Search Results - "Savage, I"

BRCA1, a ‘complex’ protein involved in the maintenance of genomic stability by Savage, Kienan I., Harkin, D. Paul

“…BRCA1 is a major breast and ovarian cancer susceptibility gene, with mutations in this gene predisposing women to a very high risk of developing breast and…”
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Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer by Bollu, Lakshmi Reddy, Mazumdar, Abhijit, Savage, Michelle I, Brown, Powel H

“…The aberrant activation of oncogenic signaling pathways is a universal phenomenon in cancer and drives tumorigenesis and malignant transformation. This…”
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Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer by Burstein, Matthew D, Tsimelzon, Anna, Poage, Graham M, Covington, Kyle R, Contreras, Alejandro, Fuqua, Suzanne A W, Savage, Michelle I, Osborne, C Kent, Hilsenbeck, Susan G, Chang, Jenny C, Mills, Gordon B, Lau, Ching C, Brown, Powel H

“…Genomic profiling studies suggest that triple-negative breast cancer (TNBC) is a heterogeneous disease. In this study, we sought to define TNBC subtypes and…”
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Molecularly targeted therapies for p53-mutant cancers by Zhao, Dekuang, Tahaney, William M., Mazumdar, Abhijit, Savage, Michelle I., Brown, Powel H.

“…The tumor suppressor p53 is lost or mutated in approximately half of human cancers. Mutant p53 not only loses its anti-tumor transcriptional activity, but also…”
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Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability by Savage, Kienan I., Gorski, Julia J., Barros, Eliana M., Irwin, Gareth W., Manti, Lorenzo, Powell, Alexander J., Pellagatti, Andrea, Lukashchuk, Natalia, McCance, Dennis J., McCluggage, W. Glenn, Schettino, Giuseppe, Salto-Tellez, Manuel, Boultwood, Jacqueline, Richard, Derek J., McDade, Simon S., Harkin, D. Paul

“…Mutations within BRCA1 predispose carriers to a high risk of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through the assembly of…”
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The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export by Vohhodina, Jekaterina, Barros, Eliana M, Savage, Abigail L, Liberante, Fabio G, Manti, Lorenzo, Bankhead, Peter, Cosgrove, Nicola, Madden, Angelina F, Harkin, D Paul, Savage, Kienan I

“…mRNA splicing and export plays a key role in the regulation of gene expression, with recent evidence suggesting an additional layer of regulation of gene…”
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Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy by Ali, Rayhaan M. M., McIntosh, Stuart A., Savage, Kienan I.

“…An underlying cause of breast cancers has been largely attributed to defects in the DNA damage response (DDR) pathway. In particular, the homologous…”
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Use of the γ-H2AX assay to investigate DNA repair dynamics following multiple radiation exposures by Mariotti, Luca G, Pirovano, Giacomo, Savage, Kienan I, Ghita, Mihaela, Ottolenghi, Andrea, Prise, Kevin M, Schettino, Giuseppe

“…Radiation therapy is one of the most common and effective strategies used to treat cancer. The irradiation is usually performed with a fractionated scheme,…”
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Targeted therapy for breast cancer prevention by den Hollander, Petra, Savage, Michelle I, Brown, Powel H

“…With a better understanding of the etiology of breast cancer, molecularly targeted drugs have been developed and are being testing for the treatment and…”
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The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin by Kalousi, Alkmini, Hoffbeck, Anne-Sophie, Selemenakis, Platonas N., Pinder, Jordan, Savage, Kienan I., Khanna, Kum Kum, Brino, Laurent, Dellaire, Graham, Gorgoulis, Vassilis G., Soutoglou, Evi

“…Cells experience damage from exogenous and endogenous sources that endanger genome stability. Several cellular pathways have evolved to detect DNA damage and…”
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Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells by Dolatshad, H, Pellagatti, A, Fernandez-Mercado, M, Yip, B H, Malcovati, L, Attwood, M, Przychodzen, B, Sahgal, N, Kanapin, A A, Lockstone, H, Scifo, L, Vandenberghe, P, Papaemmanuil, E, Smith, C W J, Campbell, P J, Ogawa, S, Maciejewski, J P, Cazzola, M, Savage, K I, Boultwood, J

“…The splicing factor SF3B1 is the most commonly mutated gene in the myelodysplastic syndrome (MDS), particularly in patients with refractory anemia with ring…”
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Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes by Dolatshad, H, Pellagatti, A, Liberante, F G, Llorian, M, Repapi, E, Steeples, V, Roy, S, Scifo, L, Armstrong, R N, Shaw, J, Yip, B H, Killick, S, Kušec, R, Taylor, S, Mills, K I, Savage, K I, Smith, C W J, Boultwood, J

“…The splicing factor SF3B1 is the most frequently mutated gene in myelodysplastic syndromes (MDS), and is strongly associated with the presence of ring…”
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The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth by Qian, Jing, Ma, Yanxia, Tahaney, William M, Moyer, Cassandra L, Lanier, Amanda, Hill, Jamal, Coleman, Darian, Koupaei, Negar, Hilsenbeck, Susan G, Savage, Michelle I, Page, Brent D G, Mazumdar, Abhijit, Brown, Powel H

“…The most aggressive form of breast cancer is triple-negative breast cancer (TNBC), which lacks expression of the estrogen receptor (ER) and progesterone…”
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Correction: The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth by Qian, Jing, Ma, Yanxia, Tahaney, William M, Moyer, Cassandra L, Lanier, Amanda, Hill, Jamal, Coleman, Darian, Koupaei, Negar, Hilsenbeck, Susan G, Savage, Michelle I, Page, Brent D G, Mazumdar, Abhijit, Brown, Powel H

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BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability by SAVAGE, Kienan I, MATCHETT, Kyle B, POWELL, Alexander, MANTI, Lorenzo, MCDADE, Simon S, BEN HO PARK, PRISE, Kevin M, MCINTOSH, Stuart A, SALTO-TELLEZ, Manuel, RICHARD, Derek J, ELLIOTT, Christopher T, HARKIN, D. Paul, BARROS, Eliana M, COOPER, Kevin M, IRWIN, Gareth W, GORSKI, Julia J, ORR, Katy S, VOHHODINA, Jekaterina, KAVANAGH, Joy N, MADDEN, Angelina F

“…Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through…”
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Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML by Smith, James S, Lappin, Katrina M, Craig, Stephanie G, Liberante, Fabio G, Crean, Clare M, McDade, Simon S, Thompson, Alexander, Mills, Ken I, Savage, Kienan I

“…The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early…”
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BRD7, a Subunit of SWI/SNF Complexes, Binds Directly to BRCA1 and Regulates BRCA1-Dependent Transcription by HARTE, Mary T, O'BRIEN, Garrett J, RYAN, Niamh M, GORSKI, Julia J, SAVAGE, Kienan I, CRAWFORD, Nyree T, MULLAN, Paul B, HARKIN, D. Paul

“…We carried out a yeast two-hybrid screen using a BRCA1 bait composed of amino acids 1 to 1142 and identified BRD7 as a novel binding partner of BRCA1. This…”
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NF-κB is a critical mediator of BRCA1-induced chemoresistance by Harte, M T, Gorski, J J, Savage, K I, Purcell, J W, Barros, E M, Burn, P M, McFarlane, C, Mullan, P B, Kennedy, R D, Perkins, N D, Harkin, D P

“…BRCA1 mediates resistance to apoptosis in response to DNA-damaging agents, causing BRCA1 wild-type tumours to be significantly more resistant to DNA damage…”
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Multifocal breast cancers are more prevalent in BRCA2 versus BRCA1 mutation carriers by McCrorie, Alan D, Ashfield, Susannah, Begley, Aislinn, Mcilmunn, Colin, Morrison, Patrick J, Boyd, Clinton, Eccles, Bryony, Greville‐Heygate, Stephanie, Copson, Ellen R, Cutress, Ramsey I, Eccles, Diana M, Savage, Kienan I, McIntosh, Stuart A

“…Multifocal (MF)/multicentric (MC) breast cancer is generally considered to be where two or more breast tumours are present within the same breast, and is seen…”
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COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks by Suraweera, Amila, Gandhi, Neha S., Beard, Sam, Burgess, Joshua T., Croft, Laura V., Bolderson, Emma, Naqi, Ali, Ashton, Nicholas W., Adams, Mark N., Savage, Kienan I., Zhang, Shu-Dong, O’Byrne, Kenneth J., Richard, Derek J.

“…Genomic stability is critical for normal cellular function and its deregulation is a universal hallmark of cancer. Here we outline a previously undescribed…”
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