Induction of endothelial cell migration by proline analogs and its relevance to angiogenesis

The proline analogs cis-4-hydroxy-L-proline, 3,4-dehydro-L-proline, and 2-azetidinecarboxylic acid induced increases in the migration rate of retinal capillary endothelial cells, aortal endothelial cells, corneal endothelial cells, aortal smooth muscle cells, and retinal pericytes. cis-4-hydroxy-D-p...

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Bibliographic Details
Published in:	Experimental cell research Vol. 176; no. 2; p. 248
Main Authors:	McAuslan, B R, Reilly, W, Hannan, G N, Schindhelm, K, Milthorpe, B, Saur, B A
Format:	Journal Article
Language:	English
Published:	United States 01-06-1988
Subjects:	Animals Azetidinecarboxylic Acid - pharmacology Azetines - pharmacology Cattle Cell Division - drug effects Cell Movement - drug effects Cells, Cultured Collagen - biosynthesis Drug Implants Endothelium - drug effects Epidermal Growth Factor - pharmacology Hydroxyproline - pharmacology Neovascularization, Pathologic - chemically induced Procollagen-Proline Dioxygenase - antagonists & inhibitors Proline - analogs & derivatives Proline - pharmacology
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Summary:	The proline analogs cis-4-hydroxy-L-proline, 3,4-dehydro-L-proline, and 2-azetidinecarboxylic acid induced increases in the migration rate of retinal capillary endothelial cells, aortal endothelial cells, corneal endothelial cells, aortal smooth muscle cells, and retinal pericytes. cis-4-hydroxy-D-proline did not. The optimal concentration for migration induction by any of the active agents was approximately 10(-5) M. At higher concentrations (5 x 10(-4) M) migration was not induced or was inhibited. When tested by subcutaneous implant assays in rabbits, cis-4-hydroxy-L-proline and 2-azetidinecarboxylic acid consistently elicited a marked angiogenic response. Whereas these compounds are known to modulate collagen synthesis and secretion, the concentrations at which they are effective inducers of migration suggest that they may have a more specific target than general collagen synthesis.
ISSN:	0014-4827
DOI:	10.1016/0014-4827(88)90328-X