Search Results - "Savas, Jeffrey N."

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor by Parkhurst, Christopher N., Yang, Guang, Ninan, Ipe, Savas, Jeffrey N., Yates, John R., Lafaille, Juan J., Hempstead, Barbara L., Littman, Dan R., Gan, Wen-Biao

“…Microglia are the resident macrophages of the CNS, and their functions have been extensively studied in various brain pathologies. The physiological roles of…”
Get full text

Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures by Toyama, Brandon H., Savas, Jeffrey N., Park, Sung Kyu, Harris, Michael S., Ingolia, Nicholas T., Yates, John R., Hetzer, Martin W.

“…Intracellular proteins with long lifespans have recently been linked to age-dependent defects, ranging from decreased fertility to the functional decline of…”
Get full text

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease by Burbulla, Lena F., Song, Pingping, Mazzulli, Joseph R., Zampese, Enrico, Wong, Yvette C., Jeon, Sohee, Santos, David P., Blanz, Judith, Obermaier, Carolin D., Strojny, Chelsee, Savas, Jeffrey N., Kiskinis, Evangelos, Zhuang, Xiaoxi, Krüger, Rejko, Surmeier, D. James, Krainc, Dimitri

“…Mitochondrial and lysosomal dysfunction have been implicated in substantia nigra dopaminergic neurodegeneration in Parkinson’s disease (PD), but how these…”
Get full text

FLRT Proteins Are Endogenous Latrophilin Ligands and Regulate Excitatory Synapse Development by O'Sullivan, Matthew L., de Wit, Joris, Savas, Jeffrey N., Comoletti, Davide, Otto-Hitt, Stefanie, Yates, John R., Ghosh, Anirvan

“…Latrophilins (LPHNs) are a small family of G protein-coupled receptors known to mediate the massive synaptic exocytosis caused by the black widow spider venom…”
Get full text

Unbiased Discovery of Glypican as a Receptor for LRRTM4 in Regulating Excitatory Synapse Development by de Wit, Joris, O’Sullivan, Matthew L., Savas, Jeffrey N., Condomitti, Giuseppe, Caccese, Max C., Vennekens, Kristel M., Yates, John R., Ghosh, Anirvan

“…Leucine-rich repeat (LRR) proteins have recently been identified as important regulators of synapse development and function, but for many LRR proteins the…”
Get full text

Using stable isotope labeling to advance our understanding of Alzheimer’s disease etiology and pathology by Hark, Timothy J., Savas, Jeffrey N.

“…Stable isotope labeling with mass spectrometry (MS)‐based proteomic analysis has become a powerful strategy to assess protein steady‐state levels, protein…”
Get full text

Derailed protein turnover in the aging mammalian brain by Rao, Nalini R, Upadhyay, Arun, Savas, Jeffrey N

“…Efficient protein turnover is essential for cellular homeostasis and organ function. Loss of proteostasis is a hallmark of aging culminating in severe…”
Get full text

Spatial neurolipidomics—MALDI mass spectrometry imaging of lipids in brain pathologies by Jha, Durga, Blennow, Kaj, Zetterberg, Henrik, Savas, Jeffrey N., Hanrieder, Jörg

“…Given the complexity of nervous tissues, understanding neurochemical pathophysiology puts high demands on bioanalytical techniques with respect to specificity…”
Get full text

Extremely Long-Lived Nuclear Pore Proteins in the Rat Brain by Savas, Jeffrey N., Toyama, Brandon H., Xu, Tao, Yates, John R., Hetzer, Martin W.

“…To combat the functional decline of the proteome, cells use the process of protein turnover to replace potentially impaired polypeptides with new functional…”
Get full text

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway by Jeong, Hyunkyung, Cohen, Dena E, Cui, Libin, Supinski, Andrea, Savas, Jeffrey N, Mazzulli, Joseph R, Yates, John R, Bordone, Laura, Guarente, Leonard, Krainc, Dimitri

“…Huntington's disease is a neurodegenerative disease caused by the accumulation of mutant HTT protein. Now, two groups led by Dimitri Krainc and Wenzhen Duan…”
Get full text

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E) by Park, Joonhee, Yang, Jingyi, Wenzel, Alexander T., Ramachandran, Akshaya, Lee, Wung J., Daniels, Jay C., Kim, Juhyun, Martinez-Escala, Estela, Amankulor, Nduka, Pro, Barbara, Guitart, Joan, Mendillo, Marc L., Savas, Jeffrey N., Boggon, Titus J., Choi, Jaehyuk

“…Cutaneous T-cell lymphoma (CTCL) is an incurable non-Hodgkin lymphoma of the skin-homing T cell. In early-stage disease, lesions are limited to the skin, but…”
Get full text

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy by Wang, Lu, Zhao, Zibo, Ozark, Patrick A., Fantini, Damiano, Marshall, Stacy A., Rendleman, Emily J., Cozzolino, Kira A., Louis, Nundia, He, Xingyao, Morgan, Marc A., Takahashi, Yoh-hei, Collings, Clayton K., Smith, Edwin R., Ntziachristos, Panagiotis, Savas, Jeffrey N., Zou, Lihua, Hashizume, Rintaro, Meeks, Joshua J., Shilatifard, Ali

“…The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene…”
Get full text

Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase by Jha, Sujata, Rollins, Madeline G., Fuchs, Gabriele, Procter, Dean J., Hall, Elizabeth A., Cozzolino, Kira, Sarnow, Peter, Savas, Jeffrey N., Walsh, Derek

“…The poxvirus vaccinia virus phosphorylates serine/threonine residues in the human small ribosomal subunit RACK1, converting it to a plant-like state to favour…”
Get full text

An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses by Condomitti, Giuseppe, Wierda, Keimpe D., Schroeder, Anna, Rubio, Sara E., Vennekens, Kristel M., Orlandi, Cesare, Martemyanov, Kirill A., Gounko, Natalia V., Savas, Jeffrey N., de Wit, Joris

“…Pyramidal neuron dendrites integrate synaptic input from multiple partners. Different inputs converging on the same dendrite have distinct structural and…”
Get full text

Synapse biology in the ‘circuit-age’—paths toward molecular connectomics by Schreiner, Dietmar, Savas, Jeffrey N, Herzog, Etienne, Brose, Nils, de Wit, Joris

“…Highlights • The CNS represents a precisely organized synaptic network formed by diverse neurons. • Neuronal adhesion proteins substantially contribute to…”
Get full text

Differences in AMPA and Kainate Receptor Interactomes Facilitate Identification of AMPA Receptor Auxiliary Subunit GSG1L by Shanks, Natalie F., Savas, Jeffrey N., Maruo, Tomohiko, Cais, Ondrej, Hirao, Atsushi, Oe, Souichi, Ghosh, Anirvan, Noda, Yasuko, Greger, Ingo H., Yates, John R., Nakagawa, Terunaga

“…AMPA receptor (AMPA-R) complexes consist of channel-forming subunits, GluA1-4, and auxiliary proteins, including TARPs, CNIHs, synDIG1, and CKAMP44, which can…”
Get full text

Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer by Apóstolo, Nuno, Smukowski, Samuel N., Vanderlinden, Jeroen, Condomitti, Giuseppe, Rybakin, Vasily, ten Bos, Jolijn, Trobiani, Laura, Portegies, Sybren, Vennekens, Kristel M., Gounko, Natalia V., Comoletti, Davide, Wierda, Keimpe D., Savas, Jeffrey N., de Wit, Joris

“…Excitatory and inhibitory neurons are connected into microcircuits that generate circuit output. Central in the hippocampal CA3 microcircuit is the mossy fiber…”
Get full text

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation by Jeong, Hyunkyung, Then, Florian, Melia, Thomas J., Mazzulli, Joseph R., Cui, Libin, Savas, Jeffrey N., Voisine, Cindy, Paganetti, Paolo, Tanese, Naoko, Hart, Anne C., Yamamoto, Ai, Krainc, Dimitri

“…Huntington's disease (HD) is an incurable neurodegenerative disease caused by neuronal accumulation of the mutant protein huntingtin. Improving clearance of…”
Get full text

Proteomic Analysis of Wild-type and Mutant Huntingtin-associated Proteins in Mouse Brains Identifies Unique Interactions and Involvement in Protein Synthesis by Culver, Brady P., Savas, Jeffrey N., Park, Sung K., Choi, Jeong H., Zheng, Shuqiu, Zeitlin, Scott O., Yates, John R., Tanese, Naoko

“…Huntington disease is a neurodegenerative disorder caused by a CAG repeat amplification in the gene huntingtin (HTT) that is reflected by a polyglutamine…”
Get full text

Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins by Elegheert, Jonathan, Cvetkovska, Vedrana, Clayton, Amber J., Heroven, Christina, Vennekens, Kristel M., Smukowski, Samuel N., Regan, Michael C., Jia, Wanyi, Smith, Alexandra C., Furukawa, Hiro, Savas, Jeffrey N., de Wit, Joris, Begbie, Jo, Craig, Ann Marie, Aricescu, A. Radu

“…Neuroligin-neurexin (NL-NRX) complexes are fundamental synaptic organizers in the central nervous system. An accurate spatial and temporal control of NL-NRX…”
Get full text