Search Results - "Saura, Andreu"

The 29-nucleotide deletion in SARS-CoV: truncated versions of ORF8 are under purifying selection by Bykova, Anastassia, Saura, Andreu, Glazko, Galina V, Roche-Lima, Abiel, Yurchenko, Vyacheslav, Rogozin, Igor B

“…Accessory proteins have diverse roles in coronavirus pathobiology. One of them in SARS-CoV (the causative agent of the severe acute respiratory syndrome…”
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Properties and Mechanisms of Deletions, Insertions, and Substitutions in the Evolutionary History of SARS-CoV-2 by Rogozin, Igor B, Saura, Andreu, Poliakov, Eugenia, Bykova, Anastassia, Roche-Lima, Abiel, Pavlov, Youri I, Yurchenko, Vyacheslav

“…SARS-CoV-2 has accumulated many mutations since its emergence in late 2019. Nucleotide substitutions leading to amino acid replacements constitute the primary…”
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Depolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites by Iribarren, Paula Ana, Di Marzio, Lucía Ayelén, Berazategui, María Agustina, Saura, Andreu, Coria, Lorena, Cassataro, Juliana, Rojas, Federico, Navarro, Miguel, Alvarez, Vanina Eder

“…Trypanosoma brucei are protozoan parasites that cause sleeping sickness in humans and nagana in cattle. Inside the mammalian host, a quorum sensing-like…”
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Phlebotomine sand fly (Diptera: Phlebotominae) diversity in the foci of cutaneous leishmaniasis in the Surxondaryo Region of Uzbekistan: 50 years on by Usarov, Gofur X., Turitsin, Vladimir S., Sattarova, Xulkar G., Sádlová, Jovana, Mustanov, Javokhir Abdusamat ugli, Saura, Andreu, Yurchenko, Vyacheslav

“…In Uzbekistan, the number of reported leishmaniasis cases is rising at the alarming rate. In this work, we studied the phlebotomine sand fly (Diptera:…”
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Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: Phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content by Zakharova, Alexandra, Albanaz, Amanda T S, Opperdoes, Fred R, Škodová-Sveráková, Ingrid, Zagirova, Diana, Saura, Andreu, Chmelová, Lˇubomíra, Gerasimov, Evgeny S, Leštinová, Tereza, Bečvář, Tomáš, Sádlová, Jovana, Volf, Petr, Lukeš, Julius, Horváth, Anton, Butenko, Anzhelika, Yurchenko, Vyacheslav

“…Leishmaniasis is a parasitic vector-borne disease caused by the protistan flagellates of the genus Leishmania. Leishmania (Viannia) guyanensis is one of the…”
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Deletions across the SARS-CoV-2 Genome: Molecular Mechanisms and Putative Functional Consequences of Deletions in Accessory Genes by Rogozin, Igor B, Saura, Andreu, Bykova, Anastassia, Brover, Vyacheslav, Yurchenko, Vyacheslav

“…The analysis of deletions may reveal evolutionary trends and provide new insight into the surprising variability and rapidly spreading capability that…”
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Elimination of LRVs Elicits Different Responses in Leishmania spp by Saura, Andreu, Zakharova, Alexandra, Klocek, Donnamae, Gerasimov, Evgeny S., Butenko, Anzhelika, Macedo, Diego H., Servienė, Elena, Zagirova, Diana, Meshcheryakova, Anastasia, Rogozin, Igor B., Serva, Saulius, Kostygov, Alexei Yu, Yurchenko, Vyacheslav

“…Leishmaniaviruses (LRVs) have been demonstrated to enhance progression of leishmaniasis, a vector-transmitted disease with a wide range of clinical…”
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Catalase impairs Leishmania mexicana development and virulence by Sádlová, Jovana, Podešvová, Lucie, Bečvář, Tomáš, Bianchi, Claretta, Gerasimov, Evgeny S., Saura, Andreu, Glanzová, Kristýna, Leštinová, Tereza, Matveeva, Nadezhda S., Chmelová, Ľubomíra, Mlacovská, Denisa, Spitzová, Tatiana, Vojtková, Barbora, Volf, Petr, Yurchenko, Vyacheslav, Kraeva, Natalya

“…Catalase is one of the most abundant enzymes on Earth. It decomposes hydrogen peroxide, thus protecting cells from dangerous reactive oxygen species. The…”
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DNA Methylation, Deamination, and Translesion Synthesis Combine to Generate Footprint Mutations in Cancer Driver Genes in B-Cell Derived Lymphomas and Other Cancers by Rogozin, Igor B., Roche-Lima, Abiel, Tyryshkin, Kathrin, Carrasquillo-Carrión, Kelvin, Lada, Artem G., Poliakov, Lennard Y., Schwartz, Elena, Saura, Andreu, Yurchenko, Vyacheslav, Cooper, David N., Panchenko, Anna R., Pavlov, Youri I.

“…Cancer genomes harbor numerous genomic alterations and many cancers accumulate thousands of nucleotide sequence variations. A prominent fraction of these…”
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A neo-functionalized homolog of host transmembrane protein controls localization of bacterial endosymbionts in the trypanosomatid Novymonas esmeraldas by Zakharova, Alexandra, Tashyreva, Daria, Butenko, Anzhelika, Morales, Jorge, Saura, Andreu, Svobodová, Michaela, Poschmann, Gereon, Nandipati, Satish, Zakharova, Alena, Noyvert, David, Gahura, Ondřej, Týč, Jiří, Stühler, Kai, Kostygov, Alexei Y., Nowack, Eva C.M., Lukeš, Julius, Yurchenko, Vyacheslav

“…The stability of endosymbiotic associations between eukaryotes and bacteria depends on a reliable mechanism ensuring vertical inheritance of the latter. Here,…”
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Intricate balance of dually-localized catalase modulates infectivity of Leptomonas seymouri (Kinetoplastea: Trypanosomatidae) by Chmelová, Ľubomíra, Kraeva, Natalya, Saura, Andreu, Krayzel, Adam, Vieira, Cecilia Stahl, Ferreira, Tainá Neves, Soares, Rodrigo Pedro, Bučková, Barbora, Galan, Arnau, Horáková, Eva, Vojtková, Barbora, Sádlová, Jovana, Malysheva, Marina N., Butenko, Anzhelika, Prokopchuk, Galina, Frolov, Alexander O., Lukeš, Julius, Horváth, Anton, Škodová-Sveráková, Ingrid, Feder, Denise, Yu. Kostygov, Alexei, Yurchenko, Vyacheslav

“…[Display omitted] •Catalase in Leptomonas seymouri is present in the cytoplasm and a subset of glycosomes.•Cytoplasmic retention of L. seymouri catalase is…”
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Pharmacophore Identification and Structure–Activity Relationship Analysis of a Series of Substituted Azaindoles as Inhibitors of Trypanosoma brucei by Ferrins, Lori, Diaz, Rosario, Cordon-Obras, Carlos, Rojas-Barros, Domingo, Quotadamo, Antonio, Oehme, Daniel P., Ceballos-Pérez, Gloria, Swaminathan, Uma, Pérez-Moreno, Guiomar, Bosch-Navarrete, Cristina, García-Hernández, Raquel, Gomez-Liñan, Claudia, Saura, Andreu, Ruiz-Perez, Luis Miguel, Gamarro, Francisco, Martinez-Martinez, Maria Santos, Manzano, Pilar, González-Pacanowska, Dolores, Navarro, Miguel, Pollastri, Michael P.

“…Human African trypanosomiasis is among the World Health Organization’s designated neglected tropical diseases. Repurposing strategies are often employed in…”
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A New Model Trypanosomatid, Novymonas esmeraldas : Genomic Perception of Its " Candidatus Pandoraea novymonadis" Endosymbiont by Zakharova, Alexandra, Saura, Andreu, Butenko, Anzhelika, Podešvová, Lucie, Warmusová, Sandra, Kostygov, Alexei Yu, Nenarokova, Anna, Lukeš, Julius, Opperdoes, Fred R, Yurchenko, Vyacheslav

“…The closest relative of human pathogen , the trypanosomatid , harbors a bacterial endosymbiont " Pandoraea novymonadis." Based on genomic data, we performed a…”
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SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes by Saura, Andreu, Iribarren, Paula A, Rojas‐Barros, Domingo, Bart, Jean M, López‐Farfán, Diana, Andrés‐León, Eduardo, Vidal‐Cobo, Isabel, Boehm, Cordula, Alvarez, Vanina E, Field, Mark C, Navarro, Miguel

“…SUMOylation is a post‐translational modification that positively regulates monoallelic expression of the trypanosome variant surface glycoprotein (VSG). The…”
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Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis by Klug, Dana M, Mavrogiannaki, Eftychia M, Forbes, Katherine C, Silva, Lisseth, Diaz-Gonzalez, Rosario, Pérez-Moreno, Guiomar, Ceballos-Pérez, Gloria, Garcia-Hernández, Raquel, Bosch-Navarrete, Cristina, Cordón-Obras, Carlos, Gómez-Liñán, Claudia, Saura, Andreu, Momper, Jeremiah D, Martinez-Martinez, Maria Santos, Manzano, Pilar, Syed, Ali, El-Sakkary, Nelly, Caffrey, Conor R, Gamarro, Francisco, Ruiz-Perez, Luis Miguel, Gonzalez Pacanowska, Dolores, Ferrins, Lori, Navarro, Miguel, Pollastri, Michael P

“…Neglected tropical diseases such as human African trypanosomiasis (HAT) are prevalent primarily in tropical climates and among populations living in poverty…”
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A New Model Trypanosomatid, italic toggle="yes">Novymonas esmeraldas /italic>: Genomic Perception of Its “ italic toggle="yes">Candidatus /italic> Pandoraea novymonadis” Endosymbiont by Alexandra Zakharova, Andreu Saura, Anzhelika Butenko, Lucie Podešvová, Sandra Warmusová, Alexei Yu. Kostygov, Anna Nenarokova, Julius Lukeš, Fred R. Opperdoes, Vyacheslav Yurchenko

“…ABSTRACT The closest relative of human pathogen Leishmania, the trypanosomatid Novymonas esmeraldas, harbors a bacterial endosymbiont “Candidatus Pandoraea…”
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Functional and evolutionary analysis of DXL1, a non-essential gene encoding a 1-deoxy-D-xylulose 5-phosphate synthase like protein in Arabidopsis thaliana by Carretero-Paulet, Lorenzo, Cairó, Albert, Talavera, David, Saura, Andreu, Imperial, Santiago, Rodríguez-Concepción, Manuel, Campos, Narciso, Boronat, Albert

“…The synthesis of 1-deoxy-D-xylulose 5-phosphate (DXP), catalyzed by the enzyme DXP synthase (DXS), represents a key regulatory step of the…”
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Effect of viruses on marine stramenopile (MAST) communities in an oligotrophic coastal marine system by Saura, Andreu, Massana, Ramon, Boras, Julia A., Forn, Irene, Vila-Reixach, Gemma, Vaqué, Dolors

“…Viruses are the most abundant biological entities in aquatic systems, infecting from bacteria to mammals. However, there has been little study so far on their…”
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