytosis and exocytosis of integrins and other membrane proteins. In addition to…”
Get full text

11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice by Coutinho, Agnes E, Gray, Mohini, Brownstein, David G, Salter, Donald M, Sawatzky, Deborah A, Clay, Spike, Gilmour, James S, Seckl, Jonathan R, Savill, John S, Chapman, Karen E

“…Glucocorticoids profoundly influence immune responses, and synthetic glucocorticoids are widely used clinically for their potent antiinflammatory effects…”
Get full text

11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice by Coutinho, Agnes E, Kipari, Tiina M. J, Zhang, Zhenguang, Esteves, Cristina L, Lucas, Christopher D, Gilmour, James S, Webster, Scott P, Walker, Brian R, Hughes, Jeremy, Savill, John S, Seckl, Jonathan R, Rossi, Adriano G, Chapman, Karen E

“…Endogenous glucocorticoid action within cells is enhanced by prereceptor metabolism by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts…”
Get full text

Apoptotic Cells Protect Mice against Lipopolysaccharide-Induced Shock by Ren, Yi, Xie, Yi, Jiang, Guoping, Fan, Jianqing, Yeung, Joseph, Li, Wen, Tam, Paul K. H, Savill, John

“…LPS is a main causative agent of septic shock. There is a lack of effective therapies. In vitro studies have shown that uptake of apoptotic cells actively…”
Get full text

Mast cells express 11β-hydroxysteroid dehydrogenase type 1: a role in restraining mast cell degranulation by Coutinho, Agnes E, Brown, Jeremy K, Yang, Fu, Brownstein, David G, Gray, Mohini, Seckl, Jonathan R, Savill, John S, Chapman, Karen E

“…Mast cells are key initiators of allergic, anaphylactic and inflammatory reactions, producing mediators that affect vascular permeability, angiogenesis and…”
Get full text

Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy by Findlay, Emily Gwyer, Currie, Andrew J., Zhang, Ailiang, Ovciarikova, Jana, Young, Lisa, Stevens, Holly, McHugh, Brian J., Canel, Marta, Gray, Mohini, Milling, Simon W.F., Campbell, John D.M., Savill, John, Serrels, Alan, Davidson, Donald J.

“…Immunization of patients with autologous, ex vivo matured dendritic cell (DC) preparations, in order to prime antitumor T-cell responses, is the focus of…”
Get full text

Requirements for Apoptotic Cell Contact in Regulation of Macrophage Responses by Lucas, Mark, Stuart, Lynda M, Zhang, Ailiang, Hodivala-Dilke, Kairbaan, Febbraio, Maria, Silverstein, Roy, Savill, John, Lacy-Hulbert, Adam

“…An important consequence of macrophage engulfment of apoptotic cells is suppression of inflammatory responses, which was first defined by assay of TNF-alpha…”
Get full text

Apoptotic Cells and Innate Immune Stimuli Combine to Regulate Macrophage Cytokine Secretion by Lucas, Mark, Stuart, Lynda M, Savill, John, Lacy-Hulbert, Adam

“…Macrophage interactions with apoptotic cells can suppress inflammatory responses, but cell death by apoptosis may also trigger inflammation. We now report that…”
Get full text

The role and regulation of 11β-hydroxysteroid dehydrogenase type 1 in the inflammatory response by Chapman, Karen E., Coutinho, Agnes E., Gray, Mohini, Gilmour, James S., Savill, John S., Seckl, Jonathan R.

“…Cortisone, a glucocorticoid hormone, was first used to treat rheumatoid arthritis in humans in the late 1940s, for which Hench, Reichstein and Kendall were…”
Get full text

11β‐hydroxysteroid dehydrogenase type 1 deficiency in bone marrow‐derived cells reduces atherosclerosis by Kipari, Tiina, Hadoke, Patrick W. F., Iqbal, Javaid, Man, Tak‐Yung, Miller, Eileen, Coutinho, Agnes E., Zhang, Zhenguang, Sullivan, Katie M., Mitic, Tijana, Livingstone, Dawn E. W., Schrecker, Christopher, Samuel, Kay, White, Christopher I., Bouhlel, M. Amine, Chinetti‐Gbaguidi, Giulia, Staels, Bart, Andrew, Ruth, Walker, Brian R., Savill, John S., Chapman, Karen E., Seckl, Jonathan R.

“…11β‐Hydroxysteroid dehydrogenase type‐1 (11β‐HSD1) converts inert cortisone into active cortisol, amplifying intracellular glucocorticoid action. 11β‐HSD1…”
Get full text

Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes by Gilmour, James S, Coutinho, Agnes E, Cailhier, Jean-François, Man, Tak Yung, Clay, Michael, Thomas, Graham, Harris, Hayley J, Mullins, John J, Seckl, Jonathan R, Savill, John S, Chapman, Karen E

“…Glucocorticoids promote macrophage phagocytosis of leukocytes undergoing apoptosis. Prereceptor metabolism of glucocorticoids by 11beta-hydroxysteroid…”
Get full text

Mastering Microsoft Azure Infrastructure Services by Savill, John

“…Understand, create, deploy, and maintain a public cloud using Microsoft Azure Mastering Microsoft Azure Infrastructure Services guides you through the process…”
Get full text