Search Results - "Saviano, Michele"

Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study by Creanza, Teresa Maria, Delre, Pietro, Ancona, Nicola, Lentini, Giovanni, Saviano, Michele, Mangiatordi, Giuseppe Felice

“…Drug-induced blockade of the human ether-à-go-go-related gene (hERG) channel is today considered the main cause of cardiotoxicity in postmarketing…”
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A Global Review on Short Peptides: Frontiers and Perspectives by Apostolopoulos, Vasso, Bojarska, Joanna, Chai, Tsun-Thai, Elnagdy, Sherif, Kaczmarek, Krzysztof, Matsoukas, John, New, Roger, Parang, Keykavous, Lopez, Octavio Paredes, Parhiz, Hamideh, Perera, Conrad O, Pickholz, Monica, Remko, Milan, Saviano, Michele, Skwarczynski, Mariusz, Tang, Yefeng, Wolf, Wojciech M, Yoshiya, Taku, Zabrocki, Janusz, Zielenkiewicz, Piotr, AlKhazindar, Maha, Barriga, Vanessa, Kelaidonis, Konstantinos, Sarasia, Elham Mousavinezhad, Toth, Istvan

“…Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with…”
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Peptide-Protein Interactions: From Drug Design to Supramolecular Biomaterials by Caporale, Andrea, Adorinni, Simone, Lamba, Doriano, Saviano, Michele

“…The self-recognition and self-assembly of biomolecules are spontaneous processes that occur in Nature and allow the formation of ordered structures, at the…”
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Zeolites as Acid/Basic Solid Catalysts: Recent Synthetic Developments by Valentina Verdoliva, Michele Saviano, Stefania De Luca

“…The zeolites are porous solid structures characterized by a particular framework of aluminosilicates, in which the incorporation of the Al+3 ions generates an…”
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An Overview of Peptide-Based Molecules as Potential Drug Candidates for Multiple Sclerosis by Del Gatto, Annarita, Saviano, Michele, Zaccaro, Laura

“…Multiple sclerosis (MS) belongs to demyelinating diseases, which are progressive and highly debilitating pathologies that imply a high burden both on…”
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Repurposing Known Drugs as Covalent and Non-covalent Inhibitors of the SARS-CoV-2 Papain-Like Protease by Delre, Pietro, Caporuscio, Fabiana, Saviano, Michele, Mangiatordi, Giuseppe Felice

“…In the absence of an approved vaccine, developing effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals is essential to tackle the…”
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Peptoids: Smart and Emerging Candidates for the Diagnosis of Cancer, Neurological and Autoimmune Disorders by Giorgio, Anna, Del Gatto, Annarita, Pennacchio, Simone, Saviano, Michele, Zaccaro, Laura

“…Early detection of fatal and disabling diseases such as cancer, neurological and autoimmune dysfunctions is still desirable yet challenging to improve quality…”
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Microwave Heating Promotes the S-Alkylation of Aziridine Catalyzed by Molecular Sieves: A Post-Synthetic Approach to Lanthionine-Containing Peptides by Verdoliva, Valentina, Digilio, Giuseppe, Saviano, Michele, De Luca, Stefania

“…Aziridine derivatives involved in nucleophilic ring-opening reactions have attracted great interest, since they allow the preparation of biologically active…”
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A Comparative Molecular Dynamics Study of Selected Point Mutations in the Shwachman–Bodian–Diamond Syndrome Protein SBDS by Spinetti, Elena, Delre, Pietro, Saviano, Michele, Siliqi, Dritan, Lattanzi, Gianluca, Mangiatordi, Giuseppe Felice

“…The Shwachman–Diamond Syndrome (SDS) is an autosomal recessive disease whose majority of patients display mutations in a ribosome assembly protein named…”
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Natural and Synthetic Halogenated Amino Acids-Structural and Bioactive Features in Antimicrobial Peptides and Peptidomimetics by Mardirossian, Mario, Rubini, Marina, Adamo, Mauro F A, Scocchi, Marco, Saviano, Michele, Tossi, Alessandro, Gennaro, Renato, Caporale, Andrea

“…The 3D structure and surface characteristics of proteins and peptides are crucial for interactions with receptors or ligands and can be modified to some extent…”
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Correction: Verdoliva et al. Zeolites as Acid/Basic Solid Catalysts: Recent Synthetic Developments. Catalysts 2019, 9, 248 by Valentina Verdoliva, Michele Saviano, Stefania De Luca

“…The authors wish to make the following correction to this paper [...]…”
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Advances in Nucleic Acid Research: Exploring the Potential of Oligonucleotides for Therapeutic Applications and Biological Studies by Moccia, Maria, Pascucci, Barbara, Saviano, Michele, Cerasa, Maria Teresa, Terzidis, Michael A, Chatgilialoglu, Chryssostomos, Masi, Annalisa

“…In recent years, nucleic acids have emerged as powerful biomaterials, revolutionizing the field of biomedicine. This review explores the multifaceted…”
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More Is Always Better Than One: The N-Terminal Domain of the Spike Protein as Another Emerging Target for Hampering the SARS-CoV-2 Attachment to Host Cells by Di Gaetano, Sonia, Capasso, Domenica, Delre, Pietro, Pirone, Luciano, Saviano, Michele, Pedone, Emilia, Mangiatordi, Giuseppe Felice

“…Although the approved vaccines are proving to be of utmost importance in containing the Coronavirus disease 2019 (COVID-19) threat, they will hardly be…”
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Design, Synthesis, and Anticancer Activity of a Selenium-Containing Galectin-3 and Galectin-9N Inhibitor by Di Gaetano, Sonia, Pirone, Luciano, Galdadas, Ioannis, Traboni, Serena, Iadonisi, Alfonso, Pedone, Emilia, Saviano, Michele, Gervasio, Francesco Luigi, Capasso, Domenica

“…Galectins are soluble β-D-galactoside-binding proteins whose implication in cancer progression and disease outcome makes them prominent targets for therapeutic…”
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Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders by Pepe, Giuseppe, Calce, Enrica, Verdoliva, Valentina, Saviano, Michele, Maglione, Vittorio, Di Pardo, Alba, De Luca, Stefania

“…Identification of molecules able to promote neuroprotective mechanisms can represent a promising therapeutic approach to neurodegenerative disorders including…”
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Silver (I) N -Heterocyclic Carbene Complexes: A Winning and Broad Spectrum of Antimicrobial Properties by Prencipe, Filippo, Zanfardino, Anna, Di Napoli, Michela, Rossi, Filomena, D'Errico, Stefano, Piccialli, Gennaro, Mangiatordi, Giuseppe Felice, Saviano, Michele, Ronga, Luisa, Varcamonti, Mario, Tesauro, Diego

“…The evolution of antibacterial resistance has arisen as the main downside in fighting bacterial infections pushing researchers to develop novel, more potent…”
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Ligand-based prediction of hERG-mediated cardiotoxicity based on the integration of different machine learning techniques by Delre, Pietro, Lavado, Giovanna J., Lamanna, Giuseppe, Saviano, Michele, Roncaglioni, Alessandra, Benfenati, Emilio, Mangiatordi, Giuseppe Felice, Gadaleta, Domenico

“…Drug-induced cardiotoxicity is a common side effect of drugs in clinical use or under postmarket surveillance and is commonly due to off-target interactions…”
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A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach by Abatematteo, Francesca Serena, Delre, Pietro, Mercurio, Ivan, Rezelj, Veronica V., Siliqi, Dritan, Beaucourt, Stephanie, Lattanzi, Gianluca, Colabufo, Nicola Antonio, Leopoldo, Marcello, Saviano, Michele, Vignuzzi, Marco, Mangiatordi, Giuseppe Felice, Abate, Carmen

“…The development of effective drugs to treat coronavirus infections remains a significant challenge for the scientific community. Recent evidence reports on the…”
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Biophysical and Structural Characterization of the Interaction between Human Galectin-3 and the Lipopolysaccharide from Pseudomonas aeruginosa by Pirone, Luciano, Lenza, Maria Pia, Di Gaetano, Sonia, Capasso, Domenica, Filocaso, Martina, Russo, Rita, Di Carluccio, Cristina, Saviano, Michele, Silipo, Alba, Pedone, Emilia

“…Given the significant involvement of galectins in the development of numerous diseases, the aim of the following work is to further study the interaction…”
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The Biological Action and Structural Characterization of Eryngitin 3 and 4, Ribotoxin-like Proteins from Pleurotus eryngii Fruiting Bodies by Ragucci, Sara, Landi, Nicola, Citores, Lucía, Iglesias, Rosario, Russo, Rosita, Clemente, Angela, Saviano, Michele, Pedone, Paolo Vincenzo, Chambery, Angela, Ferreras, José Miguel, Di Maro, Antimo

“…Ribotoxin-like proteins (RL-Ps) are specific ribonucleases found in mushrooms that are able to cleave a single phosphodiester bond located in the sarcin–ricin…”
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