Search Results - "Satyshur, Kenneth A."

Molecular Mechanism and Evolution of Guanylate Kinase Regulation by (p)ppGpp by Liu, Kuanqing, Myers, Angela R., Pisithkul, Tippapha, Claas, Kathy R., Satyshur, Kenneth A., Amador-Noguez, Daniel, Keck, James L., Wang, Jue D.

“…The nucleotide (p)ppGpp mediates bacterial stress responses, but its targets and underlying mechanisms of action vary among bacterial species and remain…”
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Structure-specific DNA replication-fork recognition directs helicase and replication restart activities of the PriA helicase by Windgassen, Tricia A., Leroux, Maxime, Satyshur, Kenneth A., Sandler, Steven J., Keck, James L.

“…DNA replication restart, the essential process that reinitiates prematurely terminated genome replication reactions, relies on exquisitely specific recognition…”
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Structure-guided Engineering Enhances a Phytochrome-based Infrared Fluorescent Protein by Auldridge, Michele E., Satyshur, Kenneth A., Anstrom, David M., Forest, Katrina T.

“…Phytochrome is a multidomain dimeric red light photoreceptor that utilizes a chromophore-binding domain (CBD), a PHY domain, and an output module to induce…”
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Structural basis of PP2A activation by PTPA, an ATP- dependent activation chaperone by Guo, Feng, Stanevich, Vitali, Wlodarchak, Nathan, Sengupta, Rituparna, Jiang, Li, Satyshur, Kenneth A, Xing, Yongna

“…Proper activation of protein phosphatase 2A （PP2A） catalytic subunit is central for the complex PP2A regulation and is crucial for broad aspects of cellular…”
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Replication fork binding triggers structural changes in the PriA helicase that govern DNA replication restart in E. coli by Duckworth, Alexander T., Ducos, Peter L., McMillan, Sarah D., Satyshur, Kenneth A., Blumenthal, Katelien H., Deorio, Haley R., Larson, Joseph A., Sandler, Steven J., Grant, Timothy, Keck, James L.

“…Bacterial replisomes often dissociate from replication forks before chromosomal replication is complete. To avoid the lethal consequences of such situations,…”
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Sphingoid Bases Regulate the Sigma-1 Receptor-Sphingosine and N , N '-Dimethylsphingosine Are Endogenous Agonists by Li, Jing, Satyshur, Kenneth A, Guo, Lian-Wang, Ruoho, Arnold E

“…Both bioactive sphingolipids and Sigma-1 receptor (S1R) chaperones occur ubiquitously in mammalian cell membranes. Endogenous compounds that regulate the S1R…”
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Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants by Torres, Brian, Tyler, James S, Satyshur, Kenneth A, Ruoho, Arnold E

“…Phenylalanine and cysteine comprise common miss-sense variants (i.e., single nucleotide polymorphisms [SNPs]) at amino acid position 254 of the human…”
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X-ray crystal structure of the Escherichia coli RadD DNA repair protein bound to ADP reveals a novel zinc ribbon domain by Osorio Garcia, Miguel A, Satyshur, Kenneth A, Cox, Michael M, Keck, James L

“…Genome maintenance is an essential process in all cells. In prokaryotes, the RadD protein is important for survival under conditions that include DNA-damaging…”
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Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction by Anderson, Brent W, Liu, Kuanqing, Wolak, Christine, Dubiel, Katarzyna, She, Fukang, Satyshur, Kenneth A, Keck, James L, Wang, Jue D

“…The alarmone (p)ppGpp regulates diverse targets, yet its target specificity and evolution remain poorly understood. Here, we elucidate the mechanism by which…”
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Stereoelectronic and steric effects in side chains preorganize a protein main chain by Shoulders, Matthew D, Satyshur, Kenneth A, Forest, Katrina T, Raines, Ronald T

“…Preorganization is shown to endow a protein with extraordinary conformational stability. This preorganization is achieved by installing side-chain substituents…”
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Minor Alterations in Core Promoter Element Positioning Reveal Functional Plasticity of a Bacterial Transcription Factor by Chowdhury, Wamiah P, Satyshur, Kenneth A, Keck, James L, Kiley, Patricia J

“…IscR is a global transcription factor that regulates Fe-S cluster homeostasis and other functions in Escherichia coli by either activating or repressing…”
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Methylation-regulated decommissioning of multimeric PP2A complexes by Wu, Cheng-Guo, Zheng, Aiping, Jiang, Li, Rowse, Michael, Stanevich, Vitali, Chen, Hui, Li, Yitong, Satyshur, Kenneth A., Johnson, Benjamin, Gu, Ting-Jia, Liu, Zuojia, Xing, Yongna

“…Dynamic assembly/disassembly of signaling complexes are crucial for cellular functions. Specialized latency and activation chaperones control the biogenesis of…”
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The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1 by Stanevich, Vitali, Jiang, Li, Satyshur, Kenneth A., Li, Yongfeng, Jeffrey, Philip D., Li, Zhu, Menden, Patrick, Semmelhack, Martin F., Xing, Yongna

“…Proper formation of protein phosphatase 2A (PP2A) holoenzymes is essential for the fitness of all eukaryotic cells. Carboxyl methylation of the PP2A catalytic…”
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Structural basis of protein phosphatase 2A stable latency by Jiang, Li, Stanevich, Vitali, Satyshur, Kenneth A, Kong, Mei, Watkins, Guy R., Wadzinski, Brian E., Sengupta, Rituparna, Xing, Yongna

“…The catalytic subunit of protein phosphatase 2A (PP2Ac) is stabilized in a latent form by α4, a regulatory protein essential for cell survival and biogenesis…”
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Structural Insights into the Tumor-Promoting Function of the MTDH-SND1 Complex by Guo, Feng, Wan, Liling, Zheng, Aiping, Stanevich, Vitali, Wei, Yong, Satyshur, Kenneth A., Shen, Minhong, Lee, Woojong, Kang, Yibin, Xing, Yongna

“…Metadherin (MTDH) and Staphylococcal nuclease domain containing 1 (SND1) are overexpressed and interact in diverse cancer types. The structural mechanism of…”
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Identification of the Ah-receptor structural determinants for ligand preferences by Xing, Yongna, Nukaya, Manabu, Satyshur, Kenneth A, Jiang, Li, Stanevich, Vitali, Korkmaz, Elif Nihal, Burdette, Lisa, Kennedy, Gregory D, Cui, Qiang, Bradfield, Christopher A

“…The aryl hydrocarbon receptor (AHR) is a transcription factor that responds to diverse ligands and plays a critical role in toxicology, immune function, and…”
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Structure of the Ca2＋-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation by Wlodarchak, Nathan, Guo, Feng, Satyshur, Kenneth A, Jiang, Li, Jeffrey, Philip D, Sun, Tingwan, Stanevich, Vitali, Mumby, Marc C, Xing, Yongna

“…The B＂/PR72 family of protein phosphatase 2A （PP2A） is an important PP2A family involved in diverse cellular processes, and uniquely regulated by calcium…”
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The Recent Evolution of a Symbiotic Ion Channel in the Legume Family Altered Ion Conductance and Improved Functionality in Calcium Signaling by Venkateshwaran, Muthusubramanian, Cosme, Ana, Han, Lu, Banba, Mari, Satyshur, Kenneth A., Schleiff, Enrico, Parniske, Martin, Imaizumi-Anraku, Haruko, Ané, Jean-Michel

“…Arbuscular mycorrhiza and the rhizobia-legume symbiosis are two major root endosymbioses that facilitate plant nutrition. In Lotus japonicus, two symbiotic…”
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Extended Binding Site on Fibronectin for the Functional Upstream Domain of Protein F1 of Streptococcus pyogenes by Maurer, Lisa M., Tomasini-Johansson, Bianca R., Ma, Wenjiang, Annis, Douglas S., Eickstaedt, Nathan L., Ensenberger, Martin G., Satyshur, Kenneth A., Mosher, Deane F.

“…The 49-residue functional upstream domain (FUD) of Streptococcus pyogenes F1 adhesin interacts with fibronectin (FN) in a heretofore unknown manner that…”
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Structure and Cellular Roles of the RMI Core Complex from the Bloom Syndrome Dissolvasome by Hoadley, Kelly A., Xu, Dongyi, Xue, Yutong, Satyshur, Kenneth A., Wang, Weidong, Keck, James L.

“…BLM, the protein product of the gene mutated in Bloom syndrome, is one of five human RecQ helicases. It functions to separate double Holliday junction DNA…”
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