Search Results - "Savery, Dawn"

Mechanical loading of cranial joints minimizes the craniofacial phenotype in Crouzon syndrome by Moazen, Mehran, Hejazi, Mahbubeh, Savery, Dawn, Jones, Dominic, Marghoub, Arsalan, Alazmani, Ali, Pauws, Erwin

“…Children with syndromic forms of craniosynostosis undergo a plethora of surgical interventions to resolve the clinical features caused by the premature fusion…”
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Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice by Pai, Yun Jin, Leung, Kit-Yi, Savery, Dawn, Hutchin, Tim, Prunty, Helen, Heales, Simon, Brosnan, Margaret E., Brosnan, John T., Copp, Andrew J., Greene, Nicholas D.E.

“…Glycine decarboxylase (GLDC) acts in the glycine cleavage system to decarboxylate glycine and transfer a one-carbon unit into folate one-carbon metabolism…”
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Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure by Leung, Kit-Yi, Pai, Yun Jin, Chen, Qiuying, Santos, Chloe, Calvani, Enrica, Sudiwala, Sonia, Savery, Dawn, Ralser, Markus, Gross, Steven S., Copp, Andrew J., Greene, Nicholas D.E.

“…Abnormal folate one-carbon metabolism (FOCM) is implicated in neural tube defects (NTDs), severe malformations of the nervous system. MTHFR mediates…”
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Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure by Escuin, Sarah, Vernay, Bertrand, Savery, Dawn, Gurniak, Christine B, Witke, Walter, Greene, Nicholas D E, Copp, Andrew J

“…The cytoskeleton is widely considered essential for neurulation, yet the mouse spinal neural tube can close despite genetic and non-genetic disruption of the…”
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Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure by Ybot-Gonzalez, Patricia, Savery, Dawn, Gerrelli, Dianne, Signore, Massimo, Mitchell, Claire E, Faux, Clare H, Greene, Nicholas D E, Copp, Andrew J

“…Planar-cell-polarity (PCP) signalling is necessary for initiation of neural tube closure in higher vertebrates. In mice with PCP gene mutations, a broad…”
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Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos by Galea, Gabriel L, Nychyk, Oleksandr, Mole, Matteo A, Moulding, Dale, Savery, Dawn, Nikolopoulou, Evanthia, Henderson, Deborah J, Greene, Nicholas D E, Copp, Andrew J

“…Human mutations in the planar cell polarity component VANGL2 are associated with the neural tube defect spina bifida. Homozygous Vangl2 mutation in mice…”
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Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse by Escuin, Sarah, Raza-Knight, Saba Rose, Savery, Dawn, Gaston-Massuet, Carles, Galea, Gabriel L, Greene, Nicholas D E, Copp, Andrew J

“…Understanding the molecular mechanisms that lead to birth defects is an important step towards improved primary prevention. Mouse embryos homozygous for the…”
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Vangl2-environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension by Nychyk, Oleksandr, Galea, Gabriel L, Molè, Matteo, Savery, Dawn, Greene, Nicholas D E, Stanier, Philip, Copp, Andrew J

“…Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished convergent extension (CE) cell movements leading to…”
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Novel mouse model of encephalocele: post-neurulation origin and relationship to open neural tube defects by Rolo, Ana, Galea, Gabriel L, Savery, Dawn, Greene, Nicholas D E, Copp, Andrew J

“…Encephalocele is a clinically important birth defect that can lead to severe disability in childhood and beyond. The embryonic and early fetal pathogenesis of…”
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Cellular mechanisms underlying Pax3- related neural tube defects and their prevention by folic acid by Sudiwala, Sonia, Palmer, Alexandra, Massa, Valentina, Burns, Alan J, Dunlevy, Louisa P E, de Castro, Sandra C P, Savery, Dawn, Leung, Kit-Yi, Copp, Andrew J, Greene, Nicholas D E

“…Neural tube defects (NTDs), including spina bifida and anencephaly, are among the most common birth defects worldwide, but their underlying genetic and…”
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Regulation of cell protrusions by small GTPases during fusion of the neural folds by Rolo, Ana, Savery, Dawn, Escuin, Sarah, de Castro, Sandra C, Armer, Hannah E J, Munro, Peter M G, Molè, Matteo A, Greene, Nicholas D E, Copp, Andrew J

“…Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of…”
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Apoptosis is not required for mammalian neural tube closure by Massa, Valentina, Savery, Dawn, Ybot-Gonzalez, Patricia, Ferraro, Elisabetta, Rongvaux, Anthony, Cecconi, Francesco, Flavell, Richard, Greene, Nicholas D.E, Copp, Andrew J

“…Apoptotic cell death occurs in many tissues during embryonic development and appears to be essential for processes including digit formation and cardiac…”
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Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non‐ketotic hyperglycinemia by Leung, Kit‐Yi, De Castro, Sandra C. P., Santos, Chloe, Savery, Dawn, Prunty, Helen, Gold‐Diaz, Diana, Bennett, Stuart, Heales, Simon, Copp, Andrew J., Greene, Nicholas D. E.

“…Glycine abundance is modulated in a tissue‐specific manner by use in biosynthetic reactions, catabolism by the glycine cleavage system (GCS), and excretion via…”
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The non-canonical Wnt-PCP pathway shapes the caudal neural plate by López-Escobar, Beatriz, Caro-Vega, José Manuel, Vijayraghavan, Deepthi S., Plageman, Timothy F., Sanchez-Alcazar, José A., Moreno, Roberto Carlos, Savery, Dawn, Márquez-Rivas, Javier, Davidson, Lance A., Ybot-González, Patricia

“…The last stage of neural tube (NT) formation involves closure of the caudal neural plate (NP), an embryonic structure formed by neuromesodermal progenitors and…”
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In amnio MRI of mouse embryos by Roberts, Thomas A, Norris, Francesca C, Carnaghan, Helen, Savery, Dawn, Wells, Jack A, Siow, Bernard, Scambler, Peter J, Pierro, Agostino, De Coppi, Paolo, Eaton, Simon, Lythgoe, Mark F

“…Mouse embryo imaging is conventionally carried out on ex vivo embryos excised from the amniotic sac, omitting vital structures and abnormalities external to…”
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Evidence of functional redundancy between MID proteins: implications for the presentation of Opitz syndrome by Granata, Alessandra, Savery, Dawn, Hazan, Jamile, Cheung, Billy M.F., Lumsden, Andrew, Quaderi, Nandita A.

“…Opitz G/BBB syndrome (OS) is a congenital defect characterized by hypertelorism and hypospadias, but additional midline malformations are also common in OS…”
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Biomechanical coupling facilitates spinal neural tube closure in mouse embryos by Galea, Gabriel L., Cho, Young-June, Galea, Gauden, Molè, Matteo A., Rolo, Ana, Savery, Dawn, Moulding, Dale, Culshaw, Lucy H., Nikolopoulou, Evanthia, Greene, Nicholas D. E., Copp, Andrew J.

“…Neural tube (NT) formation in the spinal region of the mammalian embryo involves a wave of “zippering” that passes down the elongating spinal axis, uniting the…”
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Genetic interaction of Pax3 mutation and canonical Wnt signaling modulates neural tube defects and neural crest abnormalities by Palmer, Alexandra J., Savery, Dawn, Massa, Valentina, Copp, Andrew J., Greene, Nicholas D. E.

“…Summary Mouse models provide opportunities to investigate genetic interactions that cause or modify the frequency of neural tube defects (NTDs). Mutation of…”
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Integrin-Mediated Focal Anchorage Drives Epithelial Zippering during Mouse Neural Tube Closure by Molè, Matteo A., Galea, Gabriel L., Rolo, Ana, Weberling, Antonia, Nychyk, Oleksandr, De Castro, Sandra C., Savery, Dawn, Fässler, Reinhard, Ybot-González, Patricia, Greene, Nicholas D.E., Copp, Andrew J.

“…Epithelial fusion is a key process of morphogenesis by which tissue connectivity is established between adjacent epithelial sheets. A striking and poorly…”
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Association of embryonic inositol status with susceptibility to neural tube defects, metabolite profile, and maternal inositol intake by Leung, Kit‐Yi, Weston, Eleanor, De Castro, Sandra C. P., Nikolopoulou, Evanthia, Sudiwala, Sonia, Savery, Dawn, Eaton, Simon, Copp, Andrew J., Greene, Nicholas D. E.

“…Maternal nutrition contributes to gene–environment interactions that influence susceptibility to common congenital anomalies such as neural tube defects…”
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