Search Results - "Sauer, Karsten"

An Effective COVID-19 Vaccine Needs to Engage T Cells by Sauer, Karsten, Harris, Tim

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IL-21 Is Required to Control Chronic Viral Infection by Elsaesser, Heidi, Sauer, Karsten, Brooks, David G

“…CD4⁺ and CD8⁺ T cell functions are rapidly aborted during chronic infection, preventing viral clearance. CD4⁺ T cell help is required throughout chronic…”
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Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides by Elich, Mila, Sauer, Karsten

“…One of the most paramount receptor-induced signal transduction mechanisms in hematopoietic cells is production of the lipid second messenger…”
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hCD2-iCre and Vav-iCre mediated gene recombination patterns in murine hematopoietic cells by Siegemund, Sabine, Shepherd, Jovan, Xiao, Changchun, Sauer, Karsten

“…Cre-recombinase mediated conditional deletion of Lox-P site flanked ("floxed") genes is widely used for functional gene annotation in mice. Many different…”
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Intratumoral injection and retention hold promise to improve cytokine therapies for cancer by Sauer, Karsten, Rakhra, Kavya, Wu, Kaida, Mehta, Naveen K, Michaelson, Jennifer S, Baeuerle, Patrick A

“…As powerful activators of the immune system, cytokines have been extensively explored for treating various cancers. But despite encouraging advances and some…”
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Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent by Westernberg, Luise, Conche, Claire, Huang, Yina Hsing, Rigaud, Stephanie, Deng, Yisong, Siegemund, Sabine, Mukherjee, Sayak, Nosaka, Lyn'Al, Das, Jayajit, Sauer, Karsten

“…β-selection is the most pivotal event determining αβ T cell fate. Here, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic…”
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Agonist antibody that induces human malignant cells to kill one another by Yea, Kyungmoo, Zhang, Hongkai, Xie, Jia, Jones, Teresa M., Lin, Chih-Wei, Francesconi, Walter, Berton, Fulvia, Fallahi, Mohammad, Sauer, Karsten, Lerner, Richard A.

“…An attractive, but as yet generally unrealized, approach to cancer therapy concerns discovering agents that change the state of differentiation of the cancer…”
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Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration by Xu, Xiaolu, Jaeger, Emily R, Wang, Xinxin, Lagler-Ferrez, Erica, Batalov, Serge, Mathis, Nancy L, Wiltshire, Tim, Walker, John R, Cooke, Michael P, Sauer, Karsten, Huang, Yina H

“…Chemokines promote T cell migration by transmitting signals that induce T cell polarization and integrin activation and adhesion. Mst1 kinase is a key signal…”
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Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire by Rybakin, Vasily, Westernberg, Luise, Fu, Guo, Kim, Hee-Ok, Ampudia, Jeanette, Sauer, Karsten, Gascoigne, Nicholas R J

“…Development of thymocytes through the positive selection checkpoint requires the rearrangement and expression of a suitable T cell receptor (TCR) α-chain that…”
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Profiling of Tyrosine Phosphorylation Pathways in Human Cells Using Mass Spectrometry by Salomon, Arthur R., Ficarro, Scott B., Brill, Laurence M., Brinker, Achim, Phung, Qui T., Ericson, Christer, Sauer, Karsten, Brock, Ansgar, Horn, David M., Schultz, Peter G., Peters, Eric C.

“…The reversible phosphorylation of tyrosine residues is an important mechanism for modulating biological processes such as cellular signaling, differentiation,…”
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In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness by Mukherjee, Sayak, Rigaud, Stephanie, Seok, Sang-Cheol, Fu, Guo, Prochenka, Agnieszka, Dworkin, Michael, Gascoigne, Nicholas R J, Vieland, Veronica J, Sauer, Karsten, Das, Jayajit

“…The inositol-phosphate messenger inositol(1,3,4,5)tetrakisphosphate (IP4) is essential for thymocyte positive selection by regulating plasma-membrane…”
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Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation by Miller, Andrew T, Sandberg, Mark, Huang, Yina H, Young, Michael, Sutton, Susan, Sauer, Karsten, Cooke, Michael P

“…Antigen receptor-mediated production of inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) in lymphocytes triggers the release of Ca2+ from intracellular stores; this…”
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801 PRIME™ IL-15 (RPTR-147): Preliminary clinical results and biomarker analysis from a first-in-human Phase 1 study of IL-15 loaded peripherally-derived autologous T cell therapy in solid tumor patients by Hamilton, Erika, Nikiforow, Sarah, Bardwell, Philip, McInnis, Christine, Zhang, Jeffrey, Blumenschein, George, Cristea, Mihaela, Osman, Keren, Shields, Anthony, Motta, Marlyane, Bilic, Sanela, Schoenborn-Kellenberger, Oliver, Rakestraw, James, Carey, Shawn, Geretti, Elena, Sauer, Karsten, Harris, Tim, Maniar, Tap, Hewes, Becker, Andresen, Thomas, Fitzgerald, Jonathan, Kluger, Harriet

“…BackgroundRPTR-147 is a novel autologous non-genetically modified multi-clonal T cell product loaded with an IL15-Fc nanogel. The product was derived from rare…”
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A Minor Catalytic Activity of Src Family Kinases Is Sufficient for Maximal Activation of Mast Cells via the High-Affinity IgE Receptor by Poderycki, Michael, Tomimori, Yoshiaki, Ando, Tomoaki, Xiao, Wenbin, Maeda-Yamamoto, Mari, Sauer, Karsten, Kawakami, Yuko, Kawakami, Toshiaki

“…Src family kinases (SFK) are critical for initiating and regulating the response of mast cells activated by engagement of the high-affinity IgE receptor,…”
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A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions by Hirve, Nupura, Levytskyy, Roman M, Rigaud, Stephanie, Guimond, David M, Zal, Tomasz, Sauer, Karsten, Tsoukas, Constantine D

“…Binding of the membrane phospholipid phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) to the Pleckstrin Homology (PH) domain of the Tec family protein…”
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A Conserved Salt Bridge in the G Loop of Multiple Protein Kinases Is Important for Catalysis and for In Vivo Lyn Function by Barouch-Bentov, Rina, Che, Jianwei, Lee, Christian C., Yang, Yating, Herman, Ann, Jia, Yong, Velentza, Anastasia, Watson, James, Sternberg, Luise, Kim, Sunjun, Ziaee, Niusha, Miller, Andrew, Jackson, Carie, Fujimoto, Manabu, Young, Mike, Batalov, Serge, Liu, Yi, Warmuth, Markus, Wiltshire, Tim, Cooke, Michael P., Sauer, Karsten

“…The glycine-rich G loop controls ATP binding and phosphate transfer in protein kinases. Here we show that the functions of Src family and Abl protein tyrosine…”
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Hematopoietic Progenitor Kinase 1 Associates Physically and Functionally with the Adaptor Proteins B Cell Linker Protein and SLP-76 in Lymphocytes by Sauer, K, Liou, J, Singh, S B, Yablonski, D, Weiss, A, Perlmutter, R M

“…B cell linker protein (BLNK) is a SLP-76-related adaptor protein essential for signal transduction from the BCR. To identify components of BLNK-associated…”
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Inositol (1,4,5) Trisphosphate 3 Kinase B Controls Positive Selection of T Cells and Modulates Erk Activity by Wen, Ben G., Pletcher, Mathew T., Warashina, Masaki, Choe, Sun Hui, Ziaee, Niusha, Wiltshire, Tim, Sauer, Karsten, Cooke, Michael P., Schultz, Peter G.

“…The mechanisms governing positive selection of T cells in the thymus are still incompletely understood. Here, we describe a N-ethyl-N-nitrosourea induced…”
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Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis by Lenox, Laurie E., PhD, Kambayashi, Taku, MD, PhD, Okumura, Mariko, BS, Prieto, Christopher, BS, Sauer, Karsten, PhD, Bunte, Ralph M., DVM, Diplomate, ACVP, Jordan, Martha S., PhD, Koretzky, Gary A., MD, PhD, Nichols, Kim E., MD

“…Background Lymphocyte cytosolic protein 2, also known as Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76), is an essential…”
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Mechanisms of drug resistance in kinases by Barouch-Bentov, Rina, Sauer, Karsten

“…because of their important roles in disease and excellent 'druggability', kinases have become the second largest drug target family. The great success of the…”
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