Search Results - "Saunders, Jesse"

Characterization of the Impaired Glucose Homeostasis Produced in C57BL/6 Mice by Chronic Exposure to Arsenic and High-Fat Diet by Paul, David S., Walton, Felecia S., Saunders, R. Jesse, Stýblo, Miroslav

“…Background: Type 2 diabetes is characterized by glucose intolerance and insulin resistance. Obesity is the leading cause of type 2 diabetes. Growing evidence…”
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Chronic Exposure to Arsenic and Markers of Cardiometabolic Risk: A Cross-Sectional Study in Chihuahua, Mexico by Mendez, Michelle A, González-Horta, Carmen, Sánchez-Ramírez, Blanca, Ballinas-Casarrubias, Lourdes, Cerón, Roberto Hernández, Morales, Damián Viniegra, Terrazas, Francisco A Baeza, Ishida, María C, Gutiérrez-Torres, Daniela S, Saunders, R Jesse, Drobná, Zuzana, Fry, Rebecca C, Buse, John B, Loomis, Dana, García-Vargas, Gonzalo G, Del Razo, Luz M, Stýblo, Miroslav

“…Exposure to arsenic (As) concentrations in drinking water > 150 μg/L has been associated with risk of diabetes and cardiovascular disease, but little is known…”
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Metabolomic characteristics of arsenic-associated diabetes in a prospective cohort in Chihuahua, Mexico by Martin, Elizabeth, González-Horta, Carmen, Rager, Julia, Bailey, Kathryn A, Sánchez-Ramírez, Blanca, Ballinas-Casarrubias, Lourdes, Ishida, María C, Gutiérrez-Torres, Daniela S, Hernández Cerón, Roberto, Viniegra Morales, Damián, Baeza Terrazas, Francisco A, Saunders, R Jesse, Drobná, Zuzana, Mendez, Michelle A, Buse, John B, Loomis, Dana, Jia, Wei, García-Vargas, Gonzalo G, Del Razo, Luz M, Stýblo, Miroslav, Fry, Rebecca

“…Chronic exposure to inorganic arsenic (iAs) has been linked to an increased risk of diabetes, yet the specific disease phenotype and underlying mechanisms are…”
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A concurrent exposure to arsenic and fluoride from drinking water in Chihuahua, Mexico by González-Horta, Carmen, Ballinas-Casarrubias, Lourdes, Sánchez-Ramírez, Blanca, Ishida, María C, Barrera-Hernández, Angel, Gutiérrez-Torres, Daniela, Zacarias, Olga L, Saunders, R Jesse, Drobná, Zuzana, Mendez, Michelle A, García-Vargas, Gonzalo, Loomis, Dana, Stýblo, Miroslav, Del Razo, Luz M

“…Inorganic arsenic (iAs) and fluoride (F-) are naturally occurring drinking water contaminants. However, co-exposure to these contaminants and its effects on…”
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Methylation of arsenic by recombinant human wild-type arsenic (+3 oxidation state) methyltransferase and its methionine 287 threonine (M287T) polymorph: Role of glutathione by Ding, Lan, Saunders, R. Jesse, Drobná, Zuzana, Walton, Felecia S., Xun, Pencheng, Thomas, David J., Stýblo, Miroslav

“…Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the pathway for methylation of arsenicals. A common polymorphism in the AS3MT gene…”
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Associations between arsenic species in exfoliated urothelial cells and prevalence of diabetes among residents of Chihuahua, Mexico by Currier, Jenna M, Ishida, María C, González-Horta, Carmen, Sánchez-Ramírez, Blanca, Ballinas-Casarrubias, Lourdes, Gutiérrez-Torres, Daniela S, Cerón, Roberto Hernández, Morales, Damián Viniegra, Terrazas, Francisco A Baeza, Del Razo, Luz M, García-Vargas, Gonzalo G, Saunders, R Jesse, Drobná, Zuzana, Fry, Rebecca C, Matoušek, Tomáš, Buse, John B, Mendez, Michelle A, Loomis, Dana, Stýblo, Miroslav

“…A growing number of studies link chronic exposure to inorganic arsenic (iAs) with the risk of diabetes. Many of these studies assessed iAs exposure by…”
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Arsenic (+ 3 oxidation state) methyltransferase genotype affects steady-state distribution and clearance of arsenic in arsenate-treated mice by Hughes, Michael F., Edwards, Brenda C., Herbin-Davis, Karen M., Saunders, Jesse, Styblo, Miroslav, Thomas, David J.

“…Arsenic (+ 3 oxidation state) methyltransferase ( As3mt) catalyzes formation of mono-, di-, and tri-methylated metabolites of inorganic arsenic. Distribution…”
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Spatiotemporal-social association predicts immunological similarity in rewilded mice by Downie, Alexander E, Oyesola, Oyebola, Barre, Ramya S, Caudron, Quentin, Chen, Ying-Han, Dennis, Emily J, Garnier, Romain, Kiwanuka, Kasalina, Menezes, Arthur, Navarrete, Daniel J, Mondragón-Palomino, Octavio, Saunders, Jesse B, Tokita, Christopher K, Zaldana, Kimberly, Cadwell, Ken, Loke, P'ng, Graham, Andrea L

“…Environmental influences on immune phenotypes are well-documented, but our understanding of which elements of the environment affect immune systems, and how,…”
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Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure by Douillet, Christelle, Huang, Madelyn C., Saunders, R. Jesse, Dover, Ellen N., Zhang, Chongben, Stýblo, Miroslav

“…Susceptibility to toxic effects of inorganic arsenic (iAs) depends, in part, on efficiency of iAs methylation by arsenic (+3 oxidation state) methyltransferase…”
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Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure by Huang, Madelyn C., Douillet, Christelle, Su, Mingming, Zhou, Kejun, Wu, Tao, Chen, Wenlian, Galanko, Joseph A., Drobná, Zuzana, Saunders, R. Jesse, Martin, Elizabeth, Fry, Rebecca C., Jia, Wei, Stýblo, Miroslav

“…Arsenic (+3 oxidation state) methyltransferase (As3mt) is the key enzyme in the pathway for methylation of inorganic arsenic (iAs). Altered As3mt expression…”
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Association Between Variants in Arsenic (+3 Oxidation State) Methyltranserase (AS3MT) and Urinary Metabolites of Inorganic Arsenic: Role of Exposure Level by Xu, Xiaofan, Drobná, Zuzana, Voruganti, V Saroja, Barron, Keri, González-Horta, Carmen, Sánchez-Ramírez, Blanca, Ballinas-Casarrubias, Lourdes, Cerón, Roberto Hernández, Morales, Damián Viniegra, Terrazas, Francisco A Baeza, Ishida, María C, Gutiérrez-Torres, Daniela S, Saunders, R Jesse, Crandell, Jamie, Fry, Rebecca C, Loomis, Dana, García-Vargas, Gonzalo G, Del Razo, Luz M, Stýblo, Miroslav, Mendez, Michelle A

“…Variants in AS3MT, the gene encoding arsenic (+3 oxidation state) methyltranserase, have been shown to influence patterns of inorganic arsenic (iAs)…”
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Methylated trivalent arsenicals are potent inhibitors of glucose stimulated insulin secretion by murine pancreatic islets by Douillet, Christelle, Currier, Jenna, Saunders, Jesse, Bodnar, Wanda M., Matoušek, Tomáš, Stýblo, Miroslav

“…Epidemiologic evidence has linked chronic exposure to inorganic arsenic (iAs) with an increased prevalence of diabetes mellitus. Laboratory studies have…”
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The pharmacokinetics of therapeutic arsenic trioxide in acute promyelocytic leukemia patients by Ghiuzeli, Cristina M., Stýblo, Miroslav, Saunders, Jesse, Calabro, Anthony, Budman, Daniel, Allen, Steven, Devoe, Craig, Dhingra, Radhika

“…Arsenic trioxide (ATO) treats Acute Promyelocytic Leukemia (APL). ATO is converted from inorganic arsenic (iAs) to methylated (MAs) and dimethylated (DMAs)…”
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Abstract 5053: Arsenic trioxide metabolism in patients with acute promyelocytic leukemia by Khan, Mohammad T., Tariq, Sara, Ghiuzeli, Cristina M., Styblo, Miroslav, Saunders, Jesse, Calabro, Anthony, Kohn, Nina, Budman, Daniel, Allen, Steven, Devoe, Craig

“…BACKGROUND: Arsenic trioxide (ATO) is a mainstay of therapy for Acute Promyelocytic Leukemia (APL). Its long term effects and pharmacokinetics have not been…”
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The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic by Tsang, Verne, Fry, Rebecca C., Niculescu, Mihai D., Rager, Julia E., Saunders, Jesse, Paul, David S., Zeisel, Steven H., Waalkes, Michael P., Stýblo, Miroslav, Drobná, Zuzana

“…Inorganic arsenic (iAs) is a complete transplacental carcinogen in mice. Previous studies have demonstrated that in utero exposure to iAs promotes cancer in…”
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Phase I and pharmacokinetic trial of the antitemolerase agent KML001 (KML) and cisplatin (CDDP) in advanced solid tumors by Edelman, Martin J., Feliciano, Josephine Louella, Styblo, Miroslav, Liu, Tao, Lapidus, Rena G., Saunders, Jesse, Gobburu, Joga

“…Abstract only 2515 Background: Telomerase is overexpressed in most solid tumors and rarely expressed in adult tissues and is therefore a promising target. We…”
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B‐vitamins influence arsenic metabolism in Mexico by Mendez, Michelle A, Vavolizza, Rick, Gonzalez‐Horta, María C., Saunders, Jesse, Gutiérrez‐Torres, Daniela, Ballinas Casarrubias, María de L., Sánchez‐Ramírez, Blanca E., Ishida, María C., Del Razo, Luz M., García‐Vargas, Gonzalo, Drobná, Zuzana, Buse, John, Loomis, Dana, Styblo, Miroslav

“…Abstract only Little is known about dietary modifiers of health risks from environmental contaminants. Inorganic arsenic (iAs), known to increase risk of…”
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Arsenic trioxide: Pharmacokinetics in acute promyelocytic leukemia (APL) patients by Ghiuzeli, Cristina Maria, Calabro, Anthony, Saunders, Randall Jesse, Budman, Daniel R., Styblo, Miroslav, Devoe, Craig E., Allen, Steven L.

“…Abstract only 7055 Background: Arsenic (As) has significantly increased survival for APL patients. As and its metabolites’ effects on cell proliferation,…”
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Chronic Exposure to Arsenic and Markers of Cardiometabolic Risk: A Cross-Sectional Study in Chihuahua, Mexico by Mendez, Michelle A, González-Horta, Carmen, Sánchez-Ramírez, Blanca, Ballinas-Casarrubias, Lourdes, Roberto Hernández Cerón, Damián Viniegra Morales, Baeza Terrazas, Francisco A, Ishida, María C, Gutiérrez-Torres, Daniela S, Saunders, R Jesse

“…Background: Exposure to arsenic (As) concentrations in drinking water > 150 μg/L has been associated with risk of diabetes and cardiovascular disease, but…”
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