Search Results - "Sauvageau, Martin"

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer by Sauvageau, Martin, Sauvageau, Guy

“…Polycomb Group (PcG) proteins are transcriptional repressors that epigenetically modify chromatin and participate in the establishment and maintenance of cell…”
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Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre by Hacisuleyman, Ezgi, Goff, Loyal A, Trapnell, Cole, Williams, Adam, Henao-Mejia, Jorge, Sun, Lei, McClanahan, Patrick, Hendrickson, David G, Sauvageau, Martin, Kelley, David R, Morse, Michael, Engreitz, Jesse, Lander, Eric S, Guttman, Mitch, Lodish, Harvey F, Flavell, Richard, Raj, Arjun, Rinn, John L

“…A long intergenic noncoding RNA, Firre, is now shown to localize to a domain across its own chromosomal locus and to distinct interacting transchromosomal loci…”
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Long noncoding RNAs regulate adipogenesis by Sun, Lei, Goff, Loyal A., Trapnell, Cole, Alexander, Ryan, Lo, Kinyui Alice, Hacisuleyman, Ezgi, Sauvageau, Martin, Tazon-Vega, Barbara, Kelley, David R., Hendrickson, David G., Yuan, Bingbing, Kellis, Manolis, Lodish, Harvey F., Rinn, John L.

“…The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes,…”
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Multiple knockout mouse models reveal lincRNAs are required for life and brain development by Sauvageau, Martin, Goff, Loyal A, Lodato, Simona, Bonev, Boyan, Groff, Abigail F, Gerhardinger, Chiara, Sanchez-Gomez, Diana B, Hacisuleyman, Ezgi, Li, Eric, Spence, Matthew, Liapis, Stephen C, Mallard, William, Morse, Michael, Swerdel, Mavis R, D'Ecclessis, Michael F, Moore, Jennifer C, Lai, Venus, Gong, Guochun, Yancopoulos, George D, Frendewey, David, Kellis, Manolis, Hart, Ronald P, Valenzuela, David M, Arlotta, Paola, Rinn, John L

“…Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in…”
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The Tug1 lncRNA locus is essential for male fertility by Lewandowski, Jordan P, Dumbović, Gabrijela, Watson, Audrey R, Hwang, Taeyoung, Jacobs-Palmer, Emily, Chang, Nydia, Much, Christian, Turner, Kyle M, Kirby, Christopher, Rubinstein, Nimrod D, Groff, Abigail F, Liapis, Steve C, Gerhardinger, Chiara, Bester, Assaf, Pandolfi, Pier Paolo, Clohessy, John G, Hoekstra, Hopi E, Sauvageau, Martin, Rinn, John L

“…Several long noncoding RNAs (lncRNAs) have been shown to function as components of molecular machines that play fundamental roles in biology. While the number…”
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Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain by Goff, Loyal A., Groff, Abigail F., Sauvageau, Martin, Trayes-Gibson, Zachary, Sanchez-Gomez, Diana B., Morse, Michael, Martin, Ryan D., Elcavage, Lara E., Liapis, Stephen C., Gonzalez-Celeiro, Meryem, Plana, Olivia, Li, Eric, Gerhardinger, Chiara, Tomassy, Giulio S., Arlotta, Paola, Rinn, John L.

“…Long noncoding RNAs (lncRNAs) have been implicated in numerous cellular processes including brain development. However, the in vivo expression dynamics and…”
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Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration by Tran, Viviane, Nahlé, Sarah, Robert, Amélie, Desanlis, Inès, Killoran, Ryan, Ehresmann, Sophie, Thibault, Marie-Pier, Barford, David, Ravichandran, Kodi S., Sauvageau, Martin, Smith, Matthew J., Kmita, Marie, Côté, Jean-François

“…Myoblast fusion is fundamental for the development of multinucleated myofibers. Evolutionarily conserved proteins required for myoblast fusion include RAC1 and…”
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In Vivo Characterization of Linc-p21 Reveals Functional cis-Regulatory DNA Elements by Groff, Abigail F., Sanchez-Gomez, Diana B., Soruco, Marcela M.L., Gerhardinger, Chiara, Barutcu, A. Rasim, Li, Eric, Elcavage, Lara, Plana, Olivia, Sanchez, Lluvia V., Lee, James C., Sauvageau, Martin, Rinn, John L.

“…The Linc-p21 locus, encoding a long non-coding RNA, plays an important role in p53 signaling, cell-cycle regulation, and tumor suppression. However, despite…”
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Polycomb group genes: keeping stem cell activity in balance by Sauvageau, Martin, Sauvageau, Guy

“…Abbreviations: ES, embryonic stem; HSC, hematopoietic stem cell; PcG, Polycomb group; PRC, Polycomb Repressive Complex The capacity to undergo self-renewal--to…”
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RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity by Cellot, Sonia, Hope, Kristin J., Chagraoui, Jalila, Sauvageau, Martin, Deneault, Éric, MacRae, Tara, Mayotte, Nadine, Wilhelm, Brian T., Landry, Josette R., Ting, Stephen B., Krosl, Jana, Humphries, Keith, Thompson, Alexander, Sauvageau, Guy

“…Histone methylation is a dynamic and reversible process proposed to directly impact on stem cell fate. The Jumonji (JmjC) domain–containing family of…”
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A Functional Screen to Identify Novel Effectors of Hematopoietic Stem Cell Activity by Deneault, Eric, Cellot, Sonia, Faubert, Amélie, Laverdure, Jean-Philippe, Fréchette, Mélanie, Chagraoui, Jalila, Mayotte, Nadine, Sauvageau, Martin, Ting, Stephen B., Sauvageau, Guy

“…Despite tremendous progress made toward the identification of the molecular circuitry that governs cell fate in embryonic stem cells, genes controlling this…”
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UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity by Bordeleau, Marie-Eve, Aucagne, Romain, Chagraoui, Jalila, Girard, Simon, Mayotte, Nadine, Bonneil, Éric, Thibault, Pierre, Pabst, Caroline, Bergeron, Anne, Barabé, Frédéric, Hébert, Josée, Sauvageau, Martin, Boutonnet, Christel, Meloche, Sylvain, Sauvageau, Guy

“…Multipotent long-term repopulating hematopoietic stem cells (LT-HSCs) can self-renew or differentiate into the less primitive short-term repopulating stem…”
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Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type–specific cancer genes in leukemia by Sauvageau, Martin, Miller, Michelle, Lemieux, Sébastien, Lessard, Julie, Hébert, Josée, Sauvageau, Guy

“…Proviral insertional mutagenesis is a powerful tool for the discovery of cancer-associated genes. The ability of integrated proviruses to affect gene…”
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High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia by Bijl, Janet, Sauvageau, Martin, Thompson, Alexander, Sauvageau, Guy

“…Relevant mouse models of E2a-PBX1-induced pre-B cell leukemia are still elusive. We now report the generation of a pre-B leukemia model using E2a-PBX1…”
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Diverging RNPs: Toward Understanding lncRNA-Protein Interactions and Functions by Sauvageau, Martin

“…RNA-protein interactions are essential to a variety of biological processes. The realization that mammalian genomes are pervasively transcribed brought a tidal…”
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Overexpression of PRDM16 in the presence and absence of the RUNX1/PRDM16 fusion gene in myeloid leukemias by Hazourli, Sawcène, Chagnon, Pierre, Sauvageau, Martin, Fetni, Raouf, Busque, Lambert, Hébert, Josée

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Differential analysis of gene regulation at transcript resolution with RNA-seq by Trapnell, Cole, Hendrickson, David G, Sauvageau, Martin, Goff, Loyal, Rinn, John L, Pachter, Lior

“…The Cuffdiff 2 algorithm improves analysis of RNA-Seq data by accounting for sample-to-sample biological variability and the complexity of transcript isoforms…”
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A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia by Simon, Camille, Chagraoui, Jalila, Krosl, Jana, Gendron, Patrick, Wilhelm, Brian, Lemieux, Sébastien, Boucher, Geneviève, Chagnon, Pierre, Drouin, Simon, Lambert, Raphaëlle, Rondeau, Claude, Bilodeau, Annie, Lavallée, Sylvie, Sauvageau, Martin, Hébert, Josée, Sauvageau, Guy

“…In this study, we show the high frequency of spontaneous γδ T-cell leukemia (T-ALL) occurrence in mice with biallelic deletion of enhancer of zeste homolog 2…”
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A role for GPx3 in activity of normal and leukemia stem cells by Herault, Olivier, Hope, Kristin J, Deneault, Eric, Mayotte, Nadine, Chagraoui, Jalila, Wilhelm, Brian T, Cellot, Sonia, Sauvageau, Martin, Andrade-Navarro, Miguel A, Hébert, Josée, Sauvageau, Guy

“…The determinants of normal and leukemic stem cell self-renewal remain poorly characterized. We report that expression of the reactive oxygen species (ROS)…”
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Corrigendum to “PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease” [Metabolism Volume 150, January 2024, 155736, PMID: 7967646] by Sachan, Vatsal, LeDévéhat, Maïlys, Roubtsova, Anna, Essalmani, Rachid, Laurendeau, Jean-Francois, Garçon, Damien, Susan-Sesiga, Delia, Duval, Stéphanie, Mikaeeli, Sahar, Hamelin, Josée, Evagelidis, Alexandra, Chong, Michael, Paré, Guillaume, Chernetsova, Elizabeta, Gao, Zu-Hua, Robillard, Isabelle, Ruiz, Matthieu, Trinh, Vincent Quoc-Huy, Estall, Jennifer L., Faraj, May, Austin, Richard C., Sauvageau, Martin, Prat, Annik, Kiss, Robert S., Seidah, Nabil G.

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