Search Results - "Saunders, Harmony"
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Site-specific O-GlcNAcylation of progesterone receptor (PR) supports PR attenuation of interferon stimulated genes (ISGs) and tumor growth in breast cancer
Published in The Journal of biological chemistry (01-11-2024)“…Hormone receptor positive (HR+) breast cancer, defined by expression of estrogen receptor (ER) and/or progesterone receptor (PR), is the most commonly…”
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Growing and dividing: how O-GlcNAcylation leads the way
Published in The Journal of biological chemistry (01-11-2023)“…Cell cycle errors can lead to mutations, chromosomal instability, or death; thus, the precise control of cell cycle progression is essential for viability. The…”
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Elevated O-GlcNAcylation enhances pro-inflammatory Th17 function by altering the intracellular lipid microenvironment
Published in The Journal of biological chemistry (31-05-2019)“…Chronic, low-grade inflammation increases the risk for atherosclerosis, cancer, and autoimmunity in diseases such as obesity and diabetes. Levels of CD4+ T…”
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Abstract 3844: COL11A1: A driver of tumor progression and immune evasion in head and neck squamous cell carcinoma (HNSCC)
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…We previously reported that collagen type XI alpha 1 (COL11A1) is upregulated in head and neck squamous cell carcinoma (HNSCC) and contributes to tumor…”
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Abstract 6571: O-GlcNAc sites on progesterone receptor are critical for its ligand independent repression of interferon signaling in breast cancer
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…The role of hormone receptors in breast cancer has been well established as a key contributor to breast cancer tumorigenesis. Estrogen receptor and…”
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Abstract 5280: O-GlcNAcylation of progesterone receptor promotes mammary tumorigenesis
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…The role of hormone receptors in breast cancer has been well established as a key contributor to breast cancer tumorigenesis. Estrogen receptor and…”
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Abstract 6877: Progesterone promotes immunosuppression in the murine mammary gland by causing T cell death
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Breast Cancer is the most common cancer diagnosed in women in the United States. Second only to lung cancer, breast cancer results in the greatest number of…”
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Abstract 5364: Progesterone receptor modulates the antigen processing and presentation machinery decreasing MHC class I expression on tumors
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Hormone receptor (HR) positive breast cancers, which account for approximately 75% of all breast cancers and express both estrogen receptor (ER) and…”
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Abstract C009: MK2 knockout and radiation enhances immune cell influx in a mouse model of HPV+ head and neck squamous cell carcinoma
Published in Cancer research (Chicago, Ill.) (17-11-2024)“…Introduction: HPV mediated head and neck squamous cell carcinoma (HNSCC) has an immunosuppressive microenvironment which contributes to local and distant…”
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Abstract 2419: Understanding the role of DCLK1 mediated invadopodia regulation in HNSCC
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Despite therapeutic advances, head and neck squamous cell carcinoma (HNSCC) is marked by high mortality, particularly with increasing stage. Locoregional…”
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1109 Progesterone impacts the growth and immune cell infiltration of murine mammary gland tumors
Published in Journal for immunotherapy of cancer (01-11-2022)“…BackgroundClinical studies have linked usage of progestins (synthetic progesterone) to breast cancer risk. However, little is understood regarding the role of…”
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Abstract A78: The role of tumor microenvironment in prostate cancer of African Americans
Published in Cancer epidemiology, biomarkers & prevention (01-10-2015)“…Background: The incidence of prostate cancer (PCa) is approximately 60% higher and the mortality rate 2 to 3 times greater among African American men (AA) in…”
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The Impact of Estrogen on Antigen Presentation and the Racial Disparity in Prostate Cancer
Published 01-01-2017“…Prostate cancer (PCa) is one of the leading causes of cancer related death in men in the US. Unfortunately, African Americans (AA) have higher incidence (1.6X)…”
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Dissertation