Search Results - "Savage, David B"

What lipodystrophies teach us about the metabolic syndrome by Mann, Jake P, Savage, David B

“…Lipodystrophies are the result of a range of inherited and acquired causes, but all are characterized by perturbations in white adipose tissue function and, in…”
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Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance by Savage, David B, Petersen, Kitt Falk, Shulman, Gerald I

“…Departments of Internal Medicine and Cellular and Molecular Physiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven,…”
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The genetics of lipid storage and human lipodystrophies by Robbins, Ann L, Savage, David B

“…Highlights • In vertebrates, adipocytes store surplus energy within a large unilocular lipid droplet. • Lipid accumulation in non-adipose tissue is seen when…”
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Prospective functional classification of all possible missense variants in PPARG by Majithia, Amit R, Tsuda, Ben, Agostini, Maura, Gnanapradeepan, Keerthana, Rice, Robert, Peloso, Gina, Patel, Kashyap A, Zhang, Xiaolan, Broekema, Marjoleine F, Patterson, Nick, Duby, Marc, Sharpe, Ted, Kalkhoven, Eric, Rosen, Evan D, Barroso, Inês, Ellard, Sian, Kathiresan, Sekar, O'Rahilly, Stephen, Chatterjee, Krishna, Florez, Jose C, Mikkelsen, Tarjei, Savage, David B, Altshuler, David

“…Amit Majithia and colleagues employ a pooled assay in human macrophages to assess the functional effects of all possible missense variants in PPARG . Their…”
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Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1–3 by Rowe, Emily R., Mimmack, Michael L., Barbosa, Antonio D., Haider, Afreen, Isaac, Iona, Ouberai, Myriam M., Thiam, Abdou Rachid, Patel, Satish, Saudek, Vladimir, Siniossoglou, Symeon, Savage, David B.

“…Perilipins (PLINs) play a key role in energy storage by orchestrating the activity of lipases on the surface of lipid droplets. Failure of this activity…”
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Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization by Barbosa, Antonio D., Lim, Koini, Mari, Muriel, Edgar, James R., Gal, Lihi, Sterk, Peter, Jenkins, Benjamin J., Koulman, Albert, Savage, David B., Schuldiner, Maya, Reggiori, Fulvio, Wigge, Philip A., Siniossoglou, Symeon

“…Cells dynamically adjust organelle organization in response to growth and environmental cues. This requires regulation of synthesis of phospholipids, the…”
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PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress by Haider, Afreen, Wei, Yu-Chen, Lim, Koini, Barbosa, Antonio D., Liu, Che-Hsiung, Weber, Ursula, Mlodzik, Marek, Oras, Kadri, Collier, Simon, Hussain, M. Mahmood, Dong, Liang, Patel, Satish, Alvarez-Guaita, Anna, Saudek, Vladimir, Jenkins, Benjamin J., Koulman, Albert, Dymond, Marcus K., Hardie, Roger C., Siniossoglou, Symeon, Savage, David B.

“…Cell and organelle membranes consist of a complex mixture of phospholipids (PLs) that determine their size, shape, and function. Phosphatidylcholine (PC) is…”
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Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis by Patel, Satish, Yang, Wei, Kozusko, Kristina, Saudek, Vladimir, Savage, David B.

“…Lipid droplets (LDs) are a conserved feature of most organisms. Vertebrate adipocytes have evolved to efficiently store and release lipids for the whole…”
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Lipodystrophy: metabolic insights from a rare disorder by Huang-Doran, Isabel, Sleigh, Alison, Rochford, Justin J, O'Rahilly, Stephen, Savage, David B

“…Obesity, insulin resistance and their attendant complications are among the leading causes of morbidity and premature mortality today, yet we are only in the…”
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role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome by Petersen, Kitt Falk, Dufour, Sylvie, Savage, David B, Bilz, Stefan, Solomon, Gina, Yonemitsu, Shin, Cline, Gary W, Befroy, Douglas, Zemany, Laura, Kahn, Barbara B, Papademetris, Xenophon, Rothman, Douglas L, Shulman, Gerald I

“…We examined the hypothesis that insulin resistance in skeletal muscle promotes the development of atherogenic dyslipidemia, associated with the metabolic…”
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Accumulation of saturated intramyocellular lipid is associated with insulin resistance[S] by Savage, David B., Watson, Laura, Carr, Katie, Adams, Claire, Brage, Soren, Chatterjee, Krishna K., Hodson, Leanne, Boesch, Chris, Kemp, Graham J., Sleigh, Alison

“…Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of…”
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Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease by Payne, Felicity, Lim, Koini, Girousse, Amandine, Brown, Rebecca J., Kory, Nora, Robbins, Ann, Xue, Yali, Sleigh, Alison, Cochran, Elaine, Adams, Claire, Borman, Arundhati Dev, Russel-Jones, David, Gorden, Phillip, Semple, Robert K., Saudek, Vladimir, O'Rahilly, Stephen, Walther, Tobias C., Barroso, Inês, Savage, David B.

“…Phosphatidylcholine (PC) is the major glycerophospholipid in eukaryotic cells and is an essential component in all cellular membranes. The biochemistry of de…”
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Mouse models of inherited lipodystrophy by Savage, David B

“…Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and underpins the strong association between obesity and diabetes. Paradoxically,…”
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Perilipin Deficiency and Autosomal Dominant Partial Lipodystrophy by Gandotra, Sheetal, Le Dour, Caroline, Bottomley, William, Cervera, Pascale, Giral, Philippe, Reznik, Yves, Charpentier, Guillaume, Auclair, Martine, Delépine, Marc, Barroso, Inês, Semple, Robert K, Lathrop, Mark, Lascols, Olivier, Capeau, Jacqueline, O'Rahilly, Stephen, Magré, Jocelyne, Savage, David B, Vigouroux, Corinne

“…Perilipin, the most abundant adipocyte-specific lipid-droplet coat protein, is required for optimal lipid incorporation and release from the droplet. The…”
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Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis by Nead, Kevin T, Sharp, Stephen J, Thompson, Deborah J, Painter, Jodie N, Savage, David B, Semple, Robert K, Barker, Adam, Perry, John R B, Attia, John, Dunning, Alison M, Easton, Douglas F, Holliday, Elizabeth, Lotta, Luca A, O'Mara, Tracy, McEvoy, Mark, Pharoah, Paul D P, Scott, Rodney J, Spurdle, Amanda B, Langenberg, Claudia, Wareham, Nicholas J, Scott, Robert A

“…Insulinemia and type 2 diabetes (T2D) have been associated with endometrial cancer risk in numerous observational studies. However, the causality of these…”
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Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice by Zhou, Linkang, Park, Shi-Young, Xu, Li, Xia, Xiayu, Ye, Jing, Su, Lu, Jeong, Kyeong-Hoon, Hur, Jang Ho, Oh, Hyunhee, Tamori, Yoshikazu, Zingaretti, Cristina M., Cinti, Saverio, Argente, Jesús, Yu, Miao, Wu, Lizhen, Ju, Shenghong, Guan, Feifei, Yang, Hongyuan, Choi, Cheol Soo, Savage, David B., Li, Peng

“…Fsp27 is a lipid droplet-associated protein almost exclusively expressed in adipocytes where it facilitates unilocular lipid droplet formation. In mice, Fsp27…”
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The architecture of Cidec-mediated interfaces between lipid droplets by Ganeva, Iva, Lim, Koini, Boulanger, Jerome, Hoffmann, Patrick C., Muriel, Olivia, Borgeaud, Alicia C., Hagen, Wim J.H., Savage, David B., Kukulski, Wanda

“…Lipid droplets (LDs) are intracellular organelles responsible for storing surplus energy as neutral lipids. Their size and number vary enormously. In white…”
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Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis by Semple, Robert K, Sleigh, Alison, Murgatroyd, Peter R, Adams, Claire A, Bluck, Les, Jackson, Sarah, Vottero, Alessandra, Kanabar, Dipak, Charlton-Menys, Valentine, Durrington, Paul, Soos, Maria A, Carpenter, T Adrian, Lomas, David J, Cochran, Elaine K, Gorden, Phillip, O'Rahilly, Stephen, Savage, David B

“…Metabolic dyslipidemia is characterized by high circulating triglyceride (TG) and low HDL cholesterol levels and is frequently accompanied by hepatic…”
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Human Frame Shift Mutations Affecting the Carboxyl Terminus of Perilipin Increase Lipolysis by Failing to Sequester the Adipose Triglyceride Lipase (ATGL) Coactivator AB-hydrolase-containing 5 (ABHD5) by Gandotra, Sheetal, Lim, Koini, Girousse, Amandine, Saudek, Vladimir, O'Rahilly, Stephen, Savage, David B.

“…Perilipin (PLIN1) is a constitutive adipocyte lipid droplet coat protein. N-terminal amphipathic helices and central hydrophobic stretches are thought to…”
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Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity by Choi, Cheol Soo, Savage, David B, Abu-Elheiga, Lutfi, Liu, Zhen-Xiang, Kim, Sheene, Kulkarni, Ameya, Distefano, Alberto, Hwang, Yu-Jin, Reznick, Richard M, Codella, Roberto, Zhang, Dongyan, Cline, Gary W, Wakil, Salih J, Shulman, Gerald I

“…Acetyl-CoA carboxylase 2 (ACC)2 is a key regulator of mitochondrial fat oxidation. To examine the impact of ACC2 deletion on whole-body energy metabolism, we…”
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