Search Results - "Saunders, William S."

Spindle Multipolarity Is Prevented by Centrosomal Clustering by Quintyne, Nicholas J, Reing, Janet E, Hoffelder, Diane R, Gollin, Susanne M, Saunders, William S

“…Most tumor cells are characterized by increased genomic instability and chromosome segregational defects, often associated with hyperamplification of the…”
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Large-Scale Functional Genomic Analysis of Sporulation and Meiosis in Saccharomyces cerevisiae by Enyenihi, Akon H, Saunders, William S

“…We have used a single-gene deletion mutant bank to identify the genes required for meiosis and sporulation among 4323 nonessential Saccharomyces cerevisiae…”
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DNA repair pathways involved in anaphase bridge formation by Acilan, Ceyda, Potter, Douglas M., Saunders, William S.

“…Cancer cells frequently exhibit gross chromosomal alterations such as translocations, deletions, or gene amplifications an important source of chromosomal…”
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Characterizing the Cellular Response to Nitrogen-Doped Carbon Nanocups by Griffith, Amber S, Zhang, Thomas D, Burkert, Seth C, Adiguzel, Zelal, Acilan, Ceyda, Star, Alexander, Saunders, William S

“…Carbon nanomaterials, specifically, carbon nanotubes (CNTs) have many potential applications in biology and medicine. Currently, this material has not reached…”
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Chromosomal Instability and Cytoskeletal Defects in Oral Cancer Cells by Saunders, William S., Shuster, Michele, Huang, Xin, Gharaibeh, Burhan, Enyenihi, Akon H., Petersen, Iver, Gollin, Susanne M.

“…Oral squamous cell carcinomas are characterized by complex, often near-triploid karyotypes with structural and numerical variations superimposed on the initial…”
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The Role of Molecular Microtubule Motors and the Microtubule Cytoskeleton in Stress Granule Dynamics by Bartoli, Kristen M., Bishop, Darryl L., Saunders, William S.

“…Stress granules (SGs) are cytoplasmic foci that appear in cells exposed to stress-induced translational inhibition. SGs function as a triage center, where…”
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Urban Planning Today: A Harvard Design Magazine Reader by Saunders, William S

“…Urban Planning Today reports on projects in Atlanta, Boston, Chicago, New York, and Portland, bringing perspectives of urban design, city planning, criticism,…”
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Cell division patterns and chromosomal segregation defects in oral cancer stem cells by Kaseb, Hatem O., Lewis, Dale W., Saunders, William S., Gollin, Susanne M.

“…Oral squamous cell carcinoma (OSCC) is a serious public health problem caused primarily by smoking and alcohol consumption or human papillomavirus. The cancer…”
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Targeted inhibition of ATR or CHEK1 reverses radioresistance in oral squamous cell carcinoma cells with distal chromosome arm 11q loss by Sankunny, Madhav, Parikh, Rahul A., Lewis, Dale W., Gooding, William E., Saunders, William S., Gollin, Susanne M.

“…Oral squamous cell carcinoma (OSCC), a subset of head and neck squamous cell carcinoma (HNSCC), is the eighth most common cancer in the U.S.. Amplification of…”
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The FEAR Before MEN: Networks of Mitotic Exit by Dumitrescu, Teodora Pene, Saunders, William S.

“…Variations in the normal regulation of the mitotic cell cycle can lead to such global cellular changes as differential development or malignant transformation…”
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Kinesin molecular motor Eg5 functions during polypeptide synthesis by Bartoli, Kristen M, Jakovljevic, Jelena, Woolford, Jr, John L, Saunders, William S

“…The kinesin-related molecular motor Eg5 plays roles in cell division, promoting spindle assembly. We show that during interphase Eg5 is associated with…”
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A Tale of Too Many Centrosomes by Acilan, Ceyda, Saunders, William S.

“…Having the correct number of centrosomes is crucial for proper chromosome segregation during cell division and for the prevention of aneuploidy, a hallmark of…”
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Overexpression of Cdc20 leads to impairment of the spindle assembly checkpoint and aneuploidization in oral cancer by Mondal, Gourish, Sengupta, Shiladitya, Panda, Chinmoy K., Gollin, Susanne M., Saunders, William S., Roychoudhury, Susanta

“…Defects in the spindle assembly checkpoint are thought to be responsible for an increased rate of aneuploidization during tumorigenesis. Despite a plethora of…”
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Cik1 Targets the Minus-End Kinesin Depolymerase Kar3 to Microtubule Plus Ends by Sproul, Lisa R., Anderson, Daniel J., Mackey, Andrew T., Saunders, William S., Gilbert, Susan P.

“…Kar3, a Saccharomyces cerevisiae Kinesin-14, is essential for karyogamy and meiosis I but also has specific functions during vegetative growth [ 1–7]. For its…”
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Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma by Parikh, Rahul A., White, Jason S., Huang, Xin, Schoppy, David W., Baysal, Bora E., Baskaran, Rajasekaran, Bakkenist, Christopher J., Saunders, William S., Hsu, Lih-Ching, Romkes, Marjorie, Gollin, Susanne M.

“…About 45% of head and neck squamous cell carcinomas (HNSCC) are characterized by amplification of chromosomal band 11q13. This amplification occurs by a…”
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Resolution of anaphase bridges in cancer cells by Hoffelder, Diane R, Luo, Li, Burke, Nancy A, Watkins, Simon C, Gollin, Susanne M, Saunders, William S

“…Chromosomal instability is a key step in the generation of the cancer cell karyotype. An indicator of unstable chromosomes is the presence of chromatin bridges…”
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Widespread Genomic Instability Mediated by a Pathway Involving Glycoprotein Ibα and Aurora B Kinase by Li, Youjun, Xu, Fengfeng L., Lu, Jie, Saunders, William S., Prochownik, Edward V.

“…c-Myc (Myc) oncoprotein induction of genomic instability (GI) contributes to its initial transforming function and subsequent tumor cell evolution. We describe…”
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Relationship between FRA11F and 11q13 gene amplification in oral cancer by Reshmi, Shalini C., Huang, Xin, Schoppy, David W., Black, Robert C., Saunders, William S., Smith, David I., Gollin, Susanne M.

“…Common fragile sites (CFS) are nonstaining gaps or breaks in chromosomes that are expressed under conditions inducing replicative stress. CFS have been…”
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Actin and Microtubules: Working Together to Control Spindle Polarity by Xu, Fengfeng L., Saunders, William S.

“…Centrosomes are frequently amplified in cancer cells, but centrosome clustering pathways act to minimize their detrimental impact on mitosis. Recent data…”
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The c-Myc Target Glycoprotein1bα Links Cytokinesis Failure to Oncogenic Signal Transduction Pathways in Cultured Human Cells by Wu, Qian, Xu, Fengfeng L., Li, Youjun, Prochownik, Edward V., Saunders, William S.

“…An increase in chromosome number, or polyploidization, is associated with a variety of biological changes including breeding of cereal crops and flowers,…”
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