Search Results - "Savant, Ishani"

Exposure–Response Analyses of Polysomnography and Subjective Sleep Efficacy End Points From the Phase 3 Trials of Lemborexant, a Dual Orexin Receptor Antagonist for the Treatment of Insomnia by Lalovic, Bojan, Savant Landry, Ishani, Moline, Margaret, Reyderman, Larisa, Hussein, Ziad

“…This report describes polysomnography and sleep diary exposure–response analyses from Study E2006‐G000‐304 (Study 304), a 1‐month trial of 5‐ or 10‐mg…”
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Utilization of In Vitro, In Vivo and In Silico Tools to Evaluate the pH-Dependent Absorption of a BCS Class II Compound and Identify a pH-Effect Mitigating Strategy by Gesenberg, Christoph, Mathias, Neil R., Xu, Yan, Crison, John, Savant, Ishani, Saari, Amy, Good, David J., Hemenway, Jeffrey N., Narang, Ajit S., Schartman, Richard R., Zheng, Naiyu, Buzescu, Adela, Patel, Jatin

“…Purpose To describe a stepwise approach to evaluate the pH effect for a weakly basic drug by in vitro , in vivo and in silico techniques and identify a viable…”
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Effects of oral posaconazole on the pharmacokinetic properties of oral and intravenous midazolam: A phase I, randomized, open-label, crossover study in healthy volunteers by Krishna, Gopal, PhD, Moton, Allen, PharmD, Ma, Lei, MS, Savant, Ishani, PhD, Martinho, Monika, MS, Seiberling, Michael, MD, McLeod, James, MD

“…Abstract Background: Like itraconazole and ketoconazole, posaconazole, a broad-spectrum oral triazole antifungal, inhibits the activity of the cytochrome P450…”
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Pharmacokinetic interactions between BMS-626529, the active moiety of the HIV-1 attachment inhibitor prodrug BMS-663068, and ritonavir or ritonavir-boosted atazanavir in healthy subjects by Zhu, Li, Hruska, Matthew, Hwang, Carey, Shah, Vaishali, Furlong, Michael, Hanna, George J, Bertz, Richard, Landry, Ishani Savant

“…BMS-663068 is a prodrug of BMS-626529, a first-in-class attachment inhibitor that binds directly to HIV-1 gp120, preventing initial viral attachment and entry…”
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The effects of apremilast on the QTc interval in healthy male volunteers: a formal, thorough QT study by Palmisano, Maria, Wu, Anfan, Assaf, Mahmoud, Liu, Liangang, Park, C Hyung, Savant, Ishani, Liu, Yong, Zhou, Simon

“…This study was conducted to evaluate the effect of apremilast and its major metabolites on the placebocorrected change-from-baseline QTc interval of an…”
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PHASE 1 INVESTIGATION INTO THE SAFETY, TOLERABILITY, PHARMACOKINETICS (PK) AND PHARMACODYNAMICS (PD) OF E2027, A SELECTIVE PHOSPHODIESTERASE-9 (PDE9) INHIBITOR by Lai, Robert Y.K., Gordon, Robert, Chang, Min-Kun, Boyd, Peter, Savant-Landry, Ishani, Aluri, Jagadeesh, Ino, Mitsuhiro, Horie, Kanta, Kotani, Sadaharu, Schuck, Edgar L., Luthman, Johan

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A novel HPLC assay for pentamidine: comparative effects of creatinine and inulin on GFR estimation and pentamidine renal excretion in the isolated perfused rat kidney by Poola, Nagaraju R, Bhuiyan, Dider, Ortiz, Stephan, Savant, Ishani A, Sidhom, Madiha, Taft, David R, Kirschenbaum, Harold, Kalis, Michelle

“…1. To develop and validate an analytical method for pentamidine (PTM) by reversed-phase HPLC. 2. To compare the effects of creatinine and inulin on PTM…”
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Population Pharmacokinetics Analysis To Inform Efavirenz Dosing Recommendations in Pediatric HIV Patients Aged 3 Months to 3 Years by Luo, Man, Chapel, Sunny, Sevinsky, Heather, Savant, Ishani, Cirincione, Brenda, Bertz, Richard, Roy, Amit

“…Efavirenz (EFV) is a nonnucleoside reverse transcriptase inhibitor approved worldwide for the treatment of HIV in adults and children over 3 years of age or…”
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Bioanalysis of dried saliva spot (DSS) samples using detergent-assisted sample extraction with UHPLC-MS/MS detection by Zheng, Naiyu, Zeng, Jianing, Ji, Qin C., Angeles, Aida, Aubry, Anne-Francoise, Basdeo, Shenita, Buzescu, Adela, Landry, Ishani Savant, Jariwala, Navin, Turley, Wesley, Burrell, Richard, Arnold, Mark E.

“…Dried saliva spot (DSS) sampling is a non-invasive sample collection technique for bioanalysis that can be potentially implemented at the patient's home. A…”
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Alternative high-performance liquid chromatographic assay for p-aminohippuric acid (PAH): effect of aging on PAH excretion in the isolated perfused rat kidney by Savant, Ishani A, Kalis, Michelle, Almoazen, Hassan, Ortiz, Stephan R, AbuTarif, Malaz, Taft, David R

“…Para-aminohippuric acid (PAH), an indicator of renal plasma flow, is a commonly used marker of organic anion transport by the kidney. An analytical method for…”
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A validated HPLC–MS/MS assay for quantifying unstable pharmacologically active metabolites of clopidogrel in human plasma: Application to a clinical pharmacokinetic study by Furlong, Michael T., Savant, Ishani, Yuan, Moucun, Scott, Laura, Mylott, William, Mariannino, Thomas, Kadiyala, Pathanjali, Roongta, Vikram, Arnold, Mark E.

“…► Assay to quantify four chemically reactive thiol metabolites of clopidogrel. ► Stabilization of the thiol group by alkylation with…”
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Assessment of the drug-drug interaction between avagacestat (BMS-708163) and clopidogrel, carvedilol or diltiazem in healthy subjects by Savant, Ishani, He, Bing, Reeves, Richard, Sverdlov, Oleksandr, AbuTarif, Malaz

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P1‐220: Assessment of the drug‐drug interaction between avagacestat (BMS‐708163) and clopidogrel, carvedilol or diltiazem in healthy subjects by Savant, Ishani, He, Bing, Reeves, Richard, Sverdlov, Oleksandr, AbuTarif, Malaz

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P3–303: A randomized, double‐blind, placebo‐controlled, multiple ascending dose study to evaluate the safety, tolerability and pharmacokinetics of a microtubule stabilizer (BMS‐241027) in healthy females by Malamut, Richard, Wang, Jun‐Sheng, Savant, Ishani, Xiao, Hong, Sverdlov, Oleksandr, Tendolkar, Amol V., Keswani, Sanjay C.

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A randomized, double-blind, placebo-controlled, multiple ascending dose study to evaluate the safety, tolerability and pharmacokinetics of a microtubule stabilizer (BMS-241027) in healthy females by Malamut, Richard, Wang, Jun-Sheng, Savant, Ishani, Xiao, Hong, Sverdlov, Oleksandr, Tendolkar, Amol V, Keswani, Sanjay C

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[P1–056]: POPULATION PHARMACOKINETIC‐PHARMACODYNAMIC (PK/PD) MODELING OF E2027, A SELECTIVE PHOSPHODIESTERASE‐9 (PDE9) INHIBITOR, FOLLOWING SINGLE ASCENDING ORAL DOSES IN HEALTHY VOLUNTEERS by Schuck, Edgar L., Lai, Robert Y.K., Aluri, Jagadeesh, Hussein, Ziad, Ino, Mitsuhiro, Kotani, Sadaharu, Chang, Min‐Kun, Savant‐Landry, Ishani, Luthman, Johan

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Influence of gender on renal secretion of organic anions by Savant, Ishani A

“…An isolated perfused rat kidney (IPK) technique was utilized to study gender effects on the renal elimination of the organic anions p-aminohippurate (PAH) and…”
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POPULATION PHARMACOKINETIC-PHARMACODYNAMIC (PK/PD) MODELING OF E2027, A SELECTIVE PHOSPHODIESTERASE-9 (PDE9) INHIBITOR, FOLLOWING SINGLE ASCENDING ORAL DOSES IN HEALTHY VOLUNTEERS by Schuck, Edgar L., Lai, Robert Y.K., Aluri, Jagadeesh, Hussein, Ziad, Ino, Mitsuhiro, Kotani, Sadaharu, Chang, Min-Kun, Savant-Landry, Ishani, Luthman, Johan

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