Population genetic data and forensic parameters of 30 autosomal InDel markers in Santa Catarina State population, Southern Brazil

Population genetic data and forensic parameters of 30 autosomal InDel markers in Santa Catarina State population, Southern Brazil

The application of DNA technology in forensic investigations has grown rapidly in the last 25 years and with an exponential increase of short tandem repeats (STRs) data, usually presented as allele frequencies, that may be later used as databases for forensic and population genetics purposes. Thereb...

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Bibliographic Details
Published in:Molecular biology reports Vol. 41; no. 8; pp. 5429 - 5433
Main Authors: Torres, Sandra Regina Rachadel, Uehara, Clineu Julien Seki, Sutter-Latorre, Ana Frederica, de Almeida, Bibiana Sgorla, Sauerbier, Tania Streck, Muniz, Yara Costa Netto, Marrero, Andrea Rita, de Souza, Ilíada Rainha
Format: Journal Article
Language:English
Published: Dordrecht Springer-Verlag 01-08-2014
Springer Netherlands
Springer Nature B.V
Subjects:
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Brazil
Databases, Genetic
DNA
Ethnic Groups - genetics
Forensic sciences
Gene Frequency
genetic distance
Genetic Loci
Genetic Markers
Genetics, Population
Genome, Human
Genotyping Techniques
heterozygosity
Heterozygote
Histology
Humans
INDEL Mutation
Life Sciences
Linkage Disequilibrium
loci
Microsatellite Repeats
Molecular biology
Morphology
paternity
Phylogeography
Polymorphism
Polymorphism, Genetic
Population genetics
probability
Sequence Analysis, DNA
single nucleotide polymorphism
Brazil
United States
Korean Peninsula
Brazilian population
InDel markers
Polymorphisms
Investigator DIPplex
Forensic parameters
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Summary:The application of DNA technology in forensic investigations has grown rapidly in the last 25 years and with an exponential increase of short tandem repeats (STRs) data, usually presented as allele frequencies, that may be later used as databases for forensic and population genetics purposes. Thereby, classes of molecular markers such as single nucleotide polymorphisms and insertions/deletions (InDels) have been presented as another option of genetic marker sets. These markers can be used in paternity cases, when mutations in STR polymorphisms are present, as well as in highly degraded DNA analysis. In the present study, the allele frequencies and heterozygosity (H) of a 30 InDel markers set were determined and the forensic efficacy was evaluated through estimation of discrimination power (DP), match probability, typical paternity index and power of paternity exclusion in 108 unrelated volunteers from the State of Santa Catarina (South Brazil). The observed H per locus showed a range between 0.370 and 0.574 (mean = 0.479). HLD128 was the locus with the highest DP (DP = 0.656). DP for all markers combined was greater than 99.9999999999646 % which provides satisfactory levels of information for forensic demands. Genetic comparisons (exact tests of population differentiation and pairwise genetic distances) revealed that the population of Santa Catarina State differs from Korea and USA Afro-American populations but is similar to the Portuguese, German, Polish, Spanish and Basque populations.
Bibliography:http://dx.doi.org/10.1007/s11033-014-3414-0
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-014-3414-0