Search Results - "Saunders, Nicholas"

eleanor: An Open-source Tool for Extracting Light Curves from the TESS Full-frame Images by Feinstein, Adina D., Montet, Benjamin T., Foreman-Mackey, Daniel, Bedell, Megan E., Saunders, Nicholas, Bean, Jacob L., Christiansen, Jessie L., Hedges, Christina, Luger, Rodrigo, Scolnic, Daniel, Cardoso, José Vinícius de Miranda

“…During its two-year prime mission, the Transiting Exoplanet Survey Satellite (TESS) will perform a time-series photometric survey covering over 80% of the sky…”
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Progression of Osteosarcoma from a Non-Metastatic to a Metastatic Phenotype Is Causally Associated with Activation of an Autocrine and Paracrine uPA Axis by Endo-Munoz, Liliana, Cai, Na, Cumming, Andrew, Macklin, Rebecca, Merida de Long, Lilia, Topkas, Eleni, Mukhopadhyay, Pamela, Hill, Michelle, Saunders, Nicholas A

“…Pulmonary metastasis is the major untreatable complication of osteosarcoma (OS) resulting in 10-20% long-term survival. The factors and pathways regulating…”
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The role of osteoclasts and tumour-associated macrophages in osteosarcoma metastasis by Endo-Munoz, Liliana, Evdokiou, Andreas, Saunders, Nicholas A.

“…Osteosarcoma (OS) is the most common primary bone tumour in the paediatric age group. Treatment-refractory pulmonary metastasis continues to be the major…”
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Role of intratumoural heterogeneity in cancer drug resistance: molecular and clinical perspectives by Saunders, Nicholas A., Simpson, Fiona, Thompson, Erik W., Hill, Michelle M., Endo‐Munoz, Liliana, Leggatt, Graham, Minchin, Rodney F., Guminski, Alexander

“…Drug resistance continues to be a major barrier to the delivery of curative therapies in cancer. Historically, drug resistance has been associated with…”
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Forged in Conflict: Francis Buckley, the First World War, and British Prehistory by Griffiths, Seren, Saunders, Nicholas J.

“…Francis Buckley was extraordinary; an officer responsible for arming grenades, excavating trenches, surveying, sketch-mapping, and military intelligence, his…”
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Sustained expression of HPV16 E7 oncoprotein promotes p-AKT(Ser473)/p-Src(Tyr527) signaling to drive precancerous lesions to invasive cervical cancer by Lin, Zhongmin, Zhao, Yu, Li, Qijia, Ci, Xingyuan, Ye, Xiaoxian, Chen, Guorong, Tu, Quanmei, Feng, Weixu, Jiang, Pengfei, Zhu, Shanli, Xue, Xiangyang, Saunders, Nicholas A, Zhang, Lifang, Zhu, Xueqiong, Zhao, Kong-Nan

“…Human papillomavirus (HPV) E7 oncogene plays the most important role in cervical cancer. However, whether E7 oncoprotein is continuously expressed, associated…”
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Stellar Cruise Control: Weakened Magnetic Braking Leads to Sustained Rapid Rotation of Old Stars by Saunders, Nicholas, van Saders, Jennifer L., Lyttle, Alexander J., Metcalfe, Travis S., Li, Tanda, Davies, Guy R., Hall, Oliver J., Ball, Warrick H., Townsend, Richard, Creevey, Orlagh, Dodds, Curt

“…Abstract Despite a growing sample of precisely measured stellar rotation periods and ages, the strength of magnetic braking and the degree of departure from…”
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Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas by Saenz-Ponce, Natalia, Pillay, Rachael, de Long, Lilia Merida, Kashyap, Trinayan, Argueta, Christian, Landesman, Yosef, Hazar-Rethinam, Mehlika, Boros, Samuel, Panizza, Benedict, Jacquemyn, Maarten, Daelemans, Dirk, Gannon, Orla M, Saunders, Nicholas A

“…Patient mortality rates have remained stubbornly high (40%) for the past 35 years in head and neck squamous cell carcinoma (HNSCC) due to inherent or acquired…”
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The Far Side of the Galactic Bar/Bulge Revealed through Semi-regular Variables by Hey, Daniel R., Huber, Daniel, Shappee, Benjamin J., Bland-Hawthorn, Joss, Tepper-García, Thor, Sanderson, Robyn, Chakrabarti, Sukanya, Saunders, Nicholas, Hunt, Jason A. S., Bedding, Timothy R., Tonry, John

“…Abstract The Galactic bulge is critical to our understanding of the Milky Way. However, due to the lack of reliable stellar distances, the structure and…”
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Identifying an obinutuzumab resistant subpopulation of monocyte-derived-macrophages from patients with CLL by Burgess, Melinda, Chen, Yu Chen Enya, Mapp, Sally, Mollee, Peter, Gill, Devinder, Saunders, Nicholas A.

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DUX4 Is Derepressed in Late-Differentiating Keratinocytes in Conjunction with Loss of H3K9me3 Epigenetic Repression by Gannon, Orla M., Merida de Long, Lilia, Saunders, Nicholas A.

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TESS Asteroseismology of β Hydri: A Subgiant with a Born-again Dynamo by Metcalfe, Travis S., van Saders, Jennifer L., Huber, Daniel, Buzasi, Derek, García, Rafael A., Stassun, Keivan G., Basu, Sarbani, Breton, Sylvain N., Claytor, Zachary R., Corsaro, Enrico, Nielsen, Martin B., Ong, J. M. Joel, Saunders, Nicholas, Stokholm, Amalie, Bedding, Timothy R.

“…Abstract The solar-type subgiant β Hyi has long been studied as an old analog of the Sun. Although the rotation period has never been measured directly, it was…”
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PI3K-p110δ contributes to antibody responses by macrophages in chronic lymphocytic leukemia by Enya Chen, Yu-Chen, Burgess, Melinda, Mapp, Sally, Mollee, Peter, Gill, Devinder, Blumenthal, Antje, Saunders, Nicholas A.

“…Fcγ receptor (FcγR) signalling in monocyte derived macrophages from chronic lymphocytic leukaemia (CLL) patients is poorly understood. This signalling pathway…”
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Zeitgeist archaeology: conflict, identity and ideology at Prague Castle, 1918–2018 by Saunders, Nicholas J, Frolik, Jan, Heyd, Volker

“…Abstract The discovery of a tenth-century AD high-status burial at Prague Castle in 1928 led to multiple identifications in the context of two world wars and…”
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TESS Giants Transiting Giants. IV. A Low-density Hot Neptune Orbiting a Red Giant Star by Grunblatt, Samuel K., Saunders, Nicholas, Huber, Daniel, Thorngren, Daniel, Vissapragada, Shreyas, Yoshida, Stephanie, Schlaufman, Kevin C., Giacalone, Steven, Macdougall, Mason, Chontos, Ashley, Turtelboom, Emma, Beard, Corey, Murphy, Joseph M. Akana, Rice, Malena, Isaacson, Howard, Angus, Ruth, Howard, Andrew W.

“…Hot Neptunes, gaseous planets smaller than Saturn (∼3–8 R⊕) with orbital periods less than 10 days, are rare. Models predict this is due to high-energy stellar…”
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SIRPα Suppresses Response to Therapeutic Antibodies by Nurse Like Cells From Chronic Lymphocytic Leukemia Patients by Chen, Yu-Chen Enya, Burgess, Melinda, Mapp, Sally, Mollee, Peter, Gill, Devinder, Blumenthal, Antje, Saunders, Nicholas A

“…Targeted antibody therapies improve outcomes for chronic lymphocytic leukemia (CLL) patients. However, resistance often develops. We have previously shown that…”
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An Ex Vivo Human Tumor Assay Shows Distinct Patterns of EGFR Trafficking in Squamous Cell Carcinoma Correlating to Therapeutic Outcomes by Joseph, Shannon R., Gaffney, Daniel, Barry, Rachael, Hu, Lingbo, Banushi, Blerida, Wells, James W., Lambie, Duncan, Strutton, Geoffrey, Porceddu, Sandro V., Burmeister, Bryan, Leggatt, Graham R., Schaider, Helmut, Dolcetti, Riccardo, Frazer, Ian H., Saunders, Nicholas A., Foote, Matthew, Soyer, H. Peter, Simpson, Fiona

“…EGFR overexpression is associated with squamous cell carcinoma development. Altered endocytosis and polarization of receptor tyrosine kinases, including EGFR,…”
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TESS Giants Transiting Giants. III. An Eccentric Warm Jupiter Supports a Period−Eccentricity Relation for Giant Planets Transiting Evolved Stars by Grunblatt, Samuel K., Saunders, Nicholas, Chontos, Ashley, Hattori, Soichiro, Veras, Dimitri, Huber, Daniel, Angus, Ruth, Rice, Malena, Breivik, Katelyn, Blunt, Sarah, Giacalone, Steven, Lubin, Jack, Isaacson, Howard, Howard, Andrew W., Ciardi, David R., Safonov, Boris S., Strakhov, Ivan A., Latham, David W., Bieryla, Allyson, Ricker, George R., Jenkins, Jon M., Tenenbaum, Peter, Shporer, Avi, Morgan, Edward H., Kostov, Veselin, Osborn, Hugh P., Dragomir, Diana, Seager, Sara, Vanderspek, Roland K., Winn, Joshua N.

“…Abstract The fate of planets around rapidly evolving stars is not well understood. Previous studies have suggested that, relative to the main-sequence…”
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Extracellular vesicles secreted by highly metastatic clonal variants of osteosarcoma preferentially localize to the lungs and induce metastatic behaviour in poorly metastatic clones by Macklin, Rebecca, Wang, Haolu, Loo, Dorothy, Martin, Sally, Cumming, Andrew, Cai, Na, Lane, Rebecca, Ponce, Natalia Saenz, Topkas, Eleni, Inder, Kerry, Saunders, Nicholas A, Endo-Munoz, Liliana

“…Osteosarcoma (OS) is the most common pediatric bone tumor and is associated with the emergence of pulmonary metastasis. Unfortunately, the mechanistic basis…”
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Dysregulation of the Repressive H3K27 Trimethylation Mark in Head and Neck Squamous Cell Carcinoma Contributes to Dysregulated Squamous Differentiation by GANNON, Orla M, DE LONG, Lilia Merida, ENDO-MUNOZ, Liliana, HAZAR-RETHINAM, Mehlika, SAUNDERS, Nicholas A

“…Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent cancers diagnosed worldwide and is associated with a 5-year survival rate of 55%…”
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