Search Results - "Saubermann, L J"

Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease by Kugathasan, S, Saubermann, L J, Smith, L, Kou, D, Itoh, J, Binion, D G, Levine, A D, Blumberg, R S, Fiocchi, C

“…Background and aims:Crohn’s disease is a life-long form of inflammatory bowel disease (IBD) mediated by mucosal immune abnormalities. Understanding of the…”
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Activation of natural killer T cells by α-galactosylceramide in the presence of CD1d provides protection against colitis in mice by Saubermann, Lawrence J., Beck, Paul, De Jong, Ype P., Pitman, Richard S., Ryan, Mark S., Kim, Hyun S., Snapper, Scott, Hagen, Susan J., Kanauchi, Osamu, Motoki, Kazuhiro, Sakai, Teruyuki, Terhorst, Cox, Koezuka, Yasuhiko, Podolsky, Daniel K., Blumberg, Richard S., Exley, Mark, Balk, Steven P.

“…Background & Aims: CD1d is a major histocompatibility complex class I–like molecule that presents glycolipid antigens to a subset of natural killer (NK)1.1+ T…”
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Persistent clonal expansions of peripheral blood CD4+ lymphocytes in chronic inflammatory bowel disease by Probert, CS, Chott, A, Turner, JR, Saubermann, LJ, Stevens, AC, Bodinaku, K, Elson, CO, Balk, SP, Blumberg, RS

“…It is increasingly recognized that chronic Ag exposure may lead to clonal expansions of T cells, including those within the peripheral blood. Inflammatory…”
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Animal models of mucosal inflammation and their relation to human inflammatory bowel disease by Blumberg, Richard S, Saubermann, Lawrence J, Strober, Warren

“…Animal models of inflammatory bowel disease (IBD) have been useful in the identification of those immune responses uniquely involved in IBD pathogenesis and in…”
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Prevalence of an ulcerative colitis-associated CD8+ T cell receptor β-chain CDR3-region motif and its association with disease activity by PROBERT, C. S, CHOTT, A, SAUBERMANN, L. J, STEVENS, A. C, BALK, S. P, BLUMBERG, R. S

“…The normal human intestinal mucosa contains clonal T cell expansions. Clonal populations of T cells can be determined through evaluation of the idiotypic,…”
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Duodenal variceal bleeding treated with a combination of endoscopic ligation and sclerotherapy by Omata, F, Itoh, T, Shibayama, Y, Ide, H, Takahashi, H, Ueno, F, Saubermann, L J, Matsuzaki, S

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Endogenous PPARγ mediates anti-inflammatory activity in murine ischemia-reperfusion injury by Nakajima, Atsushi, Wada, Koichiro, Miki, Hiroshi, Kubota, Naoto, Nakajima, Noriko, Terauchi, Yasuo, Ohnishi, Shin, Saubermann, Lawrence J., Kadowaki, Takashi, Blumberg, Richard S., Nagai, Ryozo, Matsuhashi, Nobuyuki

“…Background & Aims: Peroxisome proliferator–activated receptor γ (PPARγ) is a nuclear receptor whose activation has been linked to several physiologic pathways…”
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Fractalkine Is an Epithelial and Endothelial Cell-Derived Chemoattractant for Intraepithelial Lymphocytes in the Small Intestinal Mucosa by Muehlhoefer, Andreas, Saubermann, Lawrence J, Gu, Xuibin, Luedtke-Heckenkamp, Kerstin, Xavier, Ramnik, Blumberg, Richard S, Podolsky, Daniel K, MacDermott, Richard P, Reinecker, Hans-Christian

“…Fractalkine is a unique chemokine that combines properties of both chemoattractants and adhesion molecules. Fractalkine mRNA expression has been observed in…”
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pANCA—is this your final answer? by Saubermann, Lawrence J.

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Mesalamine: safe at first look by Saubermann, L J, Wolf, J L

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Evidence of T cell receptor beta-chain patterns in inflammatory and noninflammatory bowel disease states by Saubermann, L J, Probert, C S, Christ, A D, Chott, A, Turner, J R, Stevens, A C, Balk, S P, Blumberg, R S

“…T cell activation, as defined by expression of relevant cell surface molecules, such as the interleukin-2 receptor (CD25), is increased in many chronic…”
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Antigen presentation by intestinal epithelial cells by Blumberg, Richard S, Lencer, Wayne I, Zhu, Xiaoping, Kim, Hyun-Sil, Claypool, Steven, Balk, Steven P, Saubermann, Lawrence J, Colgan, Sean P

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Analysis of human common bile duct-associated T cells: evidence for oligoclonality, T cell clonal persistence, and epithelial cell recognition by Probert, CS, Christ, AD, Saubermann, LJ, Turner, JR, Chott, A, Carr-Locke, D, Balk, SP, Blumberg, RS

“…The phenotype of T cells associated with the common bile duct (CBD) is unknown. We investigated the hypothesis that they behave like other intraepithelial…”
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Peroxisome proliferator-activated receptor γ inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells by SCHAEFER, Katherine L, WADA, Koichiro, TAKAHASHI, Hirokazu, MATSUHASHI, Nobuyuki, OHNISHI, Shin, WOLFE, M. Michael, TURNER, Jerrold R, NAKAJIMA, Atsushi, BORKAN, Steven C, SAUBERMANN, Lawrence J

“…Activation of the nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) inhibits growth and survival of hepatocellular…”
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Limited CD4 T-cell diversity associated with colitis in T-cell receptor α mutant mice requires a T helper 2 environment by Mizoguchi, Atsushi, Mizoguchi, Emiko, Saubermann, Lawrence J., Higaki, Koichi, Blumberg, Richard S., Bhan, Atul K.

“…Background & Aims: T-cell receptor α mutant (TCRα−/−) mice spontaneously develop chronic colitis mediated by CD4+ TCRα−β+ T cells. The aim of this study was to…”
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pANCA--is this your final answer? by Saubermann, L J

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Peroxisome proliferator‐activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis by Saubermann, Lawrence J., Nakajima, Atsushi, Wada, Koichiro, Zhao, Shuping, Terauchi, Yasuo, Kadowaki, Takashi, Aburatani, Hiroyuki, Matsuhashi, Nobuyuki, Nagai, Ryozo, Blumberg, Richard S.

“…Peroxisome proliferator‐activated receptor gamma (PPARγ), a member of a nuclear transcription factor family, has been previously demonstrated to have…”
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Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator‐activated receptor‐γ ligands on t helper type 1 chemokine regulation include nontranscriptional control mechanisms by Schaefer, Katherine L, Denevich, Svetlana, Ma, Chen, Cooley, Shane R, Nakajima, Atsushi, Wada, Koichiro, Schlezinger, Jennifer, Sherr, David, Saubermann, Lawrence J

“…Crohn's disease is associated with an excessive T helper (TH) type 1 inflammatory immune response. Reducing the influx of disease‐associated CD4+ TH1 cells…”
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Prevalence of an ulcerative colitis-associated CD8^sup +^ T cell receptor [beta]-Chain CDR3-region motif and its association with disease activity1 by Probert, C S, Chott, A, Saubermann, L J, Stevens, A C

“…The normal human intestinal mucosa contains clonal T cell expansions. Clonal populations of T cells can be determined through evaluation of the idiotypic,…”
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Prevalence of an Ulcerative Colitis-Associated CD8 super(+) T Cell Receptor beta -Chain CDR3-Region Motif and Its Association with Disease Activity by Probert, C S, Chott, A, Saubermann, L J, Stevens, A C, Balk, S P, Blumberg, R S

“…The normal human intestinal mucosa contains clonal T cell expansions. Clonal populations of T cells can be determined through evaluation of the idiotypic,…”
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