Search Results - "Savić, Marina"
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Synthesis and anticancer potential of novel 5,6-oxygenated and/or halogenated steroidal d-homo lactones
Published in Bioorganic & medicinal chemistry (15-01-2021)“…[Display omitted] •New steroidal lactones with modifications in positions C5 and C6 were synthesized.•Compounds were tested on six tumor cell lines for their…”
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Novel D-modified heterocyclic androstane derivatives as potential anticancer agents: Synthesis, characterization, in vitro and in silico studies
Published in The Journal of steroid biochemistry and molecular biology (01-10-2023)“…Cancer remains a major health concern worldwide. The most frequently diagnosed types of cancer are caused by abnormal production or action of steroid hormones…”
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Abiraterone and Galeterone, Powerful Tools Against Prostate Cancer: Present and Perspective
Published in Pharmaceutics (30-10-2024)“…Due to the high prostate cancer incidence worldwide, the development of different methods of treatment continues to be a hot research topic. Since its first…”
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Modified bile acids and androstanes—Novel promising inhibitors of human cytochrome P450 17A1
Published in The Journal of steroid biochemistry and molecular biology (01-01-2021)“…•Modified bile acids and androstane derivatives binds with high affinity by human CYP17A1.•Novel ligands decrease rate of hydroxylation of progesterone –…”
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Evaluation of A-ring fused pyridine d-modified androstane derivatives for antiproliferative and aldo-keto reductase 1C3 inhibitory activity
Published in MedChemComm (01-06-2018)“…New A-ring pyridine fused androstanes in 17a-homo-17-oxa (d-homo lactone), 17α-picolyl or 17( )-picolinylidene series were synthesized and validated by X-ray…”
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Pumpkin seed oil cake/polyethylene film as new food packaging material, with perspective for packing under modified atmosphere
Published in Packaging technology & science (01-01-2021)“…Biopolymer packaging materials show increasing perspective in food packaging. Main limitation remains their high water sensitivity and poor water vapour…”
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Attitudes regarding the national forensic DNA database: Survey data from the general public, prison inmates and prosecutors’ offices in the Republic of Serbia
Published in Forensic science international : genetics (01-05-2017)“…Highlights • The first Eastern European survey of public views on forensic DNA use is conducted. • Professionals linked to forensic genetics show permissive…”
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The analysis of chromatographic behavior of homoandrostane derivatives in reversed-phase ultra-high performance liquid chromatography
Published in Acta Periodica Technologica (01-01-2021)“…Homoandrostane derivatives, as compounds with significant bioactivity, were studied in terms of their chromatographic behavior in reversed-phase ultra-high…”
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Microwave assisted synthesis and biomedical potency of salicyloyloxy and 2-methoxybenzoyloxy androstane and stigmastane derivatives
Published in Steroids (01-02-2015)“…[Display omitted] •New steroidal salicyloyl esters were synthesized by MW and conventional methods.•Antioxidant and cytotoxic activity of new compounds was…”
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Structural diversity of bioactive steroid compounds isolated from soft corals in the period 2015–2020
Published in The Journal of steroid biochemistry and molecular biology (01-04-2022)“…[Display omitted] •Marine soft corals are good source of biologically active compounds.•Structures of steroids from soft corals are used in drug…”
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Steroid and Triterpenoid Compounds with Antiparasitic Properties
Published in Current topics in medicinal chemistry (01-01-2023)“…Parasitic diseases affect millions of people and animals, predominantly in the tropics, including visitors to tropical countries and other areas. Efficient and…”
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In silico ADMET analysis of the A-, B- and D-modified androstane derivatives with potential anticancer effects
Published in Steroids (01-01-2023)“…[Display omitted] •In silico ADMET properties were assessed for 28 steroid compounds.•Compound 24 is characterized as a leadlike, possessing druglike…”
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Estimation of chromatographic lipophilicity of some D-homo androstene derivatives
Published in Acta Periodica Technologica (01-01-2015)“…Quantitative structure-retention relationship (QSRR) method was applied to study the chromatographic behaviour of D-homo-androstene derivatives 1-7. Retention…”
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Development of new steroid-based hydrazide and (thio)semicarbazone compounds with anticancer properties
Published in The Journal of steroid biochemistry and molecular biology (01-09-2024)“…Most breast and prostate cancers are caused by abnormal production or action of steroidal hormones. Hormonal drugs based on steroid scaffolds represent a…”
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Hormone receptor binding, selectivity and cytotoxicity of steroid D-homo lactone loaded chitosan nanoparticles for the treatment of breast and prostate cancer cells
Published in Colloids and surfaces, B, Biointerfaces (01-08-2022)“…Chemically modified steroids have a long history as anti-neoplastic drugs. Incorporation of a lactone moiety in the steroid nucleus, as in previously obtained…”
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Quality assurance of the Serbian national E-PRTR register reported data for large combustion plants
Published in Hemijska industrija (01-01-2012)“…The Serbian E-PRTR register (The European Pollutant Release and Transfer Register) was established in 2007 and harmonized with PRTR protocol of Arhus…”
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Chemometrics of anisotropic lipophilicity of anticancer androstane derivatives determined by reversed-phase ultra high performance liquid chromatography with polar aprotic and protic modifiers
Published in Journal of Chromatography A (21-06-2022)“…•RP-UHPLC analysis was done to define chromatographic lipophilicity of androstane derivatives.•Two ULR and ten MLR QSRR models were defined.•Comparison of…”
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New A-homo lactam D-homo lactone androstane derivative: Synthesis and evaluation of cytotoxic and anti-inflammatory activities in vitro
Published in Steroids (01-05-2020)“…[Display omitted] •New A-homo lactam D-homo lactone androstane derivative was synthesized.•Strong cytotoxic and anti-inflammatory activities were…”
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Synthesis and antiproliferative activity of some A- and B modified D-homo lactone androstane derivatives
Published in Acta Periodica Technologica (01-01-2013)“…An efficient synthesis of several A- and B-modified D-homo lactone androstane derivatives from 3β-hydroxy-17-oxa-D-homoandrost-5-en-16-one (1) is reported…”
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New oxygen-containing androstane derivatives: Synthesis and biological potential
Published in Journal of chemical sciences (Bangalore, India) (01-12-2020)“…New steroidal D-homo androstane derivatives with 5β,6β-epoxy-3,16-dicarbonyl, 6α- and 6β-hydroxy-3,16-dicarbonyl and 3β,5α-dihydroxy-6,16-dicarbonyl moieties…”
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