Search Results - "Savaskan, N"

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner by Chen, D, Fan, Z, Rauh, M, Buchfelder, M, Eyupoglu, I Y, Savaskan, N

“…Activating transcription factor 4 (ATF4) is a critical mediator of metabolic and oxidative homeostasis and cell survival. ATF4 is elevated in response to…”
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Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis by Fan, Z, Wirth, A-K, Chen, D, Wruck, C J, Rauh, M, Buchfelder, M, Savaskan, N

“…Cancer cells are hallmarked by high proliferation and imbalanced redox consumption and signaling. Various oncogenic pathways such as proliferation and evading…”
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Correction: Dissection of mitogenic and neurodegenerative actions of cystine and glutamate in malignant gliomas by Savaskan, N. E., Seufert, S., Hauke, J., Tränkle, C., Eyüpoglu, I. Y., Hahnen, E.

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MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis by Ghoochani, A, Schwarz, M A, Yakubov, E, Engelhorn, T, Doerfler, A, Buchfelder, M, Bucala, R, Savaskan, N E, Eyüpoglu, I Y

“…Microglial cells in the brain tumor microenvironment are associated with enhanced glioma malignancy. They persist in an immunosuppressive M2 state at the…”
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Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP) by Horn, A., Krist, L., Lieb, W., Montellano, F. A., Kohls, M., Haas, K., Gelbrich, G., Bolay-Gehrig, S. J., Morbach, C., Reese, J. P., Störk, S., Fricke, J., Zoller, T., Schmidt, S., Triller, P., Kretzler, L., Rönnefarth, M., Von Kalle, C., Willich, S. N., Kurth, F., Steinbeis, F., Witzenrath, M., Bahmer, T., Hermes, A., Krawczak, M., Reinke, L., Maetzler, C., Franzenburg, J., Enderle, J., Flinspach, A., Vehreschild, J., Schons, M., Illig, T., Anton, G., Ungethüm, K., Finkenberg, B. C., Gehrig, M. T., Savaskan, N., Heuschmann, P. U., Keil, T., Schreiber, S.

“…Purpose Over the course of COVID-19 pandemic, evidence has accumulated that SARS-CoV-2 infections may affect multiple organs and have serious clinical…”
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Dissection of mitogenic and neurodegenerative actions of cystine and glutamate in malignant gliomas by Savaskan, N E, Seufert, S, Hauke, J, Tränkle, C, Eyüpoglu, I Y, Hahnen, E

“…Malignant glioma represents one of the most aggressive and lethal human neoplasias. A hallmark of gliomas is their rapid proliferation and destruction of vital…”
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Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma by Savaskan, N E, Rocha, L, Kotter, M R, Baer, A, Lubec, G, van Meeteren, L A, Kishi, Y, Aoki, J, Moolenaar, W H, Nitsch, R, Bräuer, A U

“…Autotaxin is a secreted cell motility-stimulating exo-phosphodiesterase with lysophospholipase D activity that generates bioactive lysophosphatidic acid…”
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Myelination in the hippocampus during development and following lesion by Meier, S, Bräuer, A U, Heimrich, B, Nitsch, R, Savaskan, N E

“…Myelin is crucial for the stabilization of axonal projections in the developing and adult mammalian brain. However, myelin components also act as a…”
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A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting by Nitsch, Robert, Bräuer, Anja U, Savaskan, Nicolai E, Kühn, Hartmut, Prehn, Siegfried, Ninnemann, Olaf

“…Outgrowth of axons in the central nervous system is governed by specific molecular cues. Molecules detected so far act as ligands that bind to specific…”
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Molecular and functional analysis of hyperpolarization‐activated pacemaker channels in the hippocampus after entorhinal cortex lesion by BrÄUer, Anja U., Savaskan, Nicolai E., Kole, Maarten H. P., Plaschke, Martina, Monteggia, Lisa M., Nestler, Eric J., SimbÜRger, Eva, Deisz, Rudolf A., Ninnemann, Olaf, Nitsch, Robert

“…ABSTRACT Differential display of hippocampal tissue after entorhinal cortex lesion (ECL) revealed decreases in mRNA encoding the neuronal…”
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Selenium and brain function: a poorly recognized liaison by Schweizer, Ulrich, Bräuer, Anja U, Köhrle, Josef, Nitsch, Robert, Savaskan, Nicolai E

“…Molecular biology has recently contributed significantly to the recognition of selenium (Se) 2 2 Most Se is contained in proteins as selenocysteine (in meat)…”
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Molecules involved in reactive sprouting in the hippocampus by Savaskan, N E, Nitsch, R

“…Denervation of the hippocampus triggers reactive responses in neurons and glial cells in their affected strata in a temporally ordered fashion. Many of these…”
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Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion by Schäfer, Michael, Bräuer, Anja U., Savaskan, Nicolai E., Rathjen, Fritz G., Brümmendorf, Thomas

“…The IgLON subgroup of the immunoglobulin superfamily consists of four members that are thought to be important in neural cell–cell recognition. Here, we cloned…”
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Cholecystokinin expression after hippocampal deafferentiation: molecular evidence revealed by differential display-reverse transcription–polymerase chain reaction by Bräuer, A.U, Savaskan, N.E, Plaschke, M, Ninnemann, O, Nitsch, R

“…The cortical information flow via the perforant path represents a major excitatory projection to the hippocampus. Lesioning this projection leads to massive…”
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Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family by Savaskan, Nicolai E., Bräuer, Anja U., Nitsch, Robert

“…Phospholipid‐mediated signalling on neurons provokes diverse responses such as neurogenesis, pattern formation and neurite remodelling. We have recently…”
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Regulation of expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Tissue-specific expression pattern and identification of functional cis- and trans-regulatory elements by Borchert, Astrid, Savaskan, Nicolai E, Kuhn, Hartmut

“…A sperm nucleus glutathione peroxidase (snGPx), which is closely related to the phospholipid hydroperoxide glutathione peroxidase (phGPx), was recently…”
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Perforant path lesion induces up-regulation of stathmin messenger RNA, but not SCG10 messenger RNA, in the adult rat hippocampus by Bräuer, A.U., Savaskan, N.E., Plaschke, M., Ninnemann, O., Nitsch, R.

“…In this study, we performed in situ hybridization analysis of the expression pattern of two growth-associated proteins, stathmin and SCG10, in the hippocampus…”
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A Role for the Eph Ligand Ephrin-A3 in Entorhino-Hippocampal Axon Targeting by Stein, Eckart, Savaskan, Nicolai E, Ninnemann, Olaf, Nitsch, Robert, Zhou, Renping, Skutella, Thomas

“…Neurons of layers II and III of the entorhinal cortex constitute the major afferent connection of the hippocampus. The molecular mechanisms that target the…”
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IG-molecule Kilon shows differential expression pattern from LAMP in the developing and adult rat hippocampus by Bräuer, A.U., Savaskan, N.E., Plaschke, M., Prehn, S., Ninnemann, O., Nitsch, R.

“…Cell recognition molecules of the immunoglobulin superfamily are involved in the formation, establishment, and plasticity of neural circuits in the central…”
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Sema3C and Netrin-1 Differentially Affect Axon Growth in the Hippocampal Formation by Steup, Andreas, Lohrum, Marion, Hamscho, Nadja, Savaskan, Nicolai E., Ninnemann, Olaf, Nitsch, Robert, Fujisawa, Hajime, Püschel, Andreas W., Skutella, Thomas

“…The interaction between outgrowing neurons and their targets is a central element in the development of the afferent and efferent connections of the…”
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