Search Results - "Sauerheber, R. D."

Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide by Hyslop, P A, Hinshaw, D B, Halsey, W A, Schraufstätter, I U, Sauerheber, R D, Spragg, R G, Jackson, J H, Cochrane, C G

“…Inhibition of ADP phosphorylation by both glycolysis and mitochondria in P388D1 cells exposed to H2O2 is described. Net glucose uptake and lactate production…”
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Organization and interaction of cholesterol and phosphatidylcholine in model bilayer membranes by Hyslop, Paul A, Morel, Benoit, Sauerheber, Richard D

“…The molecular organization of sterols in liposomes of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) at 37 degrees C is examined by utilizing the…”
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The increase in bilayer fluidity of rat liver plasma membranes achieved by the local anesthetic benzyl alcohol affects the activity of intrinsic membrane enzymes by Gordon, L M, Sauerheber, R D, Esgate, J A, Dipple, I, Marchmont, R J, Houslay, M D

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Membrane structural/functional perturbations induced by gossypol. Effects on membrane order, liposome permeability, and insulin-sensitive hexose transport by de Peyster, A, Hyslop, P A, Kuhn, C E, Sauerheber, R D

“…The effects of gossypol on membrane structure and membrane-associated functions were studied to explore possible reasons for the ability of gossypol to disrupt…”
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Membrane structural/functional properties of adipocytes from normal and streptozotocin-diabetic rats by SAUERHEBER, R. D, KUHN, C. E, HYSLOP, P. A

“…The uptake of 2-deoxy-D-[1-14C]-glucose, in the presence and absence of insulin, was measured in adipocytes from normal and streptozotocin-diabetic animals,…”
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Insulin stimulation of glucose transport in isolated rat adipocytes. Functional evidence for insulin activation of intrinsic transporter activity within the plasma membrane by Hyslop, P A, Kuhn, C E, Sauerheber, R D

“…We examined the effects of the membrane-impermeant amino-group-modifying agent fluorescein isothiocyanate (FITC) on the basal and insulin-stimulated…”
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Temperature and benzyl alcohol as probes of the antilipolytic mechanism of insulin action in adipocytes by Hyslop, P A, Kuhn, C E, Sauerheber, R D

“…The temperature dependence of cAMP accumulation and glycerol release in response to epinephrine and insulin in adipocytes is examined. (1) Glycerol release in…”
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Membrane structural/functional properties of adipocytes from normal and streptozotocin-diabetic rats by Sauerheber, R. D., Kuhn, C. E., Hyslop, P. A.

“…Membrane structural/functional properties of adipocytes from normal and streptozotocin-diabetic rats. R D Sauerheber , C E Kuhn and P A Hyslop Abstract The…”
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Insulin stimulation of adipocyte membrane glucose transport. A graded biologic response insensitive to bilayer lipid disordering by Hyslop, P A, Kuhn, C E, Sauerheber, R D

“…Aspects of the mechanism by which insulin stimulates the membrane glucose transport system were examined by assessing the influence of the bilayer lipid…”
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Sensitivity of adipocyte basal and insulin-stimulated hexose transport to the membrane lipid structure by Hutchinson, B T, Hyslop, P A, Kuhn, C E, Sauerheber, R D

“…A series of anesthetic alcohols inhibited basal and insulin-stimulated 2-deoxy-D-[1-14C]glucose transport in adipocytes over total alcohol concentration ranges…”
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Glucagon-stimulated adenylate cyclase detects a selective perturbation of the inner half of the liver plasma-membrane bilayer achieved by the local anaesthetic prilocaine by Houslay, M D, Dipple, I, Rawal, S, Sauerheber, R D, Esgate, J A, Gordon, L M

“…Prilocaine can increase the fluidity of rat liver plasma membranes, as indicated by a fatty acid spin-probe. This led to the activation of the membrane-bound…”
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Temperature optimum of insulin-stimulated 2-deoxy-D-glucose uptake in rat adipocytes. Correlation of cellular transport with membrane spin-label and fluorescence-label data by Hyslop, P A, Kuhn, C E, Sauerheber, R D

“…The effects of temperature alterations between 22 degrees C and 48 degrees C on basal and insulin-stimulated 2-deoxy-D-[1-14C]glucose uptake were examined in…”
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Spin label studies on rat liver plasma membrane: calcium effects on membrane fluidity by Sauerheber, R D, Gordon, L M

“…Spin-labeled stearic acid probes were incorporated into rat liver plasma membrane purified by a zonal centrifugation procedure. Temperature effects on the…”
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Alcohols inhibit adipocyte basal and insulin-stimulated glucose uptake and increase the membrane lipid fluidity by Sauerheber, R D, Esgate, J A, Kuhn, C E

“…Benzyl alcohol and ethanol, at aqueous concentrations that cause local anesthesia of rat sciatic nerve, affect structural and functional properties of rat…”
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Effects of insulin on the lipid structure of liver plasma membrane measured with fluorescence and ESR spectroscopic methods by Hyslop, P A, York, D A, Sauerheber, R D

“…Insulin increased the lipid order of rat and mouse liver plasma membrane domains sampled by the hydrophobic fluorescent probe 1,6-diphenyl-1,3,5-hexatriene in…”
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Effect of calcium, insulin and growth hormone on membrane fluidity. A spin label study of rat adipocyte and human erythrocyte ghosts by Sauerheber, R D, Lewis, U J, Esgate, J A, Gordon, L M

“…ESR spectra were recorded from rat epididymal adipocyte ghosts labeled with the 5-nitroxide stearic acid spin probe, I(12,3). Polarity-corrected and…”
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Studies on spin-labelled egg lecithin dispersions by Gordon, L M, Sauerheber, R D

“…ESR spectra of egg lecithin dispersions labelled with 5-nitroxide stearic acid are recorded with a 50 G field sweep, and also with a new technique which…”
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Spin-label studies on rat liver and heart plasma membranes: do probe-probe interactions interfere with the measurement of membrane properties? by Sauerheber, R D, Gordon, L M, Crosland, R D, Kuwahara, M D

“…The structures of purified rat liver and heart plasma membranes were studied with the 5-nitroxide stearic acid spin probe, I(12,3). ESR spectra were recorded…”
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Effects of calcium, lanthanum, and temperature on the fluidity of spin-labeled human platelets by Sauerheber, R D, Zimmermann, T S, Esgate, J A, VanderLaan, W P, Gordon, L M

“…Previous platelet studies have shown that calcium plays important roles in stimulus-secretion coupling, aggregation, and other membrane-associated functions…”
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The selective effects of charged local anaesthetics on the glucagon- and fluoride-stimulated adenylate cyclase activity of rat-liver plasma membranes by Gordon, L M, Dipple, I, Sauerheber, R D, Esgate, J A, Houslay, M D

“…The cationic local anaesthetics carbocaine and nupercaine were found to increase the fluoride-stimulated adenylate cyclase up to a maximum level; above this…”
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