Search Results - "Saunders, Colleen"

Defining the molecular signatures of Achilles tendinopathy and anterior cruciate ligament ruptures: A whole-exome sequencing approach by Gibbon, Andrea, Saunders, Colleen J, Collins, Malcolm, Gamieldien, Junaid, September, Alison V

“…Musculoskeletal soft tissue injuries are complex phenotypes with genetics being one of many proposed risk factors. Case-control association studies using the…”
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Factors which affect the application and implementation of a spinal motion restriction protocol by prehospital providers in a low resource setting: A scoping review by Geduld, Charlene, Muller, Henra, Saunders, Colleen J

“…IntroductionThe safety and effectiveness of prehospital clinical c-spine clearance or spinal motion restriction (SMR) decision support tools are unclear. The…”
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Determining the research priorities for emergency care within the Western Cape province of South Africa: A consensus study by Holliman, Robert, Wallis, Lee, Saunders, Colleen

“…Low- and middle-income countries (LMICs) are disproportionally affected by conditions requiring emergency care but there are limited contextually appropriate…”
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Paediatric procedural sedation and analgesia in a South African emergency centre: a single-centre, descriptive study by Dunn, Cornelle, Cloete, Philip, Saunders, Colleen, Evans, Katya

“…Background Procedural sedation and analgesia are considered a core competency in emergency medicine as patients present to the emergency centre on an…”
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Exploring Flood Response Challenges, Training Needs, and the Impact of Online Flood Training for Lifeguards and Water Safety Professionals in South Africa by Peden, Amy E., Mayhew, Adrian, Baker, Shayne D., Mayedwa, Mziwoxolo, Saunders, Colleen J.

“…Flooding is a significant cause of human and economic loss in the African region, including in South Africa. Flood mitigation and response in South Africa is…”
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Semantic interrogation of a multi knowledge domain ontological model of tendinopathy identifies four strong candidate risk genes by Saunders, Colleen J., Jalali Sefid Dashti, Mahjoubeh, Gamieldien, Junaid

“…Tendinopathy is a multifactorial syndrome characterised by tendon pain and thickening and impaired performance during activity. Candidate gene association…”
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The interaction of polymorphisms in extracellular matrix genes and underlying miRNA motifs that modulate susceptibility to anterior cruciate ligament rupture by Willard, Kyle, Mannion, Sasha, Saunders, Colleen J., Collins, Malcolm, September, Alison V.

“…Variants within genes that encode proteins regulating fibrillogenesis such as BGN (rs1126499 C>T, rs1042103 C>T), COL5A1 (rs12722 C>T) and DCN (rs516115 C>T)…”
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The ethical considerations for emergency care research in low- and middle-income countries: A scoping review of the published literature by Hirner, Sarah, Saunders, Colleen, Stassen, Willem

“…Research studies on emergency care in low- and middle-income countries (LMICs) face many ethical considerations, including obtaining valid informed consent…”
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Investigation of variants within the COL27A1 and TNC genes and Achilles tendinopathy in two populations by Saunders, Colleen J., van der Merwe, Lize, Posthumus, Michael, Cook, Jill, Handley, Christopher J., Collins, Malcolm, September, Alison V.

“…The TNC gene has previously been associated with Achilles tendinopathy (AT) in a South African population. The aims of this study were (i) to investigate the…”
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Application of an in silico approach identifies a genetic locus within ITGB2, and its interactions with HSPG2 and FGF9, to be associated with anterior cruciate ligament rupture risk by Dlamini, Senanile B., Saunders, Colleen J., Laguette, Mary-Jessica N., Gibbon, Andrea, Gamieldien, Junaid, Collins, Malcolm, September, Alison V.

“…We developed a Biomedical Knowledge Graph model that is phenotype and biological function-aware through integrating knowledge from multiple domains in a Neo4j,…”
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An analysis of the descriptors of acute myocardial infarction used by South Africans when calling for an ambulance from a private emergency call centre by Buma, Chloe, Saunders, Colleen, Watermeyer, Jennifer, Stassen, Willem

“…Acute myocardial infarction (AMI) is a time sensitive emergency. In resource limited settings, prompt identification and management of patients experiencing…”
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Exploring new genetic variants within COL5A1 intron 4‐exon 5 region and TGF‐β family with risk of anterior cruciate ligament ruptures by Laguette, Mary‐Jessica N., Barrow, Kelly, Firfirey, Firzana, Dlamini, Senanile, Saunders, Colleen J., Dandara, Collet, Gamieldien, Junaid, Collins, Malcolm, September, Alison V.

“…Variants within genes encoding structural and regulatory elements of ligaments have been associated with musculoskeletal soft tissue injury risk. The role of…”
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Extracellular matrix proteins interact with cell-signaling pathways in modifying risk of achilles tendinopathy by Saunders, Colleen J., van der Merwe, Lize, Cook, Jill, Handley, Christopher J., Collins, Malcolm, September, Alison V.

“…ABSTRACT The aim of this study was to investigate interactions between variants within genes encoding components of the collagen fibril and components of…”
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A variant within the AQP1 3ʹ-untranslated region is associated with running performance, but not weight changes, during an Ironman Triathlon by Saunders, Colleen J., Posthumus, Michael, O'Connell, Kevin, September, Alison V., Collins, Malcolm

“…The objective of this study was to test the association of the rs1049305 (G > C) variant within the 3ʹ-untranslated region of the aquaporin 1 gene, AQP1, with…”
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Designing a course model for distance-based online bioinformatics training in Africa: The H3ABioNet experience by Gurwitz, Kim T, Aron, Shaun, Panji, Sumir, Maslamoney, Suresh, Fernandes, Pedro L, Judge, David P, Ghouila, Amel, Domelevo Entfellner, Jean-Baka, Guerfali, Fatma Z, Saunders, Colleen, Mansour Alzohairy, Ahmed, Salifu, Samson P, Ahmed, Rehab, Cloete, Ruben, Kayondo, Jonathan, Ssemwanga, Deogratius, Mulder, Nicola

“…Africa is not unique in its need for basic bioinformatics training for individuals from a diverse range of academic backgrounds. However, particular logistical…”
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Social media and the modern scientist: a research primer for low- and middle-income countries by Dong, Junghwan Kevin, Saunders, Colleen, Wachira, Benjamin W, Thoma, Brent, Chan, Teresa M

“…Social media has changed the way we communicate. Wherever you are in the world, various forms of social media are being used by individuals to share…”
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A COVID-19 field hospital in a conference centre – The Cape Town, South Africa experience by Bulajic, Bojana, Ekambaram, Kamlin, Saunders, Colleen, Naidoo, Vanessa, Wallis, Lee, Amien, Nabeela, Ras, Tasleem, Von Pressentin, Klaus, Tadzimirwa, Gamuchirai, Hussey, Nadia, Reid, Steve, Hodkinson, Peter

“…Background The coronavirus pandemic has put extreme pressure on health care services in South Africa.Aim To describe the design, patients and outcomes of a…”
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Variants within the COMP and THBS2 genes are not associated with Achilles tendinopathy in a case-control study of South African and Australian populations by Saunders, Colleen J., Van Der Merwe, Lize, Cook, Jill, Handley, Christopher J., Collins, Malcolm, September, Alison V.

“…Cartilage oligomeric matrix protein is a structural protein of the extracellular matrix, while thrombospondin-2 is a matricellular protein involved in…”
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The bradykinin β2 receptor (BDKRB2) and endothelial nitric oxide synthase 3 (NOS3) genes and endurance performance during Ironman Triathlons by Saunders, Colleen J., Xenophontos, Stavroulla L., Cariolou, Marios A., Anastassiades, Lakis C., Noakes, Timothy D., Collins, Malcolm

“…We have previously shown that the insertion allele of the angiotensin-converting enzyme (ACE) gene was over-represented in the fastest South-African-born…”
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Dipsogenic genes associated with weight changes during Ironman Triathlons by SAUNDERS, Colleen J, DE MILANDER, Liesl, HEW-BUTLER, Tamara, XENOPHONTOS, Stavroulla L, CARIOLOU, Marios A, ANASTASSIADES, Lakis C, NOAKES, Timothy D, COLLINS, Malcolm

“…Thirst is regulated by a complex interaction of signalling pathways within the central nervous system, including components of the renin-angiotensin and…”
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