Search Results - "Sautebin, L."

The 5‐lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages by Rossi, A, Pergola, C, Koeberle, A, Hoffmann, M, Dehm, F, Bramanti, P, Cuzzocrea, S, Werz, O, Sautebin, L

“…BACKGROUND AND PURPOSE Zileuton is the only 5‐lipoxygenase (5‐LOX) inhibitor marketed as a treatment for asthma, and is often utilized as a selective tool to…”
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Inhibition of microsomal prostaglandin E 2 synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense by Siemoneit, U, Koeberle, A, Rossi, A, Dehm, F, Verhoff, M, Reckel, S, Maier, TJ, Jauch, J, Northoff, H, Bernhard, F, Doetsch, V, Sautebin, L, Werz, O

“…BACKGROUND AND PURPOSE Frankincense, the gum resin derived from Boswellia species, showed anti‐inflammatory efficacy in animal models and in pilot clinical…”
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ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma by Pergola, Carlo, Dodt, Gabriele, Rossi, Antonietta, Neunhoeffer, Eva, Lawrenz, Barbara, Northoff, Hinnak, Samuelsson, Bengt, Rådmark, Olof, Sautebin, Lidia, Werz, Oliver

“…5-Lipoxygenase initiates the biosynthesis of leukotrienes, lipid mediators involved in normal host defense and in inflammatory and allergic disorders. Despite…”
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The novel benzimidazole derivative BRP‐7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5‐lipoxygenase‐activating protein (FLAP) by Pergola, C, Gerstmeier, J, Mönch, B, Çalışkan, B, Luderer, S, Weinigel, C, Barz, D, Maczewsky, J, Pace, S, Rossi, A, Sautebin, L, Banoglu, E, Werz, O

“…Background and Purpose Leukotrienes (LTs) are inflammatory mediators produced via the 5‐lipoxygenase (5‐LOX) pathway and are linked to diverse disorders,…”
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On the inhibition of 5‐lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo by Pergola, C, Jazzar, B, Rossi, A, Northoff, H, Hamburger, M, Sautebin, L, Werz, O

“…BACKGROUND AND PURPOSE Leukotrienes (LTs) are pro‐inflammatory mediators produced by 5‐lipoxygenase (5‐LO). Currently available 5‐LO inhibitors either lack…”
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Effects of zileuton and montelukast in mouse experimental spinal cord injury by Genovese, T, Rossi, A, Mazzon, E, Di Paola, R, Muià, C, Caminiti, R, Bramanti, P, Sautebin, L, Cuzzocrea, S

“…Background and purpose: 5‐lipoxygenase (5‐LO) is the key enzyme in leukotriene (LT) biosynthesis from arachidonic acid (AA). Here, we examined the role of the…”
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The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction by Martelli, A., Testai, L., Anzini, M., Cappelli, A., Di Capua, A., Biava, M., Poce, G., Consalvi, S., Giordani, A., Caselli, G., Rovati, L., Ghelardini, C., Patrignani, P., Sautebin, L., Breschi, M.C., Calderone, V.

“…Selective cyclooxygenase 2 (COX2) inhibitors (COXIBs) are effective anti-inflammatory and analgesic drugs with improved gastrointestinal (GI) safety compared…”
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Anti-inflammatory activity of macrolide antibiotics by Ianaro, A, Ialenti, A, Maffia, P, Sautebin, L, Rombolà, L, Carnuccio, R, Iuvone, T, D'Acquisto, F, Di Rosa, M

“…The effect of four macrolide antibiotics (roxithromycin, clarithromycin, erythromycin, and azithromycin) on the generation of some mediators and cytokines…”
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Enlarging the NSAIDs family: ether, ester and acid derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents by Biava, M, Porretta, G C, Poce, G, Battilocchio, C, Botta, M, Manetti, F, Rovini, M, Cappelli, A, Sautebin, L, Rossi, A, Pergola, C, Ghelardini, C, Galeotti, N, Makovec, F, Giordani, A, Anzellotti, P, Tacconelli, S, Patrignani, P, Anzini, M

“…The development of the coxib family has represented a stimulating approach in the treatment of inflammatory disorders, such as arthritis, and for the…”
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2‐(4‐(Biphenyl‐4‐ylamino)‐6‐chloropyrimidin‐2‐ylthio)octanoic acid (HZ52) – a novel type of 5‐lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo by Greiner, C, Hörnig, C, Rossi, A, Pergola, C, Zettl, H, Schubert‐Zsilavecz, M, Steinhilber, D, Sautebin, L, Werz, O

“…BACKGROUND AND PURPOSE 5‐Lipoxygenase (5‐LO) is the key enzyme in the biosynthesis of pro‐inflammatory leukotrienes (LTs) representing a potential target for…”
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The inhibitory effect of propolis and caffeic acid phenethyl ester on cyclooxygenase activity in J774 macrophages by Rossi, A., Ligresti, A., Longo, R., Russo, A., Borrelli, F., Sautebin, L.

“…The effect of an ethanolic extract of propolis, with and without CAPE, and some of its components on cyclooxygenase (COX-1 and COX-2) activity in J774…”
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17beta-estradiol antiinflammatory activity in carrageenan-induced pleurisy by Cuzzocrea, S, Santagati, S, Sautebin, L, Mazzon, E, Calabrò, G, Serraino, I, Caputi, A P, Maggi, A

“…We have recently demonstrated that 17beta-estradiol (E2) opposes cytokine-dependent increase of inducible nitric oxide synthase (iNOS) activity in rat smooth…”
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The protective role of endogenous estrogens in carrageenan-induced lung injury in the rat by Cuzzocrea, S, Mazzon, E, Sautebin, L, Serraino, I, Dugo, L, Calabró, G, Caputi, A P, Maggi, A

“…We have recently demonstrated that 17beta-estradiol (E2) inhibits the increase of inducible nitric oxide synthetase (iNOS) activity in selected model systems…”
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Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774 by Marotta, Principia, Sautebin, Lidia, Rosa, Massimo

“…The effect of eicosanoids on the induction of nitric oxide synthase in the murine macrophage cell line J774 has been studied. We found that prostaglandin E2…”
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Nitric oxide inhibits leucocyte migration in carrageenin-induced rat pleurisy by Ialenti, A, Ianaro, A, Maffia, P, Sautebin, L, Di Rosa, M

“…The role of nitric oxide (NO) on leucocyte migration has been investigated in rat carrageenin-induced pleurisy. Male Wistar rats. L-arginine, NOC-18 and…”
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Relaxant effect of capsazepine in the isolated rat ileum by Nocerino, Emilia, Izzo, Angelo A, Borrelli, Francesca, Capasso, Francesco, Capasso, Raffaele, Pinto, Aldo, Sautebin, Lidia, Mascolo, Nicola

“…We have evaluated the effect of the vanilloid receptor agonists resiniferatoxin (RTX), capsaicin and piperine and of the vanilloid receptor antagonist…”
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Food deprivation increases brain nitric oxide synthase and depresses brain serotonin levels in rats by Squadrito, F, Calapai, G, Altavilla, D, Cucinotta, D, Zingarelli, B, Campo, G M, Arcoraci, V, Sautebin, L, Mazzaglia, G, Caputi, A P

“…We studied nitric oxide (NO) synthase activity and serotonin content in the diencephalon of 24 hr food deprived rats. NO synthase activity was significantly…”
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Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males by Pace, Simona, Pergola, Carlo, Dehm, Friederike, Rossi, Antonietta, Gerstmeier, Jana, Troisi, Fabiana, Pein, Helmut, Schaible, Anja M, Weinigel, Christina, Rummler, Silke, Northoff, Hinnak, Laufer, Stefan, Maier, Thorsten J, Rådmark, Olof, Samuelsson, Bengt, Koeberle, Andreas, Sautebin, Lidia, Werz, Oliver

“…Proinflammatory leukotrienes (LTs) are produced by 5-lipoxygenase (5-LO) aided by 5-LO-activating protein (FLAP). LT biosynthesis inhibitors are currently…”
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Carrageenan‐induced mouse paw oedema is biphasic, age‐weight dependent and displays differential nitric oxide cyclooxygenase‐2 expression by Posadas, Inmaculada, Bucci, Mariarosaria, Roviezzo, Fiorentina, Rossi, Antonietta, Parente, Luca, Sautebin, Lidia, Cirino, Giuseppe

“…Injection of carrageenan 1% (50 μl) in the mouse paw causes a biphasic response: an early inflammatory response that lasts 6 h and a second late response that…”
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In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis by Rossi, Antonietta, Pergola, Carlo, Pace, Simona, Rådmark, Olof, Werz, Oliver, Sautebin, Lidia

“…Leukotrienes (LTs) are 5-lipoxygenase (5-LO) metabolites which are implicated in sex-dependent inflammatory diseases (asthma, autoimmune diseases, etc.). We…”
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