Search Results - "Satyamurthy, N"

PET of Brain Amyloid and Tau in Mild Cognitive Impairment by Small, Gary W, Kepe, Vladimir, Ercoli, Linda M, Siddarth, Prabha, Bookheimer, Susan Y, Miller, Karen J, Lavretsky, Helen, Burggren, Alison C, Cole, Greg M, Vinters, Harry V, Thompson, Paul M, Huang, S.-C, Satyamurthy, N, Phelps, Michael E, Barrio, Jorge R

“…A small molecule (FDDNP) that binds amyloid senile plaques and tau neurofibrillary tangles (the neuropathological findings in Alzheimer's disease) was injected…”
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In vitro detection of ( S)-naproxen and ibuprofen binding to plaques in the Alzheimer’s brain using the positron emission tomography molecular imaging probe 2-(1-{6-[(2-[ 18F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile by Agdeppa, E.D, Kepe, V, Petri, A, Satyamurthy, N, Liu, J, Huang, S.-C, Small, G.W, Cole, G.M, Barrio, J.R

“…Epidemiological studies have suggested that the chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) reduces the relative risk of Alzheimer’s disease…”
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Binding Characteristics of Radiofluorinated 6-Dialkylamino-2-Naphthylethylidene Derivatives as Positron Emission Tomography Imaging Probes for beta -Amyloid Plaques in Alzheimer's Disease by Agdeppa, Eric D, Kepe, Vladimir, Liu, Jie, Flores-Torres, Samuel, Satyamurthy, Nagichettiar, Petric, Andrej, Cole, Greg M, Small, Gary W, Huang, Sung-Cheng, Barrio, Jorge R

“…Senile plaques (SPs) and neurofibrillary tangles (NFTs) are hallmark pathologies accompanying the neurodegeneration involved in Alzheimer's disease (AD), for…”
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Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals by MACLAREN, D. C, GAMBHIR, S. S, HERSCHMAN, H. R, SATYAMURTHY, N, BARRIO, J. R, SHARFSTEIN, S, TOYOKUNI, T, WU, L, BERK, A. J, CHERRY, S. R, PHELPS, M. E

“…Reporter genes (e.g. beta-galactosidase, chloramphenicol-acetyltransferase, green fluorescent protein, luciferase) play critical roles in investigating…”
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Imaging Transgene Expression with Radionuclide Imaging Technologies by Gambhir, S.S., Herschman, H.R., Cherry, S.R., Barrio, J.R., Satyamurthy, N., Toyokuni, T., Phelps, M.E, Larson, S.M., Balatoni, J., Finn, R., Sadelain, M., Tjuvajev, J., Blasbergt, R.

“…A variety of imaging technologies are being investigated as tools for studying gene expression in living subjects. Noninvasive, repetitive and quantitative…”
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Noninvasive, quantitative imaging in living animals of a mutant dopamine D2 receptor reporter gene in which ligand binding is uncoupled from signal transduction by LIANG, Q, SATYAMURTHY, N, BARRIO, J. R, TOYOKUNI, T, PHELPS, M. P, GAMBHIR, S. S, HERSCHMAN, H. R

“…The dopamine D2 receptor (D2R) has been used in adenoviral delivery systems and in tumor cell xenografts as an in vivo reporter gene. D2R reporter gene…”
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Human Pharmacokinetic and Dosimetry Studies of [18F]FHBG: A Reporter Probe for Imaging Herpes Simplex Virus Type-1 Thymidine Kinase Reporter Gene Expression by Yaghoubi, Shahriar, Barrio, Jorge R, Dahlbom, Magnus, Iyer, Meera, Namavari, Mohammad, Satyamurthy, Nagichettiar, Goldman, Robin, Herschman, Harvey R, Phelps, Michael E, Gambhir, Sanjiv S

“…9-[4-[(18)F]fluoro-3-(hydroxymethyl)butyl]guanine ([(18)F]FHBG) has been used as a reporter probe to image expression of herpes simplex virus type-1 thymidine…”
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8-[18F]Fluoropenciclovir: An Improved Reporter Probe for Imaging HSV1-tk Reporter Gene Expression In Vivo Using PET by Iyer, Meera, Barrio, Jorge R, Namavari, Mohammad, Bauer, Eileen, Satyamurthy, Nagichettiar, Nguyen, Khoi, Toyokuni, Tatsushi, Phelps, Michael E, Herschman, Harvey R, Gambhir, Sanjiv S

“…We have synthesized and evaluated 8-[18F]fluoropenciclovir (FPCV) and compared it with 8-[18F]fluoroganciclovir (FGCV) for monitoring the expression of herpes…”
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Amyloid and tau imaging, neuronal losses and function in mild cognitive impairment by Barrio, J. R., Kepe, V., Satyamurthy, N., Huang, S. C., Small, G.

“…Objectives : Establish new approaches for early diagnosis of dementia, based on imaging amyloid and tau pathology, cell losses and neuronal function, in…”
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Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors by YAGHOUBI, S. S, WU, L, LIANG, Q, TOYOKUNI, T, BARRIO, J. R, NAMAVARI, M, SATYAMURTHY, N, PHELPS, M. E, HERSCHMAN, H. R, GAMBHIR, S. S

“…Biodistribution, magnitude and duration of a therapeutic transgene's expression may be assessed by linking it to the expression of a positron emission…”
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Quantitative imaging of gene induction in living animals by SUN, X, ANNALA, A. J, GAMBHIR, S. S, YAGHOUBI, S. S, BARRIO, J. R, NGUYEN, K. N, TOYOKUNI, T, SATYAMURTHY, N, NAMAVARI, M, PHELPS, M. E, HERSCHMAN, H. R

“…Methods to repeatedly, non-invasively, and quantitatively image gene expression in living animals are rapidly emerging and should fundamentally change studies…”
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Monitoring adenoviral DNA delivery, using a mutant herpes simplex virus type 1 thymidine kinase gene as a PET reporter gene by LIANG, Q, NGUYEN, K, SATYAMURTHY, N, BARRIO, J. R, PHELPS, M. E, GAMBHIR, S. S, HERSCHMAN, H. R

“…Current gene therapy protocols often suffer from an inability to monitor the site, level and persistence of gene expression following somatic DNA delivery…”
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Amyloid and tau imaging, neuronal losses and function in mild cognitive impairment by Barrio, J.R., Kepe, V., Satyamurthy, N., Huang, S.C., Small, G.

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Evaluation of the Skeletal Kinetics of Fluorine-18-Fluoride Ion with PET by Hawkins, Randall A, Choi, Yong, Huang, Sung-Cheng, Hoh, Carl K, Dahlbom, Magnus, Schiepers, Christiaan, Satyamurthy, Nagichettiar, Barrio, Jorge R, Phelps, Michael E

“…To evaluate the feasibility of quantitatively assessing regional skeletal fluoride uptake in humans in focal and generalized bone disease, we investigated the…”
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Synthesis of 8-[ 18F]fluoroguanine derivatives: in vivo probes for imaging gene expression with positron emission tomography by Namavari, Mohammad, Barrio, Jorge R, Toyokuni, Tatsushi, Gambhir, Sanjiv S, Cherry, Simon R, Herschman, Harvey R, Phelps, Michael E, Satyamurthy, N

“…A new method for the preparation of 8-[ 18F]fluoroguanine derivatives based on a direct radiofluorination reaction has been developed. The radiofluorination of…”
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Regioselective radiofluorodestannylation with [18F]F2 and [18F]CH3COOF: a high yield synthesis of 6-[18F]Fluoro-L-dopa by Namavari, M, Bishop, A, Satyamurthy, N, Bida, G, Barrio, J R

“…A protected 6-trimethylstannyl dopa derivative 6 has been synthesized for the first time as a precursor for the preparation of 6-[18F]fluoro-L-dopa. The tin…”
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Novel observations with FDOPA-PET imaging after early nigrostriatal damage by Yee, R.E., Irwin, I., Milonas, C., Stout, D.B., Huang, S-C., Shoghi-Jadid, K., Satyamurthy, N., Delanney, L.E., Togasaki, D.M., Farahani, K.F., Delfani, K., Janson, A.M., Phelps, M.E., Langston, J.W., Barrio, J.R.

“…Striatal 6‐[18F]fluoro‐L‐DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in…”
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Kinetics and modeling of L-6-[18F]fluoro-dopa in human positron emission tomographic studies by Huang, S C, Yu, D C, Barrio, J R, Grafton, S, Melega, W P, Hoffman, J M, Satyamurthy, N, Mazziotta, J C, Phelps, M E

“…Kinetics of L-3,4-dihydroxy-6-[18F]fluorophenylalanine (FDOPA) in striatum and cerebellum were measured in 10 normal human subjects with positron emission…”
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Elemental Fluorine to 8-Fluoropurines in One Step by Barrio, Jorge R, Namavari, Mohammad, Phelps, Michael E, Satyamurthy, Nagichettiar

“…An efficient regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine is described. The…”
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Nigrostriatal Reduction of Aromatic L‐Amino Acid Decarboxylase Activity in MPTP‐Treated Squirrel Monkeys: In Vivo and In Vitro Investigations by Yee, R.E., Huang, S.‐C., Stout, D.B., Irwin, I., Shoghi‐Jadid, K., Togaski, D.M., DeLanney, L.E., Langston, J.W., Satyamurthy, N., Farahani, K.F., Phelps, M.E., Barrio, J.R.

“…Aromatic L‐amino acid decarboxylase (AAAD) activity was examined in vivo with positron emission tomography (PET) using 6‐[18F]fluoro‐L‐DOPA (FDOPA) in squirrel…”
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