Search Results - "Saul, Isabel"

GRADUAL CEREBRAL HYPOPERFUSION INDUCES COGNITIVE IMPAIRMENT FROM NEUROPATHOLOGICAL DEVELOPMENT IN CHOLINERGIC POPULATIONS OF THE MEDIAL SEPTUM by Fagerli, Eric, Saul, Isabel, Perez-Pinzon, Miguel

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Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5 by Morris-Blanco, Kahlilia C., Dave, Kunjan R., Saul, Isabel, Koronowski, Kevin B., Stradecki, Holly M., Perez-Pinzon, Miguel A.

“…Sirtuin 5 (SIRT5) is a mitochondrial-localized NAD + -dependent lysine desuccinylase and a major regulator of the mitochondrial succinylome. We wanted to…”
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POST-CARDIAC ARREST PHYSICAL EXERCISE MITIGATES CHOLINERGIC NEURONAL DEATH IN THE SEPTAL NUCLEI AND RETICULAR THALAMUS by Ferrier, Fernando, Saul, Isabel, Kunjan, Dave, Raval, Ami, Perez-Pinzon, Miguel

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Recurrent Hypoglycemia Exacerbates Cerebral Ischemic Damage in Streptozotocin-Induced Diabetic Rats by DAVE, Kunjan R, TAMARIZ, John, DESAI, Kushal M, BRAND, Frank J, ANNIE LIU, SAUL, Isabel, BHATTACHARYA, Sanjoy K, PILEGGI, Antonello

“…Stroke and heart disease are the most serious complications of diabetes accounting for >65% of mortality among diabetics. Although intensive insulin therapy…”
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Comparing Protection of Remote Limb with Resveratrol Preconditioning following Rodent Subarachnoid Hemorrhage by Koch, Sebastian, De La Rua, Giselle, Farquharson, Donnae, Saul, Isabel, Perez-Pinzon, Miguel, Dave, Kunjan

“…Preventing delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) remains an important therapeutic target. Preconditioning stimulates multiple…”
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Resveratrol Mitigates Cognitive Impairments and Cholinergic Cell Loss in the Medial Septum in a Mouse Model of Gradual Cerebral Hypoperfusion by Fagerli, Eric, Jackson, Charles W, Escobar, Iris, Ferrier, Fernando J, Perez Lao, Efrain J, Saul, Isabel, Gomez, Jorge, Dave, Kunjan R, Bracko, Oliver, Perez-Pinzon, Miguel A

“…Vascular cognitive impairment and dementia (VCID) is the second leading cause of dementia. There is currently no effective treatment for VCID. Resveratrol…”
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Epsilon PKC increases brain mitochondrial SIRT1 protein levels via heat shock protein 90 following ischemic preconditioning in rats by Thompson, John W, Dave, Kunjan R, Saul, Isabel, Narayanan, Srinivasan V, Perez-Pinzon, Miguel A

“…Ischemic preconditioning is a neuroprotective mechanism whereby a sublethal ischemic exposure is protective against a subsequent lethal ischemic attack. We…”
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Remote organ ischemic preconditioning protect brain from ischemic damage following asphyxial cardiac arrest by Dave, Kunjan R., Saul, Isabel, Prado, Ricardo, Busto, Raul, Perez-Pinzon, Miguel A.

“…Ischemic preconditioning (IPC) is a phenomenon whereby an organ's adaptive transient resistance to a lethal ischemic insult occurs by preconditioning this…”
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Sex-Dependent Differences in Physical Exercise-Mediated Cognitive Recovery Following Middle Cerebral Artery Occlusion in Aged Rats by Cohan, Charles H., Youbi, Mehdi, Saul, Isabel, Ruiz, Alex A., Furones, Concepcion C., Patel, Pujan, Perez, Edwin, Raval, Ami P., Dave, Kunjan R., Zhao, Weizhao, Dong, Chuanhui, Rundek, Tatjana, Koch, Sebastian, Sacco, Ralph L., Perez-Pinzon, Miguel A.

“…Stroke remains a leading cause of death and disability in the United States. No current treatments exist to promote cognitive recovery in survivors of stroke…”
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Activation of protein kinase C delta following cerebral ischemia leads to release of cytochrome C from the mitochondria via bad pathway by Dave, Kunjan R, Bhattacharya, Sanjoy K, Saul, Isabel, DeFazio, R Anthony, Dezfulian, Cameron, Lin, Hung Wen, Raval, Ami P, Perez-Pinzon, Miguel A

“…The release of cytochrome c from the mitochondria following cerebral ischemia is a key event leading to cell death. The goal of the present study was to…”
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Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus by Schmidt-Kastner, Rainald, Aguirre-Chen, Cristina, Kietzmann, Thomas, Saul, Isabel, Busto, Raul, Ginsberg, Myron D

“…The 19 kD interacting protein 3, Nip3/BNIP3, is a pro-apoptotic member of the Bcl-2 family induced during hypoxia via the hypoxia-inducible factor (HIF) 1…”
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Astrocytes react to oligemia in the forebrain induced by chronic bilateral common carotid artery occlusion in rats by Schmidt-Kastner, Rainald, Aguirre-Chen, Cristina, Saul, Isabel, Yick, Linda, Hamasaki, Duco, Busto, Raul, Ginsberg, Myron D.

“…The effects of oligemia (moderate ischemia) on the brain need to be explored because of the potential role of subtle microvascular changes in vascular…”
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The effect of high-dose albumin therapy on local cerebral perfusion after transient focal cerebral ischemia in rats by Huh, Pil W, Belayev, Ludmila, Zhao, Weizhao, Busto, Raul, Saul, Isabel, Ginsberg, Myron D

“…We have shown that high-concentration albumin therapy is markedly neuroprotective in focal cerebral ischemia. The present study was conducted to ascertain the…”
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Abstract WP213: The Effect Of Nicotine Withdrawal On Stroke Outcome In Female Rats by Patel, Shahil H, Saul, Isabel, Dave, Kunjan R, Perez-Pinzon, Miguel A, Raval, Ami P

“…SignificanceSmoking-derived nicotine (N) is known to synergistically magnify the risk and severity of cerebral ischemia in females. Most importantly, smoking…”
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Resveratrol Preconditioning Mitigates Ischemia-Induced Septal Cholinergic Cell Loss and Memory Impairments by López-Morales, Mikahela A., Escobar, Iris, Saul, Isabel, Jackson, Charles W., Ferrier, Fernando J., Fagerli, Eric A., Raval, Ami P., Dave, Kunjan R., Perez-Pinzon, Miguel A.

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Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance by Koronowski, Kevin B, Khoury, Nathalie, Saul, Isabel, Loris, Zachary B, Cohan, Charles H, Stradecki-Cohan, Holly M, Dave, Kunjan R, Young, Juan I, Perez-Pinzon, Miguel A

“…BACKGROUND AND PURPOSE—Resveratrol, at least in part via SIRT1 (silent information regulator 2 homologue 1) activation, protects against cerebral ischemia when…”
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Resveratrol Preconditioning Downregulates PARP1 Protein to Alleviate PARP1-Mediated Cell Death Following Cerebral Ischemia by Jackson, Charles W., Xu, Jing, Escobar, Iris, Saul, Isabel, Fagerli, Eric, Dave, Kunjan R., Perez-Pinzon, Miguel A.

“…Stroke remains a leading cause of mortality; however, available therapeutics are limited. The study of ischemic tolerance, in paradigms such as resveratrol…”
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Resveratrol Preconditioning Mitigates Ischemia-Induced Septal Cholinergic Cell Loss and Memory Impairments by López-Morales, Mikahela A., Escobar, Iris, Saul, Isabel, Jackson, Charles W., Ferrier, Fernando J., Fagerli, Eric A., Raval, Ami P., Dave, Kunjan R., Perez-Pinzon, Miguel A.

“…Cholinergic cells originating from the nuclei of the basal forebrain (BF) are critical for supporting various memory processes, yet BF cholinergic cell…”
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Post cardiac arrest physical exercise mitigates cell death in the septal and thalamic nuclei and ameliorates contextual fear conditioning deficits in rats by Ferrier, Fernando J, Saul, Isabel, Khoury, Nathalie, Ruiz, Alexander J, Lao, Efrain J Perez, Escobar, Iris, Dave, Kunjan R, Young, Juan I, Perez-Pinzon, Miguel A

“…A major concern for cardiac arrest (CA) survivors is the manifestation of long-term cognitive impairments. Physical exercise (PE) is a well-established…”
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Resveratrol Preconditioning Induces a Novel Extended Window of Ischemic Tolerance in the Mouse Brain by Koronowski, Kevin B, Dave, Kunjan R, Saul, Isabel, Camarena, Vladimir, Thompson, John W, Neumann, Jake T, Young, Juan I, Perez-Pinzon, Miguel A

“…BACKGROUND AND PURPOSE—Prophylactic treatments that afford neuroprotection against stroke may emerge from the field of preconditioning. Resveratrol mimics…”
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