Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease

Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease

The effects of lifestyle modifications in nonalcoholic fatty liver disease (NAFLD) are incompletely defined. We aimed at determining the association of changes in body weight and lifestyle with changes in serum ALT levels. We analyzed annual health checkup data from 1546 employees. Of 469 subjects w...

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Bibliographic Details
Published in:Journal of hepatology Vol. 43; no. 6; pp. 1060 - 1066
Main Authors: Suzuki, Ayako, Lindor, Keith, Saver, Jenny St, Lymp, James, Mendes, Flavia, Muto, Ayako, Okada, Toshihide, Angulo, Paul
Format: Journal Article
Language:English
Published: Oxford Elsevier B.V 01-12-2005
Elsevier
Subjects:
Adult
Alanine Transaminase - blood
Alcohol Drinking - adverse effects
Aminotransferases
Biological and medical sciences
Biomarkers - blood
Body Weight
Body weight Lifestyle
Exercise
Fatty Liver - blood
Fatty Liver - therapy
Gastroenterology. Liver. Pancreas. Abdomen
Health Behavior
Humans
Insulin resistance
Life Style
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Longitudinal Studies
Male
Medical sciences
Middle Aged
Nonalcoholic fatty liver disease
Other diseases. Semiology
Risk Reduction Behavior
Smoking
Weight Loss
Insulin resistance
Nonalcoholic fatty liver disease
Aminotransferases
Body weight Lifestyle
Resistance
Body weight
Non alcoholic steatohepatitis
Gastroenterology
Digestive diseases
Hepatic disease
Insulin
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Summary:The effects of lifestyle modifications in nonalcoholic fatty liver disease (NAFLD) are incompletely defined. We aimed at determining the association of changes in body weight and lifestyle with changes in serum ALT levels. We analyzed annual health checkup data from 1546 employees. Of 469 subjects with elevated ALT, we selected 348 male subjects by excluding those who had other causes of liver disease. They were followed for one year to assess the association of change in lifestyle with change in serum ALT. The 136 subjects who had ALT normalization were followed for two years to assess the association between lifestyle management and persistently normal ALT. In adjusted analysis, weight loss and regular exercise were significantly associated with improvement in serum ALT and increased the odds of ALT normalization, while starting smoking was significantly associated with deterioration in serum ALT. Subjects achieving ≥5% weight reduction showed improvement in serum ALT. Reduction in alcohol consumption was not associated with changes in serum ALT. Maintaining reduced weight (<5% gain) was significantly associated with persistently normal ALT. Reducing weight by at least 5% with subsequent weight control and exercising regularly may be beneficial in treating NAFLD.
Bibliography:ObjectType-Article-1
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ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2005.06.008