Search Results - "Savage, Paula"

The importance of male underwear in cases of alleged sexual assault by Flanagan, Lorna, Murphy, Charlotte, Savage, Paula, Breathnach, Michelle, Ryan, Jennifer

“…The potential evidential value of male underwear in cases of alleged sexual assault is often overlooked. Male underwear can be a critical item in the…”
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Isoindolines: A new series of potent and selective endothelin-A receptor antagonists by Kukkola, Paivi J., Bilci, Natalie A., Ikler, Theodore, Savage, Paula, Shetty, Suraj S., DelGrande, Dominick, Jeng, Arco Y.

“…1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET A selective receptor antagonists through pharmacophore analysis of…”
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Design and Synthesis of Potent, Selective Inhibitors of Endothelin-Converting Enzyme by Wallace, Eli M, Moliterni, John A, Moskal, Michael A, Neubert, Alan D, Marcopulos, Nicholas, Stamford, Lisa B, Trapani, Angelo J, Savage, Paula, Chou, Mary, Jeng, Arco Y

“…Endothelin-1 is the most potent peptidic vasoconstrictor discovered to date. The final step of posttranslational processing of this peptide is the conversion…”
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Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11 by De Lombaert, Stéphane, Stamford, Lisa B., Blanchard, Louis, Tan, Jenny, Hoyer, Denton, Diefenbacher, Clive G., Wei, Dongchu, Wallace, Eli M., Moskal, Michael A., Savage, Paula, Jeng, Arco Y.

“…Structural modifications of CGS 26303, a non-peptidic α-aminophosphonate dual ECE/NEP inhibitor lead, were performed to maximize inhibition of recombinant…”
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Early thymus and activation-regulated chemokine (TARC) reduction and response following panobinostat treatment in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplant by Harrison, Simon J., Hsu, Andy K., Neeson, Paul, Younes, Anas, Sureda, Anna, Engert, Andreas, Prince, H. Miles, Li, Martha, Savage, Paula, Bugarini, Roberto, Williams, Denise, Squier, Margaret, Ritchie, David S.

“…Abstract In a phase 2 trial of panobinostat in 129 patients with relapsed or refractory Hodgkin lymphoma, exploratory analyses of chemokines and cytokines were…”
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Identification and partial purification of a thiol endothelin-converting enzyme from porcine aortic endothelial cells by Deng, Y, Savage, P, Shetty, S S, Martin, L L, Jeng, A Y

“…Endothelin is a potent peptide vasoconstrictor. The final step in the processing of endothelin has been postulated to be the cleavage of the Trp21-Val22…”
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Potent and Selective Non-Peptidic Inhibitors of Endothelin-Converting Enzyme-1 with Sustained Duration of Action by De Lombaert, Stéphane, Blanchard, Louis, Stamford, Lisa B, Tan, Jenny, Wallace, Eli M, Satoh, Yoshitaka, Fitt, John, Hoyer, Denton, Simonsbergen, David, Moliterni, John, Marcopoulos, Nicholas, Savage, Paula, Chou, Mary, Trapani, Angelo J, Jeng, Arco Y

“…Potent and selective non-peptidic inhibitors of human endothelin-converting enzyme-1 (ECE-1) have been designed as potential modulators of endothelin (ET-1)…”
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Safety, Pharmacokinetics (PK), Metabolism, and Mass Balance of [14C]-AMN107, a Novel Aminopyrimidine Inhibitor of Bcr-Abl Tyrosine Kinase, in Healthy Subjects by Kagan, Mark, Tran, Phi, Fischer, Volker, Savage, Paula, Smith, Tom, Tanaka, Chiaki, Schran, Horst, Narurkar, Milind, Alland, Leila

“…Background: AMN107, a selective and potent inhibitor of Bcr-Abl tyrosine kinase signaling, has demonstrated activity against imatinib resistant forms of…”
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Upregulation of endothelin-1 binding in tissues of salt-loaded stroke-prone spontaneously hypertensive rats by Savage, Paula, Jeng, Arco Y

“…Upon maintained on a 1% NaCl drinking solution beginning at 7 weeks of age, the stroke-prone spontaneously hypertensive rat (SHRsp) developed severe…”
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CGS 35601 and its Orally Active Prodrug CGS 37808 as Triple Inhibitors of Endothelin-converting Enzyme-1, Neutral Endopeptidase 24.11, and Angiotensin-converting Enzyme by Trapani, Angelo J, Beil, Michael E, Bruseo, Charles W, Savage, Paula, Firooznia, Fariborz, Jeng, Arco Y

“…CGS 35601 is a potent triple inhibitor of endothelinconverting enzyme-1, neutral endopeptidase 24.11, and angiotensinconverting enzyme. It inhibited the…”
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CGS 34226, a thiol-based dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11 by Jeng, Arco Y, Savage, Paula, Beil, Michael E, Bruseo, Charles W, Hoyer, Denton, Fink, Cynthia A, Trapani, Angelo J

“…Endothelins (ETs) are potent vasoconstrictors and have been implicated in the pathogenesis of various cardiovascular and renal diseases. In contrast, atrial…”
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Synthesis and biological activity of potent heterocyclic thiol-based inhibitors of endothelin-converting enzyme-1 by Firooznia, Fariborz, Gude, Candido, Chan, Kenneth, Tan, Jenny, Fink, Cynthia A., Savage, Paula, Beil, Michael E., Bruseo, Charles W., Trapani, Angelo J., Jeng, Arco Y.

“…Directed screening of metalloprotease inhibitors identified CGS 30084 ( 1) as a potent inhibitor of endothelin-converting enzyme-1 (ECE-1) in vitro (IC 50=77…”
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Effects of the ECE/NEP inhibitor CGS 34225 on the big ET-1-induced pressor response and plasma atrial natriuretic peptide concentration in conscious rats by Trapani, Angelo J, Beil, Michael E, Bruseo, Charles W, Fink, Cynthia A, Hoyer, Denton, Savage, Paula, Jeng, Arco Y

“…CGS 34226 is a thiol-containing, potent dual inhibitor of endothelin converting enzyme-1 (ECE-1) and neutral endopeptidase 24.11 (NEP) with IC(50) values of 11…”
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Oral administration of an inhibitor of endothelin-converting enzyme attenuates cerebral vasospasm following experimental subarachnoid haemorrhage in rabbits by Kwan, Aij-Lie, Lin, Chih-Lung, Chang, Chih-Zen, Winardi, Daniel, Yen, Chun-Po, Wu, Shu-Chuan, Lee, Kevin S, Kassell, Neal F, Howng, Shen-Long, Savage, Paula, Jeng, Arco Y

“…Increasing evidence has implicated endothelin-1 (ET-1), a potent vasoconstrictive peptide, in the pathophysiology of cerebral vasospasm after subarachnoid…”
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Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a by Kulathila, Raviraj, Clark, Kirk, Savage, Paula, Bowen, Benjamin R, Emoto, Noriaki, Yanagisawa, Masashi, Jeng, Arco Y

“…In this study, the catalytic domain of bovine endothelin converting enzyme-1a (ECE-1a) was cloned into a baculovirus transfer vector behind the human alkaline…”
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Cgs 34043 by Trapani, Angelo J., De Lombaert, Stéphane, Beil, Michael E., Bruseo, Charles W., Savage, Paula, Chou, Mary, Jeng, Arco Y.

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Activation of BK Ca channel via endothelin ET A receptors in porcine coronary artery smooth muscle cells by Hu, Shiling, Kim, Helen S, Savage, Paula, Jeng, Arco Y

“…It has been demonstrated previously that endothelin-1 stimulates the Ca 2+-activated K + (BK Ca) channel activity in porcine coronary artery smooth muscle…”
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Design and Synthesis of a Potent and Selective Endothelin-Converting Enzyme Inhibitor, CGS 35066 by Jeng, Arco Y, De Lombaert, Stéphane, Beil, Michael E, Bruseo, Charles W, Savage, Paula, Chou, Mary, Trapani, Angelo J

“…CGS 26303 has previously been shown to inhibit human endothelin converting enzyme-1 (ECE-1) with an IC50 of 410 nM and to be efficacious in several animal…”
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Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1 by Fink, Cynthia A, Moskal, Michael, Firooznia, Fariborz, Hoyer, Denton, Symonsbergen, David, Wei, Dongchu, Qiao, Ying, Savage, Paula, Beil, Michael E, Trapani, Angelo J, Jeng, Arco Y

“…Through directed screening of compounds prepared as metalloprotease inhibitors a compound, CGS 30084, that had potent endothelin converting enzyme-1 (ECE-1) in…”
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Cgs 34043: A non-peptidic, potent and long-acting dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11 by Trapani, Angelo J., De Lombaert, Stéphane, Beil, Michael E., Bruseo, Charles W., Savage, Paula, Chou, Mary, Jeng, Arco Y.

“…Endothelin-1 (ET-1) is a potent vasoconstrictor. Its biosynthesis is catalyzed by endothelin converting enzyme (ECE). In contrast, atrial natriuretic peptide…”
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