Search Results - "Sauerwein, R W"

Transmission blocking malaria vaccines: Assays and candidates in clinical development by Sauerwein, R.W, Bousema, T

“…Abstract Stimulated by recent advances in malaria control and increased funding, the elimination of malaria is now considered to be an attainable goal for an…”
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The Spiroindolone Drug Candidate NITD609 Potently Inhibits Gametocytogenesis and Blocks Plasmodium falciparum Transmission to Anopheles Mosquito Vector by PELT-KOOPS, J. C. Van, PETT, H. E, GRAUMANS, W, DER VEGTE-BOLMER, M. Van, GEMERT, G. J. Van, ROTTMANN, M, YEUNG, B. K. S, DIAGANA, T. T, SAUERWEIN, R. W

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A Pfs48/45-based vaccine to block Plasmodium falciparum transmission: phase 1, open-label, clinical trial by Alkema, M, Smit, M J, Marin-Mogollon, C, Totté, K, Teelen, K, van Gemert, G J, van de Vegte-Bolmer, M, Mordmüller, B G, Reimer, J M, Lövgren-Bengtsson, K L, Sauerwein, R W, Bousema, T, Plieskatt, J, Theisen, M, Jore, M M, McCall, M B B

“…The stalling global progress in malaria control highlights the need for novel tools for malaria elimination, including transmission-blocking vaccines…”
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Malaria vaccines getting close to clinical reality by Sauerwein, R.W, Richie, T.L

“…[...]major progress is being made by whole parasite vaccine approaches including manufacturing techniques, regimens and routes of administration [8-10]…”
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Inhibition of Plasmodium falciparum Oocyst Production by Membrane-Permeant Cysteine Protease Inhibitor E64d by EKSI, S, CZESNY, B, VAN GEMERT, G.-J, SAUERWEIN, R. W, ELING, W, WILLIAMSON, K. C

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longitudinal study of immune responses to Plasmodium falciparum sexual stage antigens in Tanzanian adults by BOUSEMA, J.T, DRAKELEY, C.J, KIHONDA, J, HENDRIKS, J.C.M, AKIM, N.I.J, ROEFFEN, W, SAUERWEIN, R.W

“…Next to children, adults form a substantial part of the infectious reservoir that is responsible for the spread of malaria. In this longitudinal study, we…”
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Transmission-reducing immunity is inversely related to age in Plasmodium falciparum gametocyte carriers by Drakeley, C.J, Bousema, J.T, Akim, N.I.J, Teelen, K, Roeffen, W, Lensen, A.H, Bolmer, M, Eling, W, Sauerwein, R.W

“…Immunity to the sexual stages of Plasmodium falciparum is induced during natural infections and can significantly reduce the transmission of parasites to…”
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Circulating concentrations of soluble granzyme A and B increase during natural and experimental Plasmodium falciparum infections by HERMSEN, C. C., KONIJNENBERG, Y., MULDER, L., LOÉ, C., VAN DEUREN, M., VAN DER MEER, J. W. M., VAN MIERLO, G. J., ELING, W. M. C., HACK, C. E., SAUERWEIN, R. W.

“…SUMMARY Release of soluble Granzymes (sGranzymes) is considered to reflect activation of cytotoxic T lymphocytes and NK cells. sGranzymes and a number of…”
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Correlation between Proinflammatory Cytokines and Antiinflammatory Mediators and the Severity of Disease in Meningococcal Infections by van Deuren, Marcel, van der Ven-Jongekrijg, Johanna, Bartelink, Anton K. M., van Dalen, Roelof, Sauerwein, Robert W., van der Meer, Jos W. M.

“…Pro- and antiinflammatory cytokines and mediators were measured in 39 patients with acute life-threatening meningococcal infections classified into 3 groups:…”
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Clinical outcome of experimental human malaria induced by Plasmodium falciparum-infected mosquitoes by VERHAGE, D. F, TELGT, D. S. C, BOUSEMA, J. T, HERMSEN, C. C, VAN GEMEN, Gj. A, VAN DER MEER, J. W. M, SAUERWEIN, R. W

“…Human experimental malaria infections have been safely carried out previously. The objective of this study was to evaluate infection rates and clinical safety…”
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Report of a Consultation on the Optimization of Clinical Challenge Trials for Evaluation of Candidate Blood Stage Malaria Vaccines, 18–19 March 2009, Bethesda, MD, USA by Moorthy, V.S, Diggs, C, Ferro, S, Good, M.F, Herrera, S, Hill, A.V, Imoukhuede, E.B, Kumar, S, Loucq, C, Marsh, K, Ockenhouse, C.F, Richie, T.L, Sauerwein, R.W

“…Abstract Development and optimization of first generation malaria vaccine candidates has been facilitated by the existence of a well-established Plasmodium…”
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Efficacy and Safety of the Mosquitocidal Drug Ivermectin to Prevent Malaria Transmission After Treatment: A Double-Blind, Randomized, Clinical Trial by Lin Ouédraogo, André, Bastiaens, Guido J. H., Tiono, Alfred B., Guelbéogo, Wamdaogo M., Kobylinski, Kevin C., Ouédraogo, Alphonse, Barry, Aïssata, Bougouma, Edith C., Nebie, Issa, San Ouattara, Maurice, Lanke, Kjerstin H. W., Fleckenstein, Lawrence, Sauerwein, Robert W., Slater, Hannah C., Churcher, Thomas S., Sirima, Sodiomon B., Drakeley, Chris, Bousema, Teun

“…Background. Artemisinin combination therapy effectively clears asexual malaria parasites and immature gametocytes but does not prevent posttreatment malaria…”
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Estimates of the infectious reservoir of Plasmodium falciparum malaria in The Gambia and in Tanzania by Drakeley, C.J., Akim, N.I.J., Sauerwein, R.W., Greenwood, B.M., Targett, G.A.T.

“…Separate studies carried out in Farafenni, The Gambia and Ifakara, Tanzania in 1990–1994 provided comparative data on population age structure, population…”
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A combination of new screening assays for prioritization of transmission-blocking antimalarials reveals distinct dynamics of marketed and experimental drugs by Bolscher, J M, Koolen, K M J, van Gemert, G J, van de Vegte-Bolmer, M G, Bousema, T, Leroy, D, Sauerwein, R W, Dechering, K J

“…The development of drugs to reduce malaria transmission is an important part of malaria eradication plans. We set out to develop and validate a combination of…”
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Sexual-stage antibody responses to P. falciparum in endemic populations by Bousema, J T, Drakeley, C J, Sauerwein, R W

“…Gametocytes and sporogonic stages are responsible for the spread of disease and drug resistance in the population. Sexual stage immunity affects the…”
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Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma : relation with subsequent adult respiratory distress syndrome and multiple organ failure by ROUMEN, R. M. H, HENDRIKS, VAN DER VEN-JONGEKRIJG, J, NIEUWENHUIJZEN, G. A. P, SAUERWEIN, R. W, VAN DER MEER, J. W. M, GORIS, R. J. A

“…This study investigates the course of serum cytokine levels in patients with multiple trauma, patients with a ruptured abdominal aortic aneurysm (AAA), and…”
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Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model by de Jong, G.M., Yap, X.Z., Walk, J., Dik, W.A., McCall, M.B.B., van Genderen, P.J.J., van Hellemond, J.J., Verbon, A., Sauerwein, R.W.

“…•Healthy malaria naïve volunteers participating in controlled human malaria infection (CHMI) show a pro-inflammatory response (in particular IFN-γ) or…”
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Treatment failure of pyrimethamine‐sulphadoxine and induction of Plasmodium falciparum gametocytaemia in children in western Kenya by Bousema, J. T., Gouagna, L. C., Meutstege, A. M., Okech, B. E., Akim, N. I. J., Githure, J. I., Beier, J. C., Sauerwein, R. W.

“…Summary Sub‐Saharan Africa faces increasing levels of resistance of Plasmodium falciparum parasites to the first‐line drug pyrimethamine‐sulphadoxine (SP)…”
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Differential induction of pro- and anti-inflammatory cytokines in whole blood by bacteria: effects of antibiotic treatment by FRIELING, J. T. M, MULDER, J. A, HENDRIKS, T, CURFS, J. H. A. J, VAN DER LINDEN, C. J, SAUERWEIN, R. W

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Ex vivo lymphocyte phenotyping during Plasmodium falciparum sporozoite immunization in humans by Bijker, E. M., Schats, R., Visser, L. G., Sauerwein, R. W., Scholzen, A.

“…Summary Immunization of malaria‐naïve volunteers under chemoprophylaxis with Plasmodium falciparum sporozoites (CPS) efficiently and reproducibly induces…”
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