Search Results - "Saurat, Nathalie"

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons by Kishinevsky, Sarah, Wang, Tai, Rodina, Anna, Chung, Sun Young, Xu, Chao, Philip, John, Taldone, Tony, Joshi, Suhasini, Alpaugh, Mary L., Bolaender, Alexander, Gutbier, Simon, Sandhu, Davinder, Fattahi, Faranak, Zimmer, Bastian, Shah, Smit K., Chang, Elizabeth, Inda, Carmen, Koren, John, Saurat, Nathalie G., Leist, Marcel, Gross, Steven S., Seshan, Venkatraman E., Klein, Christine, Tomishima, Mark J., Erdjument-Bromage, Hediye, Neubert, Thomas A., Henrickson, Ronald C., Chiosis, Gabriela, Studer, Lorenz

“…Environmental and genetic risk factors contribute to Parkinson’s Disease (PD) pathogenesis and the associated midbrain dopamine (mDA) neuron loss. Here, we…”
Get full text

Capturing the biology of disease severity in a PSC-based model of familial dysautonomia by Zeltner, Nadja, Fattahi, Faranak, Dubois, Nicole C, Saurat, Nathalie, Lafaille, Fabien, Shang, Lei, Zimmer, Bastian, Tchieu, Jason, Soliman, Mohamed A, Lee, Gabsang, Casanova, Jean-Laurent, Studer, Lorenz

“…Using induced pluripotent stem cells from patients with familial dysautonomia, the authors show that in vitro models can recapitulate patient-specific…”
Get full text

APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons by Moore, Steven, Evans, Lewis D.B., Andersson, Therese, Portelius, Erik, Smith, James, Dias, Tatyana B., Saurat, Nathalie, McGlade, Amelia, Kirwan, Peter, Blennow, Kaj, Hardy, John, Zetterberg, Henrik, Livesey, Frederick J.

“…Accumulation of Aβ peptide fragments of the APP protein and neurofibrillary tangles of the microtubule-associated protein tau are the cellular hallmarks of…”
Get full text

Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease by Guttikonda, Sudha R., Sikkema, Lisa, Tchieu, Jason, Saurat, Nathalie, Walsh, Ryan M., Harschnitz, Oliver, Ciceri, Gabriele, Sneeboer, Marjolein, Mazutis, Linas, Setty, Manu, Zumbo, Paul, Betel, Doron, de Witte, Lot D., Pe’er, Dana, Studer, Lorenz

“…Aberrant inflammation in the CNS has been implicated as a major player in the pathogenesis of human neurodegenerative disease. We developed a new approach to…”
Get full text

Cortical Differentiation of Human Pluripotent Cells for In Vitro Modeling of Alzheimer's Disease by Saurat, Nathalie G, Livesey, Frederick J, Moore, Steven

“…Stem cell models of Alzheimer's disease provide an opportunity to study the mechanisms underlying disease pathology at a resolution that is not possible in…”
Get more information

Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development by Saurat, Nathalie, Andersson, Therese, Vasistha, Navneet A, Molnár, Zoltán, Livesey, Frederick J

“…During cerebral cortex development, multipotent neural progenitor cells generate a variety of neuronal subtypes in a fixed temporal order. How a single neural…”
Get full text

G&T-seq: parallel sequencing of single-cell genomes and transcriptomes by Macaulay, Iain C, Haerty, Wilfried, Kumar, Parveen, Li, Yang I, Hu, Tim Xiaoming, Teng, Mabel J, Goolam, Mubeen, Saurat, Nathalie, Coupland, Paul, Shirley, Lesley M, Smith, Miriam, Van der Aa, Niels, Banerjee, Ruby, Ellis, Peter D, Quail, Michael A, Swerdlow, Harold P, Zernicka-Goetz, Magdalena, Livesey, Frederick J, Ponting, Chris P, Voet, Thierry

“…G&T-seq offers robust full-length transcript and whole-genome sequencing simultaneously from a single cell. The simultaneous sequencing of a single cell's…”
Get full text

Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration by Saurat, Nathalie, Minotti, Andrew P, Rahman, Maliha T, Sikder, Trisha, Zhang, Chao, Cornacchia, Daniela, Jungverdorben, Johannes, Ciceri, Gabriele, Betel, Doron, Studer, Lorenz

“…Aging is the biggest risk factor for the development of Alzheimer's disease (AD). Here, we performed a whole-genome CRISPR screen to identify regulators of…”
Get more information

Developmental chromatin programs determine oncogenic competence in melanoma by Baggiolini, Arianna, Callahan, Scott J, Montal, Emily, Weiss, Joshua M, Trieu, Tuan, Tagore, Mohita M, Tischfield, Sam E, Walsh, Ryan M, Suresh, Shruthy, Fan, Yujie, Campbell, Nathaniel R, Perlee, Sarah C, Saurat, Nathalie, Hunter, Miranda V, Simon-Vermot, Theresa, Huang, Ting-Hsiang, Ma, Yilun, Hollmann, Travis, Tickoo, Satish K, Taylor, Barry S, Khurana, Ekta, Koche, Richard P, Studer, Lorenz, White, Richard M

“…Oncogenes only transform cells under certain cellular contexts, a phenomenon called oncogenic competence. Using a combination of a human pluripotent stem…”
Get full text

Capturing the biology of mild versus severe disease in a pluripotent stem cell-based model of Familial Dysautonomia by Zeltner, Nadja, Fattahi, Faranak, Dubois, Nicole C., Saurat, Nathalie, Lafaille, Fabien, Shang, Lei, Zimmer, Bastian, Tchieu, Jason, Soliman, Mohamed A., Lee, Gabsang, Casanova, Jean-Laurent, Studer, Lorenz

“…Familial Dysautonomia (FD) is a debilitating disorder that affects derivatives of the neural crest (NC). For unknown reasons, FD patients show marked…”
Get full text