Search Results - "Savage, Trisha"

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs by Borromeo, Mark D., Savage, Trisha K., Kollipara, Rahul K., He, Min, Augustyn, Alexander, Osborne, Jihan K., Girard, Luc, Minna, John D., Gazdar, Adi F., Cobb, Melanie H., Johnson, Jane E.

“…Small cell lung carcinoma (SCLC) is a high-grade pulmonary neuroendocrine tumor. The transcription factors ASCL1 and NEUROD1 play crucial roles in promoting…”
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Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis by Zhu, Mingrui, Huang, Yi, Bender, Matthew E, Girard, Luc, Kollipara, Rahul, Eglenen-Polat, Buse, Naito, Yujiro, Savage, Trisha K, Huffman, Kenneth E, Koyama, Shohei, Kumanogoh, Atsushi, Minna, John D, Johnson, Jane E, Akbay, Esra A

“…Small cell lung cancer (SCLC) is a pulmonary neuroendocrine cancer with very poor prognosis and limited effective therapeutic options. Most patients are…”
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Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells by Wang, Xu-Dong, Hu, Rongkuan, Ding, Qing, Savage, Trisha K., Huffman, Kenneth E., Williams, Noelle, Cobb, Melanie H., Minna, John D., Johnson, Jane E., Yu, Yonghao

“…Pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC), is a particularly aggressive malignancy. The lineage-specific transcription…”
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The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung by Gazdar, Adi F, Savage, Trisha K, Johnson, Jane E, Berns, Anton, Sage, Julien, Linnoila, R Ilona, MacPherson, David, McFadden, David G, Farago, Anna, Jacks, Tyler, Travis, William D, Brambilla, Elisabeth

“…Because small-cell lung carcinomas (SCLC) are seldom resected, human materials for study are limited. Thus, genetically engineered mouse models (GEMMs) for…”
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Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons by Mona, Bishakha, Villarreal, Juan, Savage, Trisha K, Kollipara, Rahul K, Boisvert, Brooke E, Johnson, Jane E

“…Peripheral somatosensory input is modulated in the dorsal spinal cord by a network of excitatory and inhibitory interneurons. PTF1A is a transcription factor…”
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Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1 by Rodarte, Kathia E, Nir Heyman, Shaked, Guo, Lei, Flores, Lydia, Savage, Trisha K, Villarreal, Juan, Deng, Su, Xu, Lin, Shah, Rajal B, Oliver, Trudy G, Johnson, Jane E

“…Most patients with prostate adenocarcinoma develop resistance to therapies targeting the androgen receptor (AR). Consequently, a portion of these patients…”
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Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord by Battiste, James, Helms, Amy W, Kim, Euiseok J, Savage, Trisha K, Lagace, Diane C, Mandyam, Chitra D, Eisch, Amelia J, Miyoshi, Goichi, Johnson, Jane E

“…The neural basic helix-loop-helix transcription factor Ascl1 (previously Mash1) is present in ventricular zone cells in restricted domains throughout the…”
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Ascl1 and Neurog2 form novel complexes and regulate Delta-like3 (Dll3) expression in the neural tube by Henke, R. Michael, Meredith, David M., Borromeo, Mark D., Savage, Trisha K., Johnson, Jane E.

“…Delta-like 3 (Dll3) is a Delta family member expressed broadly in the developing nervous system as neural progenitor cells initiate differentiation. A proximal…”
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Program Specificity for Ptf1a in Pancreas versus Neural Tube Development Correlates with Distinct Collaborating Cofactors and Chromatin Accessibility by Meredith, David M., Borromeo, Mark D., Deering, Tye G., Casey, Bradford H., Savage, Trisha K., Mayer, Paul R., Hoang, Chinh, Tung, Kuang-Chi, Kumar, Manonmani, Shen, Chengcheng, Swift, Galvin H., MacDonald, Raymond J., Johnson, Jane E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Neurogenin 1 (Neurog1) expression in the ventral neural tube is mediated by a distinct enhancer and preferentially marks ventral interneuron lineages by Quiñones, Herson I., Savage, Trisha K., Battiste, James, Johnson, Jane E.

“…The bHLH transcription factor Neurog1 (Ngn1, Neurod3, neurogenin 1) is involved in neuronal differentiation and cell-type specification in distinct regions of…”
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Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord by Henke, R Michael, Savage, Trisha K, Meredith, David M, Glasgow, Stacey M, Hori, Kei, Dumas, Judy, MacDonald, Raymond J, Johnson, Jane E

“…PTF1-J is a trimeric transcription factor complex essential for generating the correct balance of GABAergic and glutamatergic interneurons in multiple regions…”
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Overexpression of MATH1 Disrupts the Coordination of Neural Differentiation in Cerebellum Development by Helms, Amy W., Gowan, Katherine, Abney, Andrew, Savage, Trisha, Johnson, Jane E.

“…An essential role for the bHLH transcription factor MATH1 in the formation of cerebellar granule cells was previously demonstrated in a Math1 null mouse. The…”
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Induction of Innate Immune Visibility of Neuroendocrine Tumors Potentiates Immune Responses and Tumor Rejection by Zhu, Mingrui, Huang, Yi, Bender, Matthew, Girard, Luc, Kollipara, Rahul, Eglenen-Polat, Buse, Naito, Yujiro, Savage, Trisha, Huffman, Kenneth, Koyama, Shohei, Kumanogoh, Atsushi, Minna, John, Johnson, Jane, Akbay, Esra

“…Natural killer (NK) cells serve as an important role in suppressing tumor growth by directly attacking malignant cells. These cells recognize the tumor cells…”
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Abstract PR004: Exploring the role of ASCL1 in neuroendocrine prostate cancer by Rodarte, Kathia E., Flores, Lydia, Kandagatla, Vishal, Villarreal, Juan, Savage, Trisha K., Deng, Su, Mu, Ping, Shah, Rajal B., Oliver, Trudy G., Johnson, Jane E.

“…Most patients with prostate adenocarcinoma (PAd), an androgen receptor (AR) driven cancer, develop resistance to therapies targeting AR. Consequently, a…”
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Lineage-specific regulation of the neural differentiation gene MASH1 by Verma-Kurvari, S, Savage, T, Gowan, K, Johnson, J E

“…Mash1 is a transcription factor required during embryogenesis for the development of multiple neural lineages. It is expressed in restricted domains at…”
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Multiple elements regulate Mash1 expression in the developing CNS by Verma-Kurvari, S, Savage, T, Smith, D, Johnson, J E

“…Mash1, a transcription factor of the basic helix-loop-helix class, is expressed during embryogenesis in restricted regions of the nervous system. An essential…”
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Multiple Elements RegulateMash1Expression in the Developing CNS by Verma-Kurvari, Sunita, Savage, Trisha, Smith, Derek, Johnson, Jane E.

“…Mash1, a transcription factor of the basic helix–loop–helix class, is expressed during embryogenesis in restricted regions of the nervous system. An essential…”
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Parental 5-methylcytosine methylation patterns are stable upon inter-species hybridization of Xiphophorus (Teleostei: Poeciliidae) fish by Li, Hai-Ying, Savage, Trisha, Obermoeller, Rebecca D, Kazianis, Steven, Walter, Ronald B

“…Cytosine methylation appears to be established as an important DNA base modification involved in regulation of gene expression but is poorly understood from an…”
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Lineage-Specific Regulation of the Neural Differentiation GeneMASH1 by Verma-Kurvari, Sunita, Savage, Trisha, Gowan, Katherine, Johnson, Jane E.

“…Mash1 is a transcription factor required during embryogenesis for the development of multiple neural lineages. It is expressed in restricted domains at…”
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