Search Results - "Sauerwein, W."

Hitting hotspots: spatial targeting of malaria for control and elimination by Bousema, Teun, Griffin, Jamie T, Sauerwein, Robert W, Smith, David L, Churcher, Thomas S, Takken, Willem, Ghani, Azra, Drakeley, Chris, Gosling, Roly

“…In more academic terms, an active focus of malaria transmission is a geographical area that supports malaria transmission, where the local Anopheles population…”
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Experimental human challenge infections can accelerate clinical malaria vaccine development by Sauerwein, Robert W, Roestenberg, Meta, Moorthy, Vasee S

“…These authors put forward their view that the information obtained from experimental human malaria infections justifies the minimal potential risks in…”
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Outcomes of controlled human malaria infection after BCG vaccination by Walk, Jona, de Bree, L. Charlotte J., Graumans, Wouter, Stoter, Rianne, van Gemert, Geert-Jan, van de Vegte-Bolmer, Marga, Teelen, Karina, Hermsen, Cornelus C., Arts, Rob J. W., Behet, Marije C., Keramati, Farid, Moorlag, Simone J. C. F. M., Yang, Annie S. P., van Crevel, Reinout, Aaby, Peter, de Mast, Quirijn, van der Ven, André J. A. M., Stabell Benn, Christine, Netea, Mihai G., Sauerwein, Robert W.

“…Recent evidence suggests that certain vaccines, including Bacillus-Calmette Guérin (BCG), can induce changes in the innate immune system with non-specific…”
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Fast and fierce versus slow and smooth: Heterogeneity in immune responses to Plasmodium in the controlled human malaria infection model by Yap, Xi Zen, McCall, Matthew B. B., Sauerwein, Robert W.

“…Controlled human malaria infection (CHMI) is an established model in clinical malaria research. Upon exposure to Plasmodium falciparum parasites, malaria‐naive…”
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How malaria modulates memory: activation and dysregulation of B cells in Plasmodium infection by Scholzen, Anja, Sauerwein, Robert W

“…Humoral immune responses play a major role in naturally acquired immunity to malaria, but are slow to develop and ineffectively maintained. Although this may…”
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Activatory Receptor NKp30 Predicts NK Cell Activation During Controlled Human Malaria Infection by Walk, Jona, Sauerwein, Robert W

“…Natural killer (NK) cells are known to be activated during malaria infection, exhibiting both cytokine production and cytotoxic functions. However, NK cells…”
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Radiotherapy for ocular tumours by Stannard, C, Sauerwein, W, Maree, G, Lecuona, K

“…Ocular tumours present a therapeutic challenge because of the sensitive tissues involved and the necessity to destroy the tumour while minimising visual loss…”
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Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study by Roestenberg, Meta, MD, Teirlinck, Anne C, MSc, McCall, Matthew BB, MD, Teelen, Karina, BSc, Makamdop, Krystelle Nganou, MSc, Wiersma, Jorien, ADN, Arens, Theo, BSc, Beckers, Pieter, PhD, van Gemert, GeertJan, BSc, van de Vegte-Bolmer, Marga, BSc, van der Ven, André JAM, Prof, Luty, Adrian JF, PhD, Hermsen, Cornelus C, PhD, Sauerwein, Robert W, Prof

“…Summary Background We have shown that immunity to infection with Plasmodium falciparum can be induced experimentally in malaria-naive volunteers through…”
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Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans by Teirlinck, Anne C, McCall, Matthew B B, Roestenberg, Meta, Scholzen, Anja, Woestenenk, Rob, de Mast, Quirijn, van der Ven, Andre J A M, Hermsen, Cornelus C, Luty, Adrian J F, Sauerwein, Robert W

“…Cellular responses to Plasmodium falciparum parasites, in particular interferon-gamma (IFNγ) production, play an important role in anti-malarial immunity…”
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Biomarkers of cellular aging during a controlled human malaria infection by Miglar, Aurelie, Reuling, Isaie J., Yap, Xi Zen, Färnert, Anna, Sauerwein, Robert W., Asghar, Muhammad

“…Cellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high…”
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Efficacy and Safety of the Mosquitocidal Drug Ivermectin to Prevent Malaria Transmission After Treatment: A Double-Blind, Randomized, Clinical Trial by Lin Ouédraogo, André, Bastiaens, Guido J. H., Tiono, Alfred B., Guelbéogo, Wamdaogo M., Kobylinski, Kevin C., Ouédraogo, Alphonse, Barry, Aïssata, Bougouma, Edith C., Nebie, Issa, San Ouattara, Maurice, Lanke, Kjerstin H. W., Fleckenstein, Lawrence, Sauerwein, Robert W., Slater, Hannah C., Churcher, Thomas S., Sirima, Sodiomon B., Drakeley, Chris, Bousema, Teun

“…Background. Artemisinin combination therapy effectively clears asexual malaria parasites and immature gametocytes but does not prevent posttreatment malaria…”
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The Impact of Hotspot-Targeted Interventions on Malaria Transmission in Rachuonyo South District in the Western Kenyan Highlands: A Cluster-Randomized Controlled Trial by Bousema, Teun, Stresman, Gillian, Baidjoe, Amrish Y, Bradley, John, Knight, Philip, Stone, William, Osoti, Victor, Makori, Euniah, Owaga, Chrispin, Odongo, Wycliffe, China, Pauline, Shagari, Shehu, Doumbo, Ogobara K, Sauerwein, Robert W, Kariuki, Simon, Drakeley, Chris, Stevenson, Jennifer, Cox, Jonathan

“…Malaria transmission is highly heterogeneous, generating malaria hotspots that can fuel malaria transmission across a wider area. Targeting hotspots may…”
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Assessing the impact of next-generation rapid diagnostic tests on Plasmodium falciparum malaria elimination strategies by Slater, Hannah C., Ross, Amanda, Ouédraogo, André Lin, White, Lisa J., Nguon, Chea, Walker, Patrick G.T., Ngor, Pengby, Aguas, Ricardo, Silal, Sheetal P., Dondorp, Arjen M., La Barre, Paul, Burton, Robert, Sauerwein, Robert W., Drakeley, Chris, Smith, Thomas A., Bousema, Teun, Ghani, Azra C.

“…Mass-screen-and-treat and targeted mass-drug-administration strategies are being considered as a means to interrupt transmission of Plasmodium falciparum…”
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CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research by Boltryk, Sylwia D., Passecker, Armin, Alder, Arne, Carrington, Eilidh, van de Vegte-Bolmer, Marga, van Gemert, Geert-Jan, van der Starre, Alex, Beck, Hans-Peter, Sauerwein, Robert W., Kooij, Taco W. A., Brancucci, Nicolas M. B., Proellochs, Nicholas I., Gilberger, Tim-Wolf, Voss, Till S.

“…The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of infected humans. During each replication cycle, a small proportion of…”
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Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children by Kurtovic, Liriye, Behet, Marije C, Feng, Gaoqian, Reiling, Linda, Chelimo, Kiprotich, Dent, Arlene E, Mueller, Ivo, Kazura, James W, Sauerwein, Robert W, Fowkes, Freya J I, Beeson, James G

“…Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody mechanisms that neutralize sporozoites…”
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Interferon-γ—central mediator of protective immune responses against the pre-erythrocytic and blood stage of malaria by McCall, Matthew B. B., Sauerwein, Robert W.

“…Review underscores the ubiquitous contribution of IFN‐δ to immune responses against malaria, evidence for its protective role and critical issues relating to…”
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Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45 by Kundu, Prasun, Semesi, Anthony, Jore, Matthijs M., Morin, Merribeth J., Price, Virginia L., Liang, Alice, Li, Jingxing, Miura, Kazutoyo, Sauerwein, Robert W., King, C. Richter, Julien, Jean-Philippe

“…Interventions that can block the transmission of malaria-causing Plasmodium falciparum (Pf) between the human host and Anopheles vector have the potential to…”
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Transmission blocking malaria vaccines: Assays and candidates in clinical development by Sauerwein, R.W, Bousema, T

“…Abstract Stimulated by recent advances in malaria control and increased funding, the elimination of malaria is now considered to be an attainable goal for an…”
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Three members of the 6-cys protein family of Plasmodium play a role in gamete fertility by van Dijk, Melissa R, van Schaijk, Ben C L, Khan, Shahid M, van Dooren, Maaike W, Ramesar, Jai, Kaczanowski, Szymon, van Gemert, Geert-Jan, Kroeze, Hans, Stunnenberg, Hendrik G, Eling, Wijnand M, Sauerwein, Robert W, Waters, Andrew P, Janse, Chris J

“…The process of fertilization is critically dependent on the mutual recognition of gametes and in Plasmodium, the male gamete surface protein P48/45 is vital to…”
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Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density by Bradley, John, Stone, Will, Da, Dari F, Morlais, Isabelle, Dicko, Alassane, Cohuet, Anna, Guelbeogo, Wamdaogo M, Mahamar, Almahamoudou, Nsango, Sandrine, Soumaré, Harouna M, Diawara, Halimatou, Lanke, Kjerstin, Graumans, Wouter, Siebelink-Stoter, Rianne, van de Vegte-Bolmer, Marga, Chen, Ingrid, Tiono, Alfred, Gonçalves, Bronner Pamplona, Gosling, Roland, Sauerwein, Robert W, Drakeley, Chris, Churcher, Thomas S, Bousema, Teun

“…Understanding the importance of gametocyte density on human-to-mosquito transmission is of immediate relevance to malaria control. Previous work (Churcher et…”
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