Search Results - "Savage, C O S"

Pathogenesis of anti‐neutrophil cytoplasmic autoantibody (ANCA)‐associated vasculitis by Savage, C. O. S.

“…Summary Anti‐neutrophil cytoplasmic autoantibody (ANCA)‐associated vasculitis is an autoimmune disease in which the contributions of genetic, epigenetic and…”
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Anti‐neutrophil cytoplasm antibody IgG subclasses in Wegener's granulomatosis: a possible pathogenic role for the IgG4 subclass by HOLLAND, M., HEWINS, P., GOODALL, M., ADU, D., JEFFERIS, R., SAVAGE, C. O. S.

“…SUMMARY A characteristic feature of Wegener's granulomatosis is the presence of antineutrophil cytoplasm antibodies (ANCA) to proteinase 3 (PR3). In vitro,…”
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Malignancy is increased in ANCA-associated vasculitis by Pankhurst, T., Savage, C. O. S., Gordon, C., Harper, L.

“…Objective. In the light of previous reports of an association between malignancy and renal vasculitis, we aimed to investigate the association of malignancy in…”
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Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion by CHAKRAVORTY, S. J., COCKWELL, P., GIRDLESTONE, J., BROOKS, C. J., SAVAGE, C. O. S.

“…SUMMARY Fractalkine (CX3CL1) is a transmembrane molecule with a CX3C chemokine domain attached to an extracellular mucin stalk which can induce both adhesion…”
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Mannose-binding lectin gene polymorphisms in a cohort study of ANCA-associated small vessel vasculitis by Kamesh, L., Heward, J. M., Williams, J. M., Gough, S. C. L., Savage, C. O. S., Harper, L.

“…Objective. To investigate whether single nucleotide polymorphisms (SNPs) within the mannose-binding lectin (MBL) gene are associated with small vessel…”
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The role of the endothelium in systemic small vessel vasculitis by LITTLE, M. A, SAVAGE, C. O. S

“…The endothelium is the back-drop against which the effects set in train by interactions between Anti-Neutrophil Cytoplasm Antibodies (ANCA) and neutrophils are…”
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Hypogalactosylation of serum IgG in patients with ANCA‐associated systemic vasculitis by HOLLAND, M., TAKADA, K., OKUMOTO, T., TAKAHASHI, N., KATO, K., ADU, D., BEN‐SMITH, A., HARPER, L., SAVAGE, C. O. S., JEFFERIS, R.

“…SUMMARY The triad of small vessel vasculitides (SVV) comprise Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg–Strauss syndrome (CS)…”
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Adjuvant treatment of patients with antineutrophil cytoplasmic antibody‐associated vasculitis with vitamins E and C reduces superoxide production by neutrophils by Harper, L., Nuttall, S. L., Martin, U., Savage, C. O. S.

“…Objectives. Neutrophils when activated generate a respiratory burst which has been implicated in the pathogenesis of primary systemic vasculitis. Neutrophils…”
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ANCA-associated vasculitides: advances in pathophysiology and treatment by ERWIG, L.-P, SAVAGE, C. O. S

“…Substantial progress has been made over the last two decades in our understanding of the immunopathogenesis of antineutrophil cytoplasmic antibodies (ANCA)…”
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Th2 dominance in nasal mucosa in patients with Wegener’s granulomatosis by Balding, C. E. J., Howie, A. J., Drake‐Lee, A. B., Savage, C. O. S.

“…Wegener's granulomatosis initially affects upper respiratory tract organs including the nasal mucosa in more than 90% of patients. The inflammation is…”
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ANCA-stimulated neutrophils release BLyS and promote B cell survival: a clinically relevant cellular process by Holden, N J, Williams, J M, Morgan, M D, Challa, A, Gordon, J, Pepper, R J, Salama, A D, Harper, L, Savage, C O S

“…To determine a role for antineutrophil cytoplasmic antibody (ANCA)-activated neutrophils in promoting B cell survival through the release of B lymphocyte…”
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Production of antineutrophil cytoplasm antibodies derived from circulating B cells in patients with systemic vasculitis by CLAYTON, A. R., SAVAGE, C. O. S.

“…SUMMARY The pathogenesis of systemic vasculitis is complex and is likely to involve many mechanisms. In certain systemic vasculitides, autoimmunity plays an…”
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Recommendations for the use of rituximab in anti-neutrophil cytoplasm antibody-associated vasculitis by GUERRY, Mary-Jane C. J, BROGAN, Paul, WATTS, Richard A, JAYNE, David R. W, BRUCE, Ian N, D'CRUZ, David P, HARPER, Lorraine, LUQMANI, Raashid, PUSEY, Charles D, SALAMA, Alan D, SCOTT, David G. I, SAVAGE, Caroline O. S

“…To perform a literature review and develop recommendations for the use of rituximab in ANCA-associated vasculitis. A committee of experts (five…”
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Neutrophil FcγRIIIb allelic polymorphism in anti‐neutrophil cytoplasmic antibody (ANCA)‐positive systemic vasculitis by Tse, W. Y., Abadeh, S., Jefferis, R., Savage, C. O. S., Adu, D.

“…Neutrophils constitutively express FcγRIIa and FcγRIIIb receptors. Both receptors exhibit allelic variants which have different quantitative functional…”
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Can neutrophils be manipulated in vivo? by Morgan, M. D., Harper, L., Lu, X., Nash, G., Williams, J., Savage, C. O. S.

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Vascular damage in Wegener's granulomatosis and microscopic polyarteritis: presence of anti‐endothelial cell antibodies and their relation to anti‐neutrophil cytoplasm antibodies by SAVAGE, C. O. S., POTTINGER, B. E., GASKIN, G., LOCKWOOD, C. M., PUSEY, C. D., PEARSON, J. D.

“…SUMMARY To define mechanisms of vascular injury in Wegener's granulomatosis and microscopic potyarteritis, anti‐endothelial cell antibodies (AECA) were sought…”
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Primary systemic vasculitis by Savage, C O, Harper, L, Adu, D

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Impact of compound heterozygous complement factor H mutations on development of atypical hemolytic uremic syndrome—A pedigree revisited by Johnson, S.A., Williams, J.M., Hakobyan, S., Richards, A., Perkins, S.J., Marchbank, K.J., Goodship, T.H.J., Morgan, B.P., Taylor, C.M., Savage, C.O.S.

“…Atypical hemolytic uremic syndrome (aHUS) is associated with mutations in the gene CFH encoding the complement regulator factor H (CFH). We previously reported…”
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Endothelium and regulatory cell interactions by Savage, C O S

“…Endothelial cells are injury targets in vasculitis and other diseases. However, their abilities to regulate their own fate are becoming increasingly recognized…”
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Chimeric antibodies to proteinase 3 of IgG1 and IgG3 subclasses induce different magnitudes of functional responses in neutrophils by Colman, Rachel, Hussain, Abdullah, Goodall, Margaret, Young, Steven P, Pankhurst, Tanya, Lu, Xiaomei, Jefferis, Royston, Savage, Caroline O S, Williams, Julie M

“…Background: Antineutrophil cytoplasmic antibodies (ANCA) are associated with small-vessel vasculitis and have been implicated in its pathogenesis. The subclass…”
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