Search Results - "Saunders, Philippa TK"

Single-cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation by Kirkwood, Phoebe M, Gibson, Douglas A, Shaw, Isaac, Dobie, Ross, Kelepouri, Olympia, Henderson, Neil C, Saunders, Philippa T K

“…The human endometrium experiences repetitive cycles of tissue wounding characterised by piecemeal shedding of the surface epithelium and rapid restoration of…”
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Expression of oestrogen receptors, ERα, ERβ, and ERβ variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERα by Collins, Frances, MacPherson, Sheila, Brown, Pamela, Bombail, Vincent, Williams, Alistair RW, Anderson, Richard A, Jabbour, Henry N, Saunders, Philippa TK

“…BACKGROUND: Endometrial cancer is the most common gynaecological malignancy; risk factors include exposure to oestrogens and high body mass index. Expression…”
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Conserved and divergent patterns of expression of DAZL, VASA and OCT4 in the germ cells of the human fetal ovary and testis by Anderson, Richard A, Fulton, Norma, Cowan, Gillian, Coutts, Shona, Saunders, Philippa Tk

“…Germ cells arise from a small group of cells that express markers of pluripotency including OCT4. In humans formation of gonadal compartments (cords in testis,…”
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The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules by Oliveira, Cleida A, Nie, Rong, Carnes, Kay, Franca, Luiz R, Prins, Gail S, Saunders, Philippa T K, Hess, Rex A

“…The antiestrogen ICI 182,780 has been used successfully as an alternative experimental model for the study of estrogen action in the rodent adult male…”
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Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders by Gibson, Douglas A, Simitsidellis, Ioannis, Collins, Frances, Saunders, Philippa T K

“…Peripheral tissue metabolism of steroids (intracrinology) is now accepted as a key way in which tissues, such as the endometrium, can utilise inactive steroids…”
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Estrogen dependent signaling in reproductive tissues – A role for estrogen receptors and estrogen related receptors by Gibson, Douglas A., Saunders, Philippa T.K.

“…► Estrogens regulate the reproductive and cardiovascular systems, the skeleton and the brain. ► Estrogen receptor (ERα, β) genes are subject to alternative…”
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The importance of the macrophage within the human endometrium by Thiruchelvam, Uma, Dransfield, Ian, Saunders, Philippa T. K., Critchley, Hilary O. D.

“…Review on the regulation, phenotype, and role of the macrophage within the endometrium during the menstrual cycle. The human endometrium is exposed to cyclical…”
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Androgens regulate scarless repair of the endometrial “wound” in a mouse model of menstruation by Cousins, Fiona L., Kirkwood, Phoebe M., Murray, Alison A., Collins, Frances, Gibson, Douglas A., Saunders, Philippa T. K.

“…ABSTRACT The human endometrium undergoes regular cycles of synchronous tissue shedding (wounding) and repair that occur during menstruation before…”
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Relevant human tissue resources and laboratory models for use in endometriosis research by Greaves, Erin, Critchley, Hilary O D, Horne, Andrew W, Saunders, Philippa T K

“…Endometriosis is characterized by the growth of endometrium-like tissue outside the uterus, most commonly on the pelvic peritoneum and ovaries. Although it may…”
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Androgen Receptor Expression in the Caput Epididymal Epithelium Is Essential for Development of the Initial Segment and Epididymal Spermatozoa Transit by O'Hara, Laura, Welsh, Michelle, Saunders, Philippa T.K, Smith, Lee B

“…Ablation of androgen receptor in caput epididymal epithelium impairs normal epithelial differentiation and causes obstructive azoospermia. The epididymis plays…”
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Cortisol regulates the paracrine action of macrophages by inducing vasoactive gene expression in endometrial cells by Thiruchelvam, Uma, Maybin, Jacqueline A., Armstrong, Gregory M., Greaves, Erin, Saunders, Philippa T. K., Critchley, Hilary O. D.

“…Cortisol regulation of macrophages induces angiogenic gene expression in endometrial cells at menstruation. The human endometrium undergoes inflammation and…”
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Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential by Mitchell, Rod T, E Camacho-Moll, Maria, Macdonald, Joni, Anderson, Richard A, Kelnar, Christopher J H, O'Donnell, Marie, Sharpe, Richard M, Smith, Lee B, Grigor, Ken M, Wallace, W Hamish B, Stoop, Hans, Wolffenbuttel, Katja P, Donat, Roland, Saunders, Philippa TK, Looijenga, Leendert HJ

“…Testicular germ cell cancer develops from premalignant intratubular germ cell neoplasia, unclassified cells that are believed to arise from failure of normal…”
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The Role of Androgens in Sertoli Cell Proliferation and Functional Maturation: Studies in Mice with Total or Sertoli Cell-Selective Ablation of the Androgen Receptor by Tan, Karen A. L, De Gendt, Karel, Atanassova, Nina, Walker, Marion, Sharpe, Richard M, Saunders, Philippa T. K, Denolet, Evi, Verhoeven, Guido

“…The role of androgens in the proliferation and maturation of Sertoli cells (SC) and the development of their capacity to support spermatogenesis remains poorly…”
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A role for selective androgen response elements in the development of the epididymis and the androgen control of the 5α reductase II gene by Kerkhofs, Stefanie, Dubois, Vanessa, De Gendt, Karel, Helsen, Christine, Clinckemalie, Liesbeth, Spans, Lien, Schuit, Frans, Boonen, Steven, Vanderschueren, Dirk, Saunders, Philippa T. K., Verhoeven, Guido, Claessens, Frank

“…The androgen receptor (AR) recognizes two types of DNA elements that are dimers of 5′‐AGAACA‐3′‐like hexamers, either organized as inverted or direct repeats…”
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Loss of Androgen Receptor Binding to Selective Androgen Response Elements Causes a Reproductive Phenotype in a Knockin Mouse Model by Schauwaers, Kris, De Gendt, Karel, Saunders, Philippa T. K., Atanassova, Nina, Haelens, Annemie, Callewaert, Leen, Moehren, Udo, Swinnen, Johannes V., Verhoeven, Guido, Verrijdt, Guy, Claessens, Frank

“…Androgens influence transcription of their target genes through the activation of the androgen receptor (AR) that subsequently interacts with specific DNA…”
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Androgen action via testicular arteriole smooth muscle cells is important for Leydig cell function, vasomotion and testicular fluid dynamics by Welsh, Michelle, Sharpe, Richard M, Moffat, Lindsey, Atanassova, Nina, Saunders, Philippa T K, Kilter, Sigrid, Bergh, Anders, Smith, Lee B

“…Regulation of blood flow through the testicular microvasculature by vasomotion is thought to be important for normal testis function as it regulates…”
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Do heat stress and deficits in DNA repair pathways have a negative impact on male fertility? by Paul, Catriona, Melton, David W., Saunders, Philippa T.K.

“…In Europe up to one in four couples experience difficulty conceiving and in half of these cases the problem has been attributed to sub or infertility in the…”
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Modulation of ERα transcriptional activity by the orphan nuclear receptor ERRβ and evidence for differential effects of long- and short-form splice variants by Bombail, Vincent, Collins, Frances, Brown, Pamela, Saunders, Philippa T.K.

“…Oestrogen receptor related proteins (ERRs) affect target gene expression without binding oestradiol. We investigated the functional activity of two splice…”
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The Effect of a Sertoli Cell-Selective Knockout of the Androgen Receptor on Testicular Gene Expression in Prepubertal Mice by Denolet, Evi, De Gendt, Karel, Allemeersch, Joke, Engelen, Kristof, Marchal, Kathleen, Van Hummelen, Paul, Tan, Karen A. L, Sharpe, Richard M, Saunders, Philippa T. K, Swinnen, Johannes V, Verhoeven, Guido

“…To unravel the molecular mechanisms mediating the effects of androgens on spermatogenesis, testicular gene expression was compared in mice with Sertoli…”
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A Role for the Orphan Nuclear Receptor Estrogen-Related Receptor α in Endometrial Stromal Cell Decidualization and Expression of Genes Implicated in Energy Metabolism by Bombail, Vincent, Gibson, Douglas A, Collins, Frances, MacPherson, Sheila, Critchley, Hilary O. D, Saunders, Philippa T. K

“…Context: Differentiation (decidualization) of endometrial stromal cells (ESC) is an essential prerequisite for successful implantation and establishment of…”
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