Search Results - "Saviano, Alessandro Morais"

Measurement uncertainty in pharmaceutical analysis and its application by Traple, Marcus Augusto Lyrio, Saviano, Alessandro Morais, Francisco, Fabiane Lacerda, Lourenço, Felipe Rebello

“…The measurement uncertainty provides complete information about an analytical result. This is very important because several decisions of compliance or…”
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Design of Experiments (DoE) applied to Pharmaceutical and Analytical Quality by Design (QbD) by Fukuda, Isa Martins, Pinto, Camila Francini Fidelis, Moreira, Camila dos Santos, Saviano, Alessandro Morais, Lourenço, Felipe Rebello

“…According to Quality by Design (QbD) concept, quality should be built into product/method during pharmaceutical/analytical development. Usually, there are many…”
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Determination of cocaine and cocaethylene in urine by solid-phase microextraction and gas chromatography-mass spectrometry by Yonamine, Mauricio, Saviano, Alessandro Morais

“…In order to evaluate recent cocaine exposure or its coingestion with ethanol, a simple and sensitive solid‐phase microextraction (SPME) procedure for…”
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Rapid microbiological methods (RMMs) for evaluating the activity of cephalosporin antibiotics employing triphenyltetrazolium chloride by Saviano, Alessandro Morais, Lourenço, Felipe Rebello

“…Agar diffusion method has been used to evaluate antimicrobial activity since the discovery of penicillin. Nevertheless, little progress has occurred in…”
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Measurement uncertainty estimation based on multiple regression analysis (MRA) and Monte Carlo (MC) simulations – Application to agar diffusion method by Saviano, Alessandro Morais, Lourenço, Felipe Rebello

“…[Display omitted] •Inhibition zone sizes were expressed as functions of analytical conditions using MRA.•Sources of uncertainty were identified and quantified…”
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Using image analysis to determine gentamicin potency by agar diffusion microbiological assay and its measurement uncertainty by Saviano, Alessandro Morais, Lourenço, Felipe Rebello

“…•Microbiological assay conditions were optimized using design of experiments.•Inhibition zone sizes were measured using ImageJ software for image…”
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Using measurement uncertainty to assess the fitness for purpose of an HPLC analytical method in the pharmaceutical industry by Separovic, Luciana, Saviano, Alessandro Morais, Lourenço, Felipe Rebello

“…•The measurement uncertainty of HPLC assay of amoxicillin tablets was estimated.•Assessment of process capability showed manufacturing process under…”
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Rational development and validation of a new microbiological assay for linezolid and its measurement uncertainty by Saviano, Alessandro Morais, Francisco, Fabiane Lacerda, Lourenço, Felipe Rebello

“…The aim of this work was to develop and validate a new microbiological assay to determine potency of linezolid in injectable solution. 24 factorial and central…”
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Measurement uncertainty for the potency estimation by rapid microbiological methods (RMMs) with correlated data by Saviano, Alessandro Morais, Bettencourt da Silva, Ricardo J.N., Lourenço, Felipe Rebello

“…Recently, rapid microbiological methods (RMM) have often been used to determinate the potency of antibiotic drugs. Since all the standard and sample…”
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Measuring Uncertainty Using Different Approaches: A Case Study for Acetaminophen Quantification by Francisco, Fabiane Lacerda, Saviano, Alessandro Morais, Lourenco, Felipe Rebello

“…Investigation of out-of-specification analytical results is laborious, time-consuming, and costly and must be well documented. However, an analytical result is…”
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Kinetic microplate bioassays for relative potency of antibiotics improved by partial Least Square (PLS) regression by Francisco, Fabiane Lacerda, Saviano, Alessandro Morais, Almeida, Túlia de Souza Botelho, Lourenço, Felipe Rebello

“…Microbiological assays are widely used to estimate the relative potencies of antibiotics in order to guarantee the efficacy, safety, and quality of drug…”
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Development, optimization and validation of a rapid colorimetric microplate bioassay for neomycin sulfate in pharmaceutical drug products by Francisco, Fabiane Lacerda, Saviano, Alessandro Morais, Pinto, Terezinha de Jesus Andreoli, Lourenço, Felipe Rebello

“…Microbiological assays have been used to evaluate antimicrobial activity since the discovery of the first antibiotics. Despite their limitations,…”
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Uncertainty evaluation for determining linezolid in injectable solution by UV spectrophotometry by Saviano, Alessandro Morais, Lourenço, Felipe Rebello

“…[Display omitted] •We identify several sources of uncertainty in quantification of linezolid.•We evaluate how each uncertainty source contributes to total…”
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Conformity Decisions Based on Measurement Uncertainty—a Case Study Applied to Agar Diffusion Microbiological Assay by Separovic, Luciana, de Godoy Bertanha, Maria Luiza, Saviano, Alessandro Morais, Lourenço, Felipe Rebello

“…Purpose Antimicrobial activity of drug products containing antibiotics is often measured using microbiological assays. However, the high values of measurement…”
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Measurement uncertainty of a UPLC stability indicating method for determination of linezolid in dosage forms by Saviano, Alessandro Morais, Madruga, Raquel Omegna Gago, Lourenço, Felipe Rebello

“…[Display omitted] •We validated a UPLC method for quantification of linezolid.•We identified several sources of uncertainty in quantification of linezolid.•We…”
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Development, Optimization, and Validation of a Microplate Bioassay for Relative Potency Determination of Linezolid Using a Design Space Concept, and its Measurement Uncertainty by Saviano, Alessandro Morais, Francisco, Fabiane Lacerda, Ostronoff, Celina Silva, Lourenço, Felipe Rebello

“…The aim of this study was to develop, optimize, and validate a microplate bioassay for relative potency determination of linezolid in pharmaceutical samples…”
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Compatibility of Polyvinyl Chloride (PVC) Medical Devices and Other Polymeric Materials with Reactive Ion Etching (RIE) and Inductively Couple Plasma (ICP) Sterilization Using a Quality by Design (QbD) Approach by de Oliveira, Débora Cristina, Calixto, Leandro Augusto, Fukuda, Isa Martins, Saviano, Alessandro Morais, Moreira, Adir José, Kawano, Yoshio, Mansano, Ronaldo Domingues, de Jesus Andreoli Pinto, Terezinha, Lourenço, Felipe Rebello

“…Purpose The sterilization process for medical devices is an important step due to microbiological quality requirements of polymeric products. Irradiation and…”
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