Search Results - "Saven, A"

Extended Rituximab (anti-CD20 monoclonal antibody) therapy for relapsed or refractory low-grade or follicular non-Hodgkin's lymphoma by Piro, L. D., White, C. A., Grillo-López, A. J., Janakiraman, N., Saven, A., Beck, T. M., Varns, C., Shuey, S., Czuczman, M., Lynch, J. W., Kolit, J. E., Jain, V.

“…Background: Rituximab is a chimeric monoclonal antibody directed against the B-cell CD20 antigen which has been utilized for therapy of B-cell non-Hodgkin's…”
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The Scripps Clinic experience with cladribine (2-CdA) in the treatment of chronic lymphocytic leukemia by Saven, A

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2-Chlorodeoxyadenosine treatment of low-grade lymphomas by Kay, A C, Saven, A, Carrera, C J, Carson, D A, Thurston, D, Beutler, E, Piro, L D

“…Because of the need to identify effective new agents in the treatment of non-Hodgkin's lymphoma and because of the high activity of the purine analog…”
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Enzyme Replacement Therapy for Gaucher Disease by Beutler, E., Kay, A., Saven, A., Garver, P., Thurston, D., Dawson, A., Rosenbloom, B.

“…Four patients with moderately severe type I Gaucher disease were treated with commercially available mannose terminated glucocerebrosidase (Ceredase; Genzyme,…”
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Cladribine and mitoxantrone dose escalation in indolent non-Hodgkin's lymphoma by Saven, A, Lee, T, Kosty, M, Piro, L

“…Since cladribine (2-chlorodeoxyadenosine [2-CdA]) and mitoxantrone both exhibit major activity against indolent lymphoid malignancies and have different…”
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Outpatient high-dose chemotherapy with autologous stem-cell rescue for hematologic and nonhematologic malignancies by Meisenberg, B R, Miller, W E, McMillan, R, Callaghan, M, Sloan, C, Brehm, T, Kosty, M P, Kroener, J, Longmire, R, Saven, A, Piro, L D

“…A prospective study to determine the feasibility of high-dose chemotherapy (HDC) and autologous stem-cell rescue (ASCR) in the outpatient setting. One hundred…”
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Relationship of Deoxycytidine Kinase and Cytoplasmic 5’-Nucleotidase to the Chemotherapeutic Efficacy of 2-Chlorodeoxyadenosine by Kawasaki, Hajime, Carrera, Carlos J., Piro, Lawrence D., Saven, Alan, Kipps, Thomas J., Carson, Dennis A.

“…The agent 2-chlorodeoxyadenosine (2-CdA) has chemotherapeutic activity in hairy cell leukemia (HCL) and in refractory chronic lymphocytic leukemia (CLL). The…”
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2-Chlorodeoxyadenosine activity in patients with untreated chronic lymphocytic leukemia by Saven, A, Lemon, R H, Kosty, M, Beutler, E, Piro, L D

“…2-chlorodeoxyadenosine (2-CdA; cladribine) is a purine analog with activity in patients with chronic lymphocytic leukemia (CLL) who fail to respond to…”
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Diagnostic Application of Two-Color Flow Cytometry in 161 Cases of Hairy Cell Leukemia by Robbins, Bruce A., Ellison, Douglas J., Spinosa, John C., Carey, Cristin A., Lukes, Robert J., Poppema, Sibrand, Saven, Alan, Piro, Lawrence D.

“…Recent immunophenotypic studies of hairy cell leukemia (HCL) have suggested specific patterns of immunoreactiv-ity that may aid in diagnosis. We studied…”
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An Open-label Pilot Trial of Cladibrine (2-Chlorodeoxyadenosine) in Patients with Primary Sclerosing Cholangitis by Duchini, A, Younossi, Z M, Saven, A, Bordin, G M, Knowles, H J, Pockros, P J

“…Cladribine (2-chlorodeoxyadenosine) is a nucleoside analog with specific antilymphocytic activity that has been used in patients with a variety of lymphoid…”
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Comparative efficacy of the newer nucleosides (fludarabine, 2'-deoxycoformycin, and 2-chlorodeoxyadenosine) in the treatment of indolent lymphoid malignancies by Saven, A

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Fludarabine treatment and transfusion-associated graft-versus-host disease by Saven, A

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Major activity of cladribine in patients with de novo B-cell prolymphocytic leukemia by Saven, A, Lee, T, Schlutz, M, Jacobs, A, Ellison, D, Longmire, R, Piro, L

“…De novo B-cell prolymphocytic leukemia (B-PLL) is a distinct clinicopathologic entity usually characterized by marked lymphocytosis, massive splenomegaly, an…”
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Activated integrin alpha v beta 3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells by Rolli, M, Fransvea, E, Pilch, J, Saven, A, Felding-Habermann, B

“…Expression of adhesion receptor integrin alpha v beta 3 in an activated functional form strongly promotes metastasis in human breast cancer cells. Here, we…”
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Treatment of Hairy Cell Leukemia by Saven, Alan, Piro, Lawrence D.

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Immunomorphologic analysis of bone marrow biopsies after treatment with 2-chlorodeoxyadenosine for hairy cell leukemia by ELLISON, D. J, SHARPE, R. W, ROBBINS, B. A, SPINOSA, J. C, LEOPARD, J. D, SAVEN, A, PIRO, L. D

“…Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA) induces complete remissions in 85% of patients. Complete remission has been defined as the…”
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2-Chlorodeoxyadenosine: a potent antimetabolite with major activity in the treatment of indolent lymphoproliferative disorders by Saven, A, Piro, L D

“…2-Chlorodeoxyadenosine (2-CdA) is unique compared with traditional antimetabolites in that it is equally active against dividing and resting lymphocytes, which…”
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The Scripps Clinic experience with 2-chlorodeoxyadenosine in the treatment of hairy cell leukemia by Piro, L D, Ellison, D J, Saven, A

“…Follow-up data is now available on 144 patients with hairy cell leukemia treated with 2-chlorodeoxyadenosine (2-CdA) at the Scripps Clinic. Of 144 patients…”
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Pharmacokinetic study of oral and bolus intravenous 2-chlorodeoxyadenosine in patients with malignancy by Saven, A, Cheung, W K, Smith, I, Moyer, M, Johannsen, T, Rose, E, Gollard, R, Kosty, M, Miller, W E, Piro, L D

“…This study was designed to evaluate the absolute bioavailability (F value) of 2-chlorodeoxyadenosine (cladribine; 2-CdA) after multiple oral administrations,…”
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Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia by Nieva, Jorge, Bethel, Kelly, Saven, Alan

“…Hairy cell leukemia (HCL) is an indolent B-cell neoplasm, strongly expressing CD20. Despite initial very high response rates following cladribine, many…”
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